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Research Article
Nasser Mikhail* View abstract
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Insulin icodec is a long-acting basal insulin analog under development that can be administered once weekly. The main purpose of this article is to provide an appraisal on insulin icodec based on available data published in a series of phase 3 clinical trials collectively called the ONWARDS Program...... ReadMore -
Short Communication
Anubha Bajaj* View abstract
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Atrophy of uterine cervix is comprised of enhanced quantification of basal and parabasal squamous epithelial cells and may simulate squamous intraepithelial lesion (SIL) on morphological grounds. Lesion may be discerned upon clinical determination of atypical squamous epithelial cells of undetermined significance ASCUS...... ReadMore
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Opinion
Makhanad Ali Al Meselmani* View abstract
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In experiments, we studied the states of testicular morphology in rats at different times (3-10-40-60-90 days) after a single dose of 0.5 Gy (power 0.92 Gy/min, 137Cs source) external total-body γirradiation. Histological preparations were prepared, stained with hematoxylin-eosin and the number of transversely cut convoluted seminal tubules was calculated..... ReadMore
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Review Article
Raghavendra Kumar Gunda*, JN Suresh Kumar, B Yamini, B Naveena, L Sravani, SK Mansur Ali and Ch Priyanaka View abstract
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The drug delivery industry is currently experiencing intense competition and quick evolution due to an ever-growing demand. One such novel and distinctive drug delivery method that is quickly gaining popularity in the realm of rapid dissolving technology is the fast-dissolving tablet (FDT)..... ReadMore
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Opinion
Asis Bala* and Adrija Sil View abstract
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The scientific and medical understanding of the COVID-19 disease is progressing speedily and a number of investigational new drugs (IND) or repurposed drugs underwent clinical trial for efficacy and safety analysis [1]...... ReadMore
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Mini Review
Hasmik Nver Khachatryan* , LA Bichakhchyan, HV Gasparyan and HS Attarya View abstract
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The directed modification of biologically active substances is one of the main approaches to molecular design and is an urgent problem in medicinal chemistry. The presence of free amino groups in the chitosan molecule makes it possible to synthesize various classes of chitosans, which exhibit increased activity compared to the original chitosan. The traditional methods for modifying chitosans based on covalent bonding formation with chemical groups, which is usually difficult to perform compared to quaternization. Since both chitosan and pyrazoles exhibit a broad spectrum of biological activities, the aim of this work is to synthesize 4-nitro-3(5)- pyrazole carboxylic acids and to study their anti-burn activity based on prepared quaternary ammonium salts...... ReadMore
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Review Article
Abdel Haleem M Hussein*, Abu-Bakr AM El-Adasy, Ahmed AM El-Shareef, and Ahmed A Khames View abstract
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New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzyl isothiocyanate and aminopyrazoles. Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial species..... ReadMore
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Research Article
Raghavendra Kumar Gunda*, Prasada Rao Manchineni and Rajini Sudireddy View abstract
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The main objective of the current work is to study the effect of super disintegrants in combination for the drug release of Tolvaptan. HCl by developing Fast Disintegrating Tablets (FDT). Tolvaptan. HCl, a newer aquaretic sorvaptan. It mainly used for the effective management of Hyponatremia associated with Syndrome of Inappropriate Anti Diuretic Hormone (SIDAH). Mouth dissolving formulations of Tolvaptan. HCl were prepared using different quantities of Kollidon & Primellose employed as Superdisintegrants by Direct Compression technique. Amount of super disintegrants need to get desired drug release was labeled as factors. Disintegration time, wetting time, times taken for dissolution were labeled as responses. Nine trials were formulated as per 32 factorial design and characterized for quality control parameters. Data obtained from..... ReadMore
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Drug Designing & Intellectual Properties International Journal
Drug Designing & Intellectual Properties International Journal (DDIPIJ) is an international peer reviewed open access journal presenting original research and contributions and scientific advances in the field of drug design and development. Drug Designing & Intellectual Properties International Journal welcomes research articles, review articles, letter to the editors, editorials, case reports and innovations relating to all aspects of drug design and development and related sciences. Intellectual property (IP) pertains to any original creation of the human intellect such as artistic, literary, scientific creation. Several types properties of intellectual property protection like patent, copy right, trademark, etc. Patent is recognition for invention, which satisfies the criteria of global innovation, non obviousness.
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