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Short Communication
Thomas Schaible* View abstract
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The successful use of ECMO in neonatal respiratory failure has stimulated its application in children and adults. In PARDS, ECMO may support systemic oxygen delivery while allowing lung-protective unloading of the injured lungs through a reduction in ventilatory intensity. However, implementation of ECMO requires appropriate institutional infrastructure as well as specialized personnel resources. In 2009, during the H1N1 influenza pandemic, approximately 2,000 pediatric ECMO cases were registered worldwide (see also the website of the Extracorporeal Life Support Organization, ELSO)...... ReadMore -
Research Article
Loai A Shakerdi, Darragh Nerney, E Crushell, A A Monavari, Mohamed Y Elsammak* View abstract
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Lysosomal storage disorders (LSDs) comprise a group of over 80 monogenic disorders. With a few exceptions, the majority are autosomal recessive. LSDs results from the accumulation of incompletely catabolized substrates due to specific enzyme deficiencies in certain metabolic pathways. The accumulated substances gradually impair the function of cell organelles, especially lysosomes. Due to the low incidence of LSDs, they may be overlooked, and patients may go through a diagnostic odyssey. A high index of clinical suspicion is needed to diagnose LSD. The measurement of enzyme activity as a diagnostic tool for LSD is considered the gold standard for diagnosis. Specific individual enzyme activity may be evaluated in leukocytes, plasma, Dried Blood Spot (DBS), or in fibroblasts cultured from a skin biopsy. More recently, two methods were intro..... ReadMore
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Review Article
Maria Alexandra Fleacă*, Alexandra Bratu, Mihaela Bizubac, Veronica Marcu, Cristina Filip, Carmen Herișeanu, Carmina Nedelcu, Cătălin Cîrstoveanu
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Opinion
Martha J Ignaszewski*, Reinhard Michael Krausz
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Research Article
Yanan Lu*, Guifen Fan*, Yongshun Su, Minghui Cao, Lin Cao, Dongni Xu* View abstract
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The incidence rate of recurrent laryngeal papilloma in children is 4.3 cases per 100000 people. It is a rare disease, but it is also the most critical benign tumor affecting children’s respiratory tract. Its clinical manifestations are hoarseness and upper respiratory tract obstruction of different degrees; Severe cases can directly endanger the life of the child due to upper respiratory obstruction, difficulty breathing, and subsequent suffocation. In recent years, high flow nasal cannula oxygen therapy (HFNO) has been shown to provide better oxygenation, ventilation, and maintain upper airway patency in adult patients with difficult airways. However, there is currently no reported experience in airway management of recurrent laryngeal papillomas in children with severe upper airway obstruction...... ReadMore
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Case Report
Charbell Miguel Haddad Kury*, Ana Carolina Pinto Mendes, Elisa Carvalhal de Souza, Thyara Boechat de Souza, Rafaella Silva Souza, Charles Bruno Soares, Cinthia Guimarães Leandro, and Bárbara Soares de Oliveira Souza View abstract
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Background: Therapeutic alternatives have been the subject of research for the treatment of persistent pulmonary hypertension of the newborn (PPHN). The use of tadalafil has shown to be a promising alternative to sildenafil. To analyze the evolution of eight newborns with PPHN admitted to an intensive care unit (ICU), which underwent therapeutic use of tadalafil in a daily dose of 1.5mg/kg/day every 24 hours. Methods: Review of medical records to assess several variables of interest performed before and after intervention with tadalafil. Results: The gestational age of neonates ranged from 31 weeks to 40 weeks and 5 days and the birth weight varied from 915 g to 4290 g...... ReadMore
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Short Communication
John R. Bach* View abstract
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“It is difficult to get a man to understand something when his salary depends upon his not understanding it (Upton Sinclair).” Before electricity became widely available after 1930, home mechanical ventilation was not possible. In the 1940s and 50s up to full continuous noninvasive negative pressure ventilatory support was provided by Iron Lungs and other body ventilators [1]. The Danes did not have these in 1952, so tracheotomies were first done for ventilatory support (CTMV). This spread to the U.S. However, in 1953 the mouthpiece CNVS was described by Dr. John Affeldt at Rancho Los Amigos in Los Angeles. In 1957 Dr. Augusta Alba removed 257 patients from body ventilators and placed them on up to continuous noninvasive positive pressure ventilatory support (CNVS) via simple mouthpieces which many used for CNVS for over 50 years and..... ReadMore
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Editorial
Nicola Sommer* View abstract
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Teachers are increasingly confronted with their students’ illnesses, because of better medical treatment successes, and/or due to an increase in civilization diseases or the effects of various stresses [1]. Currently, there are an average of four children and adolescents with a chronic disease in each class [2]...... ReadMore
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Progressing Aspects in Pediatrics and Neonatology
Progressing Aspects in Pediatrics and Neonatology (PAPN) is the official peer-reviewed publication of our Lupine Journal. Health care is the basic key for human beings. The fundamental aim of this journal is to help Pediatricians keep abreast of the latest development in Pediatric and Neonatal medicine and to improve the quality of life of new born babies, children and adolescents. The research published in PAPN is intended to comprise the needs of the field. In addition to the main focus on the studies of pediatric and neonatal diseases, we also publish on the hereditary, physiologic, psychological and common diseases of children. During this stage a particular process of evaluation, in Pediatrics and Neonatology endeavor to publish research at the highest value for pediatric healthcare professionals. PAPN journal cordially accepts all types of articles and we also assign DOI provided by Cross Ref and all the articles undergo peer review process by the experts which improves the quality of the article. The journal aims to publish novel works for authors which are original and unpublished. Research Articles, Review Articles, Case Reports, Opinions, Brief Communications, Letter to the Editor, Pediatric Images etc. are accepted for publication in PAPN Journal.
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