Lupine Publishers Group

Makhanad Ali Al Meselmani*

DOI : 10.32474/DDIPIJ.2023.04.000181

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In experiments, we studied the states of testicular morphology in rats at different times (3-10-40-60-90 days) after a single dose of 0.5 Gy (power 0.92 Gy/min, 137Cs source) external total-body γirradiation. Histological preparations were prepared, stained with hematoxylin-eosin and the number of transversely cut convoluted seminal tubules was calculated..... ReadMore

Raghavendra Kumar Gunda*, JN Suresh Kumar, B Yamini, B Naveena, L Sravani, SK Mansur Ali and Ch Priyanaka

DOI : 10.32474/DDIPIJ.2022.04.000180

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The drug delivery industry is currently experiencing intense competition and quick evolution due to an ever-growing demand. One such novel and distinctive drug delivery method that is quickly gaining popularity in the realm of rapid dissolving technology is the fast-dissolving tablet (FDT)..... ReadMore

Asis Bala* and Adrija Sil

DOI : 10.32474/DDIPIJ.2021.04.000179

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The scientific and medical understanding of the COVID-19 disease is progressing speedily and a number of investigational new drugs (IND) or repurposed drugs underwent clinical trial for efficacy and safety analysis [1]...... ReadMore

Hasmik Nver Khachatryan* , LA Bichakhchyan, HV Gasparyan and HS Attarya

DOI : 10.32474/DDIPIJ.2021.04.000178

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The directed modification of biologically active substances is one of the main approaches to molecular design and is an urgent problem in medicinal chemistry. The presence of free amino groups in the chitosan molecule makes it possible to synthesize various classes of chitosans, which exhibit increased activity compared to the original chitosan. The traditional methods for modifying chitosans based on covalent bonding formation with chemical groups, which is usually difficult to perform compared to quaternization. Since both chitosan and pyrazoles exhibit a broad spectrum of biological activities, the aim of this work is to synthesize 4-nitro-3(5)- pyrazole carboxylic acids and to study their anti-burn activity based on prepared quaternary ammonium salts...... ReadMore

Abdel Haleem M Hussein*, Abu-Bakr AM El-Adasy, Ahmed AM El-Shareef, and Ahmed A Khames

DOI : 10.32474/DDIPIJ.2021.04.000177

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New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzyl isothiocyanate and aminopyrazoles. Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial species..... ReadMore

Raghavendra Kumar Gunda*, Prasada Rao Manchineni and Rajini Sudireddy

DOI : 10.32474/DDIPIJ.2021.04.000176

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The main objective of the current work is to study the effect of super disintegrants in combination for the drug release of Tolvaptan. HCl by developing Fast Disintegrating Tablets (FDT). Tolvaptan. HCl, a newer aquaretic sorvaptan. It mainly used for the effective management of Hyponatremia associated with Syndrome of Inappropriate Anti Diuretic Hormone (SIDAH). Mouth dissolving formulations of Tolvaptan. HCl were prepared using different quantities of Kollidon & Primellose employed as Superdisintegrants by Direct Compression technique. Amount of super disintegrants need to get desired drug release was labeled as factors. Disintegration time, wetting time, times taken for dissolution were labeled as responses. Nine trials were formulated as per 32 factorial design and characterized for quality control parameters. Data obtained from..... ReadMore

Snehasis Jana*, Mahendra Kumar Trivedi, Alice Branton and Dahryn Trivedi

DOI : 10.32474/DDIPIJ.2021.03.000175

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Flutamide is used to treat prostate cancer, which acts by blocking the action of exogenous testosterone binding through its androgen receptor. This study was designed and performed to investigate the impact of the Trivedi Effect® -Consciousness Energy Healing Treatment on the structural properties and the isotopic abundance ratio of flutamide using LC-MS and GC-MS spectroscopy. Flutamide sample was divided into control and treated parts. Only the treated flutamide received the Trivedi Effect® -Consciousness Energy Healing Treatment remotely by a famous Biofield Energy Healer, Mahendra Kumar Trivedi. The LC-MS spectra of both the samples at Retention time (Rt ) ~3.4 minutes exhibited the mass of the deprotonated molecular ion peak at m/z 275 [M-H]-. The peak area of the Biofield Energy Treated flutamide was significantly increas..... ReadMore

Sameer Shakur Shaikh*, Abdul Haque Bamer, Prasad Govindrao Jamkhande, Abdul samad and Quadri Mohammad Shoeb4

DOI : 10.32474/DDIPIJ.2021.03.000174

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More than half of the world’s population relies on traditional medicine and the main role of traditional medicine including the use of plant extract and their active constituents. Among them Adiantum capillus veneris Linn. A small size wooden herb plant of the family Adiantaceae commonly called Parsioshan, Hansraj, Maidenhair fern, and Ghodkhuri. The plant has leaves, stem, and root that have been reported for possessing antioxidant, anti-microbial, anti-fungal, anti-diabetic, antipyretic, wound healing action and it is contraindicated in pregnancy due to its anti-implantation effect. It is most common in the treatment of hair fall and skin disease. The screening of phytochemical analysis showed the presence of flavonoids, alkaloids, tannins, saponins, cardiac glycosides, terpenoids, steroids, and reducing sugars. The present revi..... ReadMore