Association of IL-6 & C-Reactive Protein with Cognitive Decline in Dementia Volume 6 - Issue 1

Abhishek Khatri¹, Om Prakash1, Suman Kushwaha², Chandra Bhushan Tripathi³, Rachna Agarwal⁴*

• ¹Department of Psychiatry, Institute of Human Behaviour & Allied Sciences, India
• ²Department of Neurology, Institute of Human Behaviour & Allied Sciences, India
• ³Department of Biostatistics, Institute of Human Behaviour & Allied Sciences, India
• ⁴Department of Neurochemistry, Institute of Human Behaviour & Allied Sciences, India

Received:August 12, 2021   Published:September 3, 2021

Corresponding author:Rachna Agarwal, Associate Professor, Department of Neurochemistry, Institute of Human Behaviour & Allied Sciences, India

DOI: 10.32474/OJNBD.2021.06.000226

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Inflammatory markers Interleukin-6 (IL-6) and C-Reactive Protein (CRP) associated are with high rates of cognitive decline. Inverse relation between IL-6 levels and Hindi Mental Status Examination (HMSE) scores has been studied. IL-6 is a multifunctional cytokine is a key regulator of CRP. A cross sectional study was performed to examine the association between inflammatory markers (including IL-6, CRP and albumin) and cognition in subjects attending Neurobehavior clinic. 66 Dementia patients with average age of 69 ± 0.06 years were included in the study (44 Alzheimer’s Disease & 22 Vascular Dementia). AD cases were diagnosed according to ICD-10 and National Institute of Neurological Disorders and Stroke-Alzheimer Disease and Related Disorders Criteria (NINCDS-ADRDS) for probable AD and Vascular dementia cases were diagnosed with NINDS-AIREN criteria. All dementia cases were assessed using Hindi Mental Status Examination (HMSE) for cognitive function and Clinical Dementia Rating Scale (CDR) was applied for staging severity of dementia. Out of three inflammatory biomarkers (IL-6, CRP and albumin), IL-6 showed strong positive correlation with duration of illness in dementia cases, whereas CRP had weak positive correlation with duration of illness. Albumin showed no such relationship in dementia cases. On elimination of confounding variables, age and duration of illness, strength of relationship between HMSE and IL-6 was moderately negative but significant. Such relationship was nonexistent between HMSE and CRP as well as albumin.

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