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Review Article
Rodney P Jones View abstract
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ShareThe World Health Organisation (WHO) has recently highlighted the possibility of a curious Disease X with potential to cause an international public health emergency. This research update details the progress to-date at identifying potential outbreaks of Disease X. During these outbreaks’ medical admissions and deaths, but not surgical, increase for an approximate 12-month duration, before reverting to the baseline level. These outbreaks appear to initiate most commonly in the interval from the end of winter to the end of spring. A range of medical admissions increase which seemingly have a common immune function linkage, possibly related to certain types of inflammatory response. Research on alternative immune steady states presents a possible basis for this on/off switching of population health. As t..... ReadMore -
Research Article
Shirin Akter, S.M. Azharul Islam, M. Obaidur Rahman, K.M. Mamun, M.J. Kabir, M. Safiur Rahman, B.A. Begum, M. Joynal Abedin, S.I. Tushar4 and Y.N. Jolly* View abstract
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SharePresent study deals with the investigation of the magnitude of toxic elements in commonly consumed vegetables grown in the vicinity of a Fertilizer Factory and evaluate the degree of health risk burden due to dietary intake of those vegetables as well. The vegetable samples showed greatest probabilities of toxic elements (Cr, Mn, Fe, Ni, Cu, Zn, As and Pb) contamination depending on their species and locations. To find out the possible source of contaminants, soil samples from where the vegetable samples were collected were also analysed. In most cases concentration of all the elements (Cr, Mn, Fe, Ni, Cu, Zn, As and Pb) in soil samples are equal to or near the suggestive world average value. To find out the solubilisation of these contaminants, soil-plant Transfer Factor (TF) was also calculated and the value obtained are below 1 i..... ReadMore
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Opinion
E. Ahmed View abstract
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ShareHybrid cancer cells have been recently discovered. They have greater ability to form metastasis. Here a simple mathematical model is given for this phenomenon. Some comments about the possibility of their reaching brain are given...... ReadMore
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Short Communication
Afonin SM* View abstract
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ShareThe structural scheme and the transfer functions, the characteristics of the electro elastic actuator for micro and nano surgical repairs are obtained. The transfer functions of the electro elastic actuator are described the characteristics of the actuator with regard to its physical parameters and external load...... ReadMore
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Research Article
Snehasis Jana View abstract
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ShareThe study was performed to assess the impact of Biofield Treated test item (DMEM medium) on Human Endothelial Hybrid Cell Line (EA. hy926) for the expression of cyclic guanosine monophosphate (cGMP). The test item was divided into three parts. The first part was received one-time Consciousness Energy Treatment by a renowned Biofield Energy Healer, Mahendra Kumar Trivedi and labeled as BT-I, while second part received two-times Biofield Treatment and is denoted as BT-II. The third part did not receive any types of treatment and denoted as untreated DMEM. The level of intracellular cGMP in the BT-I and BT-II groups showed a significantly (p≤0.001) increased by 296.06% and 339.37%, respectively in Ea. hy926 cells compared to the untreated DMEM group. These results suggest that BT-II group showed a significant improved the level of cG..... ReadMore
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Research Article
Moniruzzaman* View abstract
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ShareIn this study, Metronidazole (Met) and it’s modified derivatives are optimized by employing density functional theory with B3LYP/6-31g (d,p) level theory to explore their structural and thermodynamical properties. Molecular electrostatic potential (MEP) calculation has performed to calculate their possible electrophilic and nucleophilic attack. ADMET prediction was performed to search the absorption, metabolism and toxic level. Finally, this study can be helpful to design a potent candidate...... ReadMore
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Research Article
Nida Tabassum Khan View abstract
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ShareIntense and tenacious feeling of despondency or loss of interest in things that once were enjoyable such condition is termed as Depression which is characterized as a mental illness and contributes a considerable fraction of the inclusive burden of diseases. Determinants of depression among married women includes gender discernment, over burden of work, domestic violence, psychological distress, sexual abuse, women’s poor mental and physical health etc. Identification of potential determinants of depression will possibly aid in devising preemptive strategies in order to reduce its pervasiveness among married women...... ReadMore
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Mini Review
Nida Tabassum Khan*, Namra jameel, Maham Jamil Khan View abstract
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ShareBiofertilizers are constituents of microbial cells that colonizes rhizosphere of the plants to improve nutrients uptake by increasing the rate of mineralization of insoluble nutrients in the soil through numerous natural process such as nitrogen fixation, phosphorous fixation etc...... ReadMore
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Review Article
Ibtisam Kamal* View abstract
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ShareNanomaterials are materials engineered with extremely small particle size having at least one dimension in the range of 1 to 100 nanometers (nm). It is well established that when materials are produced in nano scale, they demonstrate unique electronic, magnetic, catalytical as well as optical properties that candidate them for wide range of applications in engineering, medical and environmental fields. An extensive variety of nanomaterials has been manufactured, and already been used in many products and much more extensive utilization is expected in the future. The contribution of nanotechnology to research and development in industrial sectors results in increasing the efficiency and productivity of the industrial processes and brings huge promise in producing new nanomaterials and products, with tailored characteristics that ..... ReadMore
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Review ArticleDiabetes, Dipeptidyl Peptidase iv and Wound Healing: from Basic Science to Therapeutic Possibilities
Lara Baticic Pucar View abstract
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ShareDiabetes mellitus, a chronic metabolic disease characterized by different pathological outcomes as a consequence of unsettled hyperglycemia, often accompanied with various complications such as chronic ulcers, represents a major socio-economic health problem. Dipeptidyl peptidase IV or CD26 molecule (DPP IV/CD26), is an omnipresent transmembrane protein with significant involvements in different physiological and pathological processes. It has been recognized as a therapeutic option in the treatment of hyperglycemia, especially in patients suffering from type 2 diabetes, given its capability to regulate the biological activity of incretins, which are major regulators of glucose homeostasis. Furthermore, DPP IV/CD26 has been indicated to be involved in the regulation of inflammatory processes as well as cell proliferation and angiogenesi..... ReadMore
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Review Article
Pang Xiao Feng* View abstract
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ShareWe here researched the features of transport of nerve impulse along the nerve fiber using modern theory of molecular biology, in which we first elucidate the properties of structure of the nerve cell and the features of distribution of the charges for the sodium ions and potassium ions in the inner and exterior of the never cell membranes. In practice, their distributions are not uniformity, where the distribution of sodium ions and potassium ions between the inner and exterior of cell-membranes are not same, they are just inverse. Just so, an action electro-potential occurs in the cell-membranes. However, the action electro-potential is only a static impulse, it cannot propagate along the nerve organizations. If the nerve organizations are acted by the bio-energy, which could lead to the periodic variation of these sodium ions and potass..... ReadMore
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Mini Review
Jui-Teng Lin* View abstract
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ShareWe will review the kinetics, applications and efficacy of light-activated crosslink. The crosslink efficacy is influenced by multiple factors including: the applied light intensity, exposure period and dose, the initial concentration profiles of photosensitizers (PS) and oxygen, the quantum yield of the PS triplet state, the kinetic rate constants of PS (in type-I) and oxygen concentration (in type- II). Lower light intensity (I 0 ) and higher PS concentration (C 0 ) provides higher efficacy, but also suffers more toxicity to the cells. Higher light intensity (I 0 ) may accelerate the crosslink but has lower efficacy (for the same dose). Therefore, optimal ratio of C 0 / I 0 is required for accelerated and safe crosslink. Safety issue also limits the maximum dose can be applied to the collagen, besides the limitation ..... ReadMore
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Research Article
Vladimir Zaichick* and FRS Sofia Zaichick View abstract
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ShareA prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of chemical element contents in thyroid may play important role in goitro- and carcinogenesis of gland. The variation with age of the mass fraction of twenty chemical elements (Ag, Br, Ca, Cl, Co, Cr, Cu, Fe, Hg, I, K, Mg, Mn, Na, Rb, Sb, Sc, Se, Sr, and Zn) in intact (normal) thyroid of 72 males (mean age 37.8 years, range 2-80 years) was investigated by energy dispersive X-ray fluorescent analysis and instrumental neutron activation analysis with high resolution spectrometry of short- and long-lived radionuclides. This work revealed that there is a statistically significant increase in Ca, I, and Se mass fraction, as well as a decrease in K and Mn mass fraction in the normal thyroid of male during a lifespan...... ReadMore
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Research Article
Sudha Melluri and Abbaraju Krishna Sailaja* View abstract
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ShareZingiberofficinale belonging to family Zingiberaceae is an ancient Indian medicine used in several disorders. The main object behind to isolate starch from the ginger rhizome. Ginger is the rhizome of the plant Zingiberofficinale, Starch is one of the most abundant organic chemicals on earth and it is synthesized in the amyloplasts of seeds, grain, roots and tubers of many plants where it serves as the chemical storage form of energy from the sun. Many drugs commonly used today are herbal origin. Herbal medicine is the oldest form of healthcareknown to mankind. Herbs have been used by all cultures throughout history. Herbal medicine is also in great demand in developed world for primary healthcare because of their efficacy, safety and lesser side effects. The aim of present study is to isolate and Phytochem..... ReadMore
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Mini Review
Ibtisam Kamal* View abstract
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ShareAll over the world, women are facing different challenges, among them the increase in violance with increasing in life developments and the accelerating in social change. In spite of numerous numbers of studies imply the impact of socialization and tradition on women subordination, and the advocated ideas of democracy and secularism support women movement and needs as well, women across the world aspirations are still far from achieving the optimum situation. The curent paper reviews the role of gender inequality and the associated aspects, and highlighting the principles of the physical differences between women and men that may explain why men play as the principal factor in violence against women...... ReadMore
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Mini Review
Nouman Rasool* View abstract
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ShareProlyl oligopeptidase is an important enzyme known to be involved in many human diseases including Alzheimer disease, Parkinson disease and dementia. Microbial world is rich with many diversified enzymes which can be studied as analogous to eukaryotic counter parts. Genome survey of Pyrobaculum calidifontis revealed that three prolyl oligopeptidase with ORFs P_cal 0773; P_cal 1307 and P_cal 1997 are present in this microbe while none of these have been studied. In this study, molecular modeling and in silico characterization of the enzyme prolyl oligopeptidase (P_cal 0773) is performed. The tertiary structure of the enzyme has conserved residues Ser431, Asp513 and His 545 at active site. The structure was observed to have two domains which were α/β hydrolase fold and β-propeller. Where β-propeller domain, most specific fea..... ReadMore
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Mini Review
Arun Kumar Srivastava View abstract
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ShareThe snail Lymnaea acuminata is the intermediate host of liver fluke Fasciola gigantica which causes endemic fasciolosis in cattle as well as human population of Eastern Utter Pradesh. Snail control with plant mollucicides has been one of the effective methods used for rapid and effective control of Fasciolosis. Toxicity of active molluscicidal component present in them are more potent than there synthetic counterpart. The metabolic activity of invertebrates is influenced to a large extent by change in both biotic and abiotic factors, which mainly depends on the season. These abiotic factors and bait containing plant molluscicides can significantly alter the biochemical parameters and ultimately the reproduction rate and developmental process of snail Lymnaea acuminata seasonally...... ReadMore
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Review Article
Bich Ha Nguyen* View abstract
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ShareThe present article is a concise review on the application – oriented basic research on nanomedicine in Vietnam during the 5-year period 2012-2016. The content of review includes following topics: biomedical utilization of targeting folate-decorated paclitaxel-loaded PLA-TPGS nanomaterial, dendrimer-based anticancer drug, special drug delivery nanosystems, various utilization of nanocurcumin in nanomedicine, biosensor and biosensing methods, and antibacterial activity of several types of nanoparticles...... ReadMore
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Mini Review
Ajay K Ray* View abstract
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ShareBiopharmaceuticals are mostly protein-derived medical drugs play vital roles in the human body catalyzing sequence of biochemical reactions. These biologics, which include therapeutic proteins, monoclonal antibodies (MAbs), vaccines, hormones, and fusion proteins, are used in the treatment, diagnosis and prevention of specific diseases such as cancer, multiple sclerosis, rheumatoid arthritis, diabetes, and a variety of cardiovascular diseases [1-3]. They are large molecular weight compounds with complex 3D structures mimicking molecules found in human bodies. Their production by living cells makes them different from classical small molecular weight chemical drugs (e.g., antibiotics) and in general, protein drug production by living cells is generally ..... ReadMore
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Mini Review
Jack Kushner* View abstract
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ShareIn addition to the challenges of treating patients with spinal cord injuries, it can be most distressing and daunting managing the complications with these injuries. This article discusses some of these problems and how to avoid and treat many of them...... ReadMore
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Perspective
Ross Bogey* View abstract
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ShareAdults with neurological injury (e.g. stroke, spinal cord injury) report that recovery of walking is a primary goal [1]. While many recover at least the ability to perform short distance, household level walking, community level ambulation at even moderate walking speeds is beyond the ability of most of these individual [2]. While the brain is involved in several aspects of gait initiation, termination, responding to environmental perturbations much of walking is controlled and monitored in the spinal cord, specifically in the central pattern generators (CPG). This was demonstrated nearly one half century ago, where early studies of spinal cord injured quadrupeds demonstrated reciprocal locomotion patterns in the absence of direct signals from the brain...... ReadMore
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Research Article
Hadi Mohammadi View abstract
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ShareAtherosclerotic plaques are highly heterogeneous, nonlinear materials with uncharacteristic structural behaviors. It is well known that mechanics of atherosclerotic plaques significantly depend on plaque geometry, location, composition, and loading conditions. Computational studies have shown great potential to characterize this mechanical behavior. Different types of plaque morphologies and mechanical properties have been used in a computational platform to estimate the stability of rupture-prone plaques and detect their locations. In this study, we hypothesize that heart rate (HR) is also one of the major factors that should be taken into account while mechanics of plaques is studied. We propose a tunable viscoelastic constitutive material model for the fibrous cap tissue in order to calculate ..... ReadMore
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Research Article
Sajeesh Kumar View abstract
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ShareElectronic transmission of data is on the rise, due to the Affordable Care Act and provisions to make healthcare information more accessible, complete, and transparent. The Personal Health Record (PHR) application is a tool used to provide assistance to the goal of patient-centered and patient-centric care. Its purpose is to encourage consumers to become more participatory and informed in their healthcare treatment and healthcare needs. Since its inception, it has been questionable as to whether consumers and providers are seeing any improvements in the services provided or the care rendered. Since, the development and implementation of PHR applications, there has been some resistance from consumers for concerns of privacy and security of their information. This paper will discuss the uses of the PHR among consumers and providers and whet..... ReadMore
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