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Short CommunicationView abstract PDF Full textThe infectious Covid disease is caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Many countries have been performing genomic surveillance on Covid, and at least 96 countries have their sequencing results available [1]. Due to continuous mutations, there are significant differences among the sequencing results from different research groups from these countries. It has consumed more than 8 billion research funds in order to find a specific treatment...... ReadMore
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Research ArticleView abstract PDF Full textInsulin icodec is a long-acting basal insulin analog under development that can be administered once weekly. The main purpose of this article is to provide an appraisal on insulin icodec based on available data published in a series of phase 3 clinical trials collectively called the ONWARDS Program...... ReadMore
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Short CommunicationView abstract PDF Full textAtrophy of uterine cervix is comprised of enhanced quantification of basal and parabasal squamous epithelial cells and may simulate squamous intraepithelial lesion (SIL) on morphological grounds. Lesion may be discerned upon clinical determination of atypical squamous epithelial cells of undetermined significance ASCUS...... ReadMore
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OpinionView abstract PDF Full textIn experiments, we studied the states of testicular morphology in rats at different times (3-10-40-60-90 days) after a single dose of 0.5 Gy (power 0.92 Gy/min, 137Cs source) external total-body γirradiation. Histological preparations were prepared, stained with hematoxylin-eosin and the number of transversely cut convoluted seminal tubules was calculated..... ReadMore
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Review ArticleView abstract PDF Full textThe drug delivery industry is currently experiencing intense competition and quick evolution due to an ever-growing demand. One such novel and distinctive drug delivery method that is quickly gaining popularity in the realm of rapid dissolving technology is the fast-dissolving tablet (FDT)..... ReadMore
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OpinionView abstract PDF Full textThe scientific and medical understanding of the COVID-19 disease is progressing speedily and a number of investigational new drugs (IND) or repurposed drugs underwent clinical trial for efficacy and safety analysis [1]...... ReadMore
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Mini ReviewView abstract PDF Full textThe directed modification of biologically active substances is one of the main approaches to molecular design and is an urgent problem in medicinal chemistry. The presence of free amino groups in the chitosan molecule makes it possible to synthesize various classes of chitosans, which exhibit increased activity compared to the original chitosan. The traditional methods for modifying chitosans based on covalent bonding formation with chemical groups, which is usually difficult to perform compared to quaternization. Since both chitosan and pyrazoles exhibit a broad spectrum of biological activities, the aim of this work is to synthesize 4-nitro-3(5)- pyrazole carboxylic acids and to study their anti-burn activity based on prepared quaternary ammonium salts...... ReadMore
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Review ArticleView abstract PDF Full textNew series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzyl isothiocyanate and aminopyrazoles. Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial species..... ReadMore