Mirta D’ Ambra*

DOI : 10.32474/DDIPIJ.2020.03.000162

View abstract PDF Full text

Share

There are medicines registered as such-and subject to the legislation of pharmaceutical specialties-and products that, without being registered as medicines, are sold and actively promoted, giving them medicinal virtues.Among the medications it is necessary to distinguish those of prescription or prescription sale, of those without prescription or over the counter (over the counter or OTC counter medications in Anglo-Saxon terminology). On these there is the wrong an installed assumption among the general public, which considers “over-the-counter” medicines safe. All medications without exception, used in excessive doses or for too long periods, in situations where they would not be indicated, can cause side effects, collateral, undesirable or adverse effects, generate in.....ReadMore

Jagessar RC*

DOI : 10.32474/DDIPIJ.2019.03.000161

View abstract PDF Full text

Share

Insecticides are a group of compounds with heterogenous toxicity, whose intended purpose is to kills insects. Synthetic insecticides are known for their very harmful environmental and health impacts. This therefore generates a need for a safer solution. Botanicals are a special group of insecticides with a natural origin, obtained primarily from plant parts. There is a continued interest to screen plants for their insecticidal activities in light of the great destruction done to crops that affect the livelihood of the populace worldwide, especially in countries, whose GDP depends primarily on agriculture. Guyana, a country on the mainland of South America is no exception. Agricultural produce is now threaten by emerging new species of insect pests, such as in the rice Insecticides are a group of compounds with heterogenous toxicity, who.....ReadMore

Oludare Temitope Osuntokun, Thonda Oluwakemi Abike and Adeleye Bukola Mary

DOI : 10.32474/DDIPIJ.2019.03.000159

View abstract PDF Full text

Share

Water quality and treatment is becoming of great concern, especially in developing country like Nigeria where water quality is poor and not properly treated. It is in this light that this research was carried out to confirm the effectiveness of powdered extracted from matured dried Moringaoleifera seed which is commonly available in most rural communities in Nigeria and Tamarindus indica seed which is mostly available in the Northern part of Nigeria. The aim of this study is to determine the physiochemical properties, microbial load, and effectiveness of the natural coagulant (Moringaoleifera and Tamarindus indica seed extracts) on the collected water samples. Seed extracts were prepared and pour plate techniques was carried out to determine the microbial load before and after introduction of the seed extracts, colonial and biochemical ch.....ReadMore

Oludare Temitope Osuntokun, Thonda Oluwakemi Abike and Adeleye Bukola Mary

DOI : 10.32474/DDIPIJ.2019.03.000159

View abstract PDF Full text

Share

Abstract: Water quality and treatment is becoming of great concern, especially in developing country like Nigeria where water quality is poor and not properly treated. It is in this light that this research was carried out to confirm the effectiveness of powdered extracted from matured dried Moringa oleifera seed which is commonly available in most rural communities in Nigeria and Tamarindus indica seed which is mostly available in the Northern part of Nigeria. The aim of this study is to determine the physiochemical properties, microbial load, and effectiveness of the natural coagulant (Moringa oleifera and Tamarindus indica seed extracts) on the collected water samples. Seed extracts were prepared and pour plate techniques was carried out to determine the microbial load before and after introduction of the seed extracts, colonial and bi.....ReadMore

Abdul Kader Mohiuddin*

DOI : 10.32474/DDIPIJ.2019.03.000156

View abstract PDF Full text

Share

According to World Bank publication Disease Control Priorities: Improving Health and Reducing Poverty (3rd edition, 2017), nearly 20% total health expenditure globally came from out-of-pocket payments in 2014. The same was nearly 40% total health expenditure for low-income countries, 56% for lower-middle-income countries, and 30% for upper-middle-income countries (WHO, 2016). One third of the world’s population lacks timely access to quality-assured medicines while estimates indicate that at least 10% of medicine in low- and middle-income countries (LMICs) are substandard or falsified, costing approximately US$ 31 billion annually (Global Health, 2018). Surprisingly, 80% of global cardiovascular deaths occur in LMICs which is (partly) due to the lack of access to healthcare including skilled human resources, equipped facilities and medi.....ReadMore

Yuri S Pestovsky* and Agustino Martínez-Antonio

DOI : 10.32474/DDIPIJ.2019.03.000155

View abstract PDF Full text

Share

Alginate is a natural polysaccharide that is widely used as a component of pharmaceuticals and in food industry. Alginate particles can be used for encapsulation of substances with the necessity of prolonged release. They can also provide appropriate microenvironment for cells. Here the methods of the synthesis of alginate beads, micro- and nanoparticles are reviewed with special attention to the calcium alginate ones. The results from publications that did not deal with alginate particles but, to our opinion, could be applied in this field are also included in order to give an outline for possible future research. The suggested applications of the particles are mentioned as well. The two main methods for the synthesis of calcium alginate particles are internal and external gelation, but the external gelation techniques.....ReadMore

Teodora E Harsa*, Alexandra M Harsa and Mircea V Diudea

DOI : 10.32474/DDIPIJ.2019.03.000154

View abstract PDF Full text

Share

Serotonin, 5-hydroxytryptamine, represents a class of monoamine neurontransmitters, all of which having a chemical template comprised of a basic amino group separated from an aromatic nucleus by a two-carbon aliphatic chain. In this paper we present a docking study on serotonin targeting the proteins 3ADX and 2YX8, respectively, performed by AutoDock Vina. A set of thirty-five serotonins, downloaded from PubChem, was modeled, within the hypermolecule strategy; the predicted activity was LD50 and prediction was done on similarity clusters with the leaders chosen as the best docked ligands on the Peroxisome proliferator-activated receptor gamma. It was concluded that LD50 of the studied serotonins is not directly influenced by their binding energies to the target proteins......ReadMore

Mohamed A Gbaj, Inass A Sadawe, Nisreen H Meiqal, Salah M Bensaber, Massaud Salem Maamar, Anton Hermann and Abdul M Gbaj*

DOI : 10.32474/DDIPIJ.2019.03.000153

View abstract PDF Full text

Share

Venom of Cerastes cerastes has been extracted and its toxicity was investigated in the presence of aqueous and methanolic extracts of Citrus reticulata (Rutaceae) fruit peels. The decline in the mean survival time of the male albino swiss mice were used to deduce the venom property in the presence and absence of aqueous and methanolic extracts of Citrus reticulata (Rutaceae) fruit peels. The aqueous and methanolic extracts of Citrus reticulata (Rutaceae) fruit Peels significantly decrease the mean survival time compared to the venom alone. From these results it was evident that the toxicity of Cerastes cerastes venomis increased significantly in the presence of Citrus reticulata in a dose dependent manner.....ReadMore

Jagessar RC*

DOI : 10.32474/DDIPIJ.2019.03.000152

View abstract PDF Full text

Share

Diabetes mellitus is a chronic health problem with long term consequences that are potentially preventable. It is a heterogeneous group of disease, characterized by high blood glucose levels resulting from impaired insulin secretion, impaired insulin action, or both. There are several synthetic antidiabetic drugs. These include Insulin Secretagogues (Sulfonylureas), biguanides, Thiazolidinediones, α- Glucosidase, Glucagon. Although, antidiabetic agents such as insulin, biguanides, thiazolidinediones and α glucosidase inhibitors are available in Guyana to treat diabetes, a safe and effective treatment paradigm is yet to be achieved. This is due to that fact that these drugs fail to significantly reduce the course of diabetic complications and have limited use because of their undesirable patho.....ReadMore

Muhammad Imran Qadir and Hira Baig*

DOI : 10.32474/DDIPIJ.2019.03.000151

View abstract PDF Full text

Share

Dengue fever is a mosquito born disease. Biting of female mosquito transfer virus in to host through its tentacles and then it multiply, first when host defense mechanism strong it fights with phages after time they become resistant multiply and cause infection that cause dengue fever. Biology students gave their contribution in evaluation of understanding and their views relate to dengue fever. In Pakistan, upper Punjab suffered catastrophe of dengue fever. It was concluded that most subjects claimed mosquito infection was viral, also people claimed it never treated with surgery. Some people understood it can be treated by specific type of medicine, it also not metabolic disease......ReadMore

Manoj Ramesh Kumbhare*, Ajaykumar Rikhabchand Surana, Apurva Uttamrao Abhale, Ankita Ankush Bhoir and Shivam Puranmalgi Agrawal

DOI : 10.32474/DDIPIJ.2019.02.000150

View abstract PDF Full text

Share

Antibiotics are immense weapon that fight microbes. For decades, several varieties of antibiotics have not only been used for clinical purposes but practiced across other industries like agriculture and animal husbandry. The regular practice in antibacterial drug development has been to rapidly make an effort to find ever-more stable and broad-spectrum alternative for a particular antibiotic, once a drug resistance for that antibiotic is detected. We are now facing bacterial resistance toward our clinically relevant antibiotics of such a magnitude that the conversation for antimicrobial drug development ought to include effective new antibiotics with alternative mechanisms of action. Microbial resistance to antibiotics is a world-wide problem in human and veterinary medicine. It is generally accepted th.....ReadMore

Alice Branton, Mahendra Kumar Trivedi, Dahryn Trivedi, Gopal Nayak and Snehasis Jana*

DOI : 10.32474/DDIPIJ.2019.02.000149

View abstract PDF Full text

Share

Ascorbic acid is a water-soluble vitamin that mainly acts as an antioxidant and helps in controlling and maintaining various body functions. The study was designed to analyze the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of ascorbic acid by using sophisticated analytical techniques. For the study, the test sample ascorbic acid was divided into the control and treated sample. To the control sample, no Biofield Energy Treatment was provided. However, the treated sample received the Biofield Energy Treatment remotely by the renowned Biofield Energy Healer, Alice Branton, USA. The PXRD peak intensities and crystallite sizes of the treated sample significantly altered ranging from -78.43% to 1168.06% and -62.38% to 126.83%, respectively; along with 24.99% decrease in the.....ReadMore

Gopal Dixit*

DOI : 10.32474/DDIPIJ.2019.02.000148

View abstract PDF Full text

Share

Ethnomedicine is an area of research that deals with medicines derived from plants, animals and minerals etc. and used in the treatment of different human and veterinary ailments. Ethnomedicines includes indigenous beliefs, concepts, knowledge and practices among the ethnic groups, folk people and rural people for preventing, minimizing or curing various diseases. For this purpose, human groups around the world utilized the biological and cultural resources in their own way to develop resistance to combat different diseases, illness and health hazards arising from different pathogens and agents......ReadMore

Md Nur Kabidul Azam and Md Nasir Ahmed*

DOI : 10.32474/DDIPIJ.2019.02.000147

View abstract PDF Full text

Share

The Authors of this article has been working on ethnopharmacoloy and natural product science for the last one decade. They have been involved with several ethnic and traditional medication system development projects and also achieved recognitions in the medicinal plant sector of Bangladesh. Recently they have raised their interests on Nutrigenomics to introduce the “Personalized Nutrition” aiming to evolve the health maintenance in Bangladesh. The goal of this paper is to discuss opportunities and challenges for the next generation medicine in Bangladesh......ReadMore

Pervin Deveci*

DOI : 10.32474/DDIPIJ.2019.02.000146

View abstract PDF Full text

Share

Mesoporous silica nanoparticles (MSNs) have attracted extensive attention as efficient drug delivery carriers on account of its adjustable pore size, specific surface area, stability, and good biocompatibility. This review summarizes the recent advances on the application of gated MSNs for controlled drug delivery. These advanced technologies demonstrate current challenges and provide a bright future for precision of cancer treatment......ReadMore

Isak R Shaikh* and Alamgir A Shaikh

DOI : 10.32474/DDIPIJ.2018.02.000145

View abstract PDF Full text

Share

Historical records show that scientific advancements accounted for substantial changes in our life-style and wellbeing. The Industrial Revolution took place in the western countries in the 1700s when people first appreciated the terms ‘science’ and ‘technology’ and valued the applications of ‘technological innovations’ for their commercialization......ReadMore

François-Xavier Lacasse*

DOI : 10.32474/DDIPIJ.2018.02.000144

View abstract PDF Full text

Share

The author of this short communication has been working in and teaching drug development for the last 20 years. He has been involved in more than 100 drug development projects, including drug delivery, medical device, biologics, innovators and generic drugs. He has also been involved in all the steps that are needed to file properly to different governmental agencies investigational new drug applications (IND), clinical trial applications (CTA), abbreviated and new drug applications/submissions (ANDAS; NDA/S), 505b2, 510k and biologics legal applications (BLA)......ReadMore

Amit Gosar, Hussain Sayyed and Tabrez Shaikh*

DOI : 10.32474/DDIPIJ.2018.02.000143

View abstract PDF Full text

Share

The present work is based on a assess analysis of the literature in order to define the genotoxic impurities present in the drug substances and drug products. Starting from the definition of genotoxic impurities, sources of genotoxic impurities, their generation and classification based on their toxicity. The article also explains the various regulatory guidelines to control the genotoxic impurities in drug substances. Isolation, qualification of impurity and its identification along with quantification by the various analytical methods is also described in this review article......ReadMore

Benjamín Ruiz Loyola*

DOI : 10.32474/DDIPIJ.2018.02.000142

View abstract PDF Full text

Share

In all animal species competition between individuals is presented to obtain mainly food and reproduction; When there are not enough satisfiers, there are disputes that usually stop when there is a winner, without individuals dying. The defeated one retires, and the winner is satisfied with the victory and, eventually, with the dominion over the rest of the group, which implies that he will eat and mate before the others. So far, animals do not have too much trouble. But the human is a very special animal, because he has a memory......ReadMore

Amani Mohsen* and Rabih Chahine

DOI : 10.32474/DDIPIJ.2018.02.000141

View abstract PDF Full text

Share

Once Antiphospholipid syndrome (APS) is diagnosed, risk profile of the patient will impact its management whether there was a previous thrombotic event or not, association with other autoimmune disorders, presence of other obstetrical complications as well as being currently pregnant. The current recommended regimen for preventing obstetrical complications. The current recommended regimen for preventing obstetrical complications includes low molecular weight Heparin and low dose aspirin. This regimen decreases the risk of miscarriage by only 54%. Here, we will review the studies that evaluated adding Hydroxychloroquine (HCQ) to the treatment of APS and how effective it would be......ReadMore