Background: Despite the long-standing concept of pulp tissue necrosis as the main etiologic factor for periapical lesions, there
has been new evidence that inflamed vital dental pulps can cause apical periodontitis (AP). Infected pulp could heal when the
etiological factor is eliminated. The present cases aimed to assess the outcome of vital pulp therapy (VPT) in permanent teeth with
vital pulps and signs of an AP.
Cases presentation: In the first case report a 15-year-old boy presented with a chief complaint of constant pain in #15
tooth, lasting for five days. After the clinical and radiographic examination, a diagnosis of pulp necrosis and symptomatic apical
periodontitis was conducted, and the root canal treatment (RCT) was initiated. The pulp chamber roof was removed. No intense
bleeding and coherent vital pulp tissue were observed; however, the pulp was in dark red color. VPT (pulpotomy) was decided to be
performed. In the second case a 16-year-old girl presented for an annual observation. After clinical and radiographic examination,
#45 tooth was diagnosed with caries. The excavation revealed caries lesion reaching the pulp. The exposed pulp was bright red
color, no intense bleeding overflowing from the exposure site was observed. VPT (pulpotomy) was a treatment of choice. In both
cases a layer of hydraulic calcium silicate cement was applied over the vital pulp tissue. In the second case a periapical radiograph
performed after the treatment revealed the large apical radiolucency. The teeth crowns were restored with the glass ionomer
cement initially or composite resin permanently, in the first and second case, respectively. At the follow-up visits, the patients
reported no symptoms. The dental periapical radiographs showed radiolucency considerably reduced in size and completely
healed after one year and two years.
Conclusion: Clinical and radiographic evidence of cases showed the successful use of mineral trioxide aggregate for pulpotomy
of mature teeth with vital pulps and signs of apical periodontitis.
Keywords: Vital pulp therapy; pulpotomy; apical periodontitis; mineral trioxide aggregate