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ISSN: 2637-6628

Online Journal of Neurology and Brain Disorders

Review Article(ISSN: 2637-6628)

Schizophrenia, Carbonyl Stress and Carnosine Volume 3 - Issue 4

Alan R Hipkiss*

  • Aston Research Centre for Healthy Ageing (ARCHA), Aston University, United Kingdom

Received: December 03, 2019;   Published: December 16, 2019

Corresponding author:Alan R Hipkiss, Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham, United Kingdom

DOI: 10.32474/OJNBD.2019.03.000168

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Abstract

Recent research suggests that schizophrenia is associated with the development of an advanced aging phenotype (carbonyl stress) and erythrocytes from schizophrenics also exhibit symptoms of cellular aging (increased levels of glycated proteins and ubiquitinated proteins), possibly due to excessive glycolysis-induced methylglyoxal (MG) generation. The endogenous dipeptide carnosine (beta-alanyl-L-histidine), which can delay cellular aging, suppress glycolysis and inhibit MG-induced protein glycation, also exerts some beneficial effects towards schizophrenia. Carnosine is present in human erythrocytes and the olfactory bulb (olfactory dysfunction is associated with schizophrenia). It is suggested that enhanced erythrocyte and olfactory carnosine levels may be more therapeutic towards schizophrenia, if carnosine was also administered intra-nasally to avoid serum carnosinase activity.

Keywords:Carnosine; glycation; methylglyoxal; erythrocyte; aging; nasal administration

Abstract| Introduction| References|

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