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Vladimir L Martynov*

DOI : 10.32474/CTGH.2020.03.000152

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The goal is to assess the impact of biogenetic on the condition of patients with psoriasisMaterials and Methods: The study group included 415 patients aged 19 to 65 years (34% of men and 66% of women), in whom irrigoscopy revealed the injection of contrast into the ileum, i.e., the insolvency of the baugine flap (NBZ) was diagnosed, 74 of them suffered from psoriasis. For the detection of chronic intoxication were evaluated the data of clinical manifestations, indican urine, level of middle molecules, blood serum, lipid metabolism, microbial resistance, the hydrogen breath test. Results: NBZ is a chronic endointoxication, which regresses in collaboration with the clinical manifestations of psoriasis after biogenetic. Conclusion: Hypothesized that NBZ is one of the causes of psoriasis, and biogenetica – link in etiopath..... ReadMore

Lairani F, Ait Errami A* and Krati KH

DOI : 10.32474/CTGH.2020.02.000150

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Introduction: Gastrointestinal bleeding is a life-threatening condition, with mortality depending on the cause and severity. The objective of this study was to retrospectively evaluate the epidemiological, clinical and evolutive aspects of a series of patients diagnosed with upper gastrointestinal bleeding, admitted to the Intensive Care Unit of Arrazi hospital in Marrakech, Morroco. Material and methods: A retrospective, descriptive study was carried out, of patients diagnosed with upper gastrointestinal bleeding, admitted to the Intensive Care Unit of the Arrazi hospital in Marrakech, Morroco, between January 1st, 2018 – December 30th, 2018. Results: We observed that the three most frequent causes of upper gastrointestinal bleeding in our series were peptic ulcer disease, variceal hemorrhage and gastric cancer. The glob..... ReadMore

Ashamalla Michael

DOI : 10.32474/CTGH.2020.02.000149

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Our greater understanding of the Hepatitis C Virus (HCV) genome has led to the development of multiple direct- acting antivirals (DAAs) which are targeted medications at specific steps of the HCV life cycle. Antiviral therapy has become the cornerstone of treatment of chronic Hepatitis C (CHC) infection. With current antiviral therapies, CHC is easily treated and can be eliminated in almost all patients. The main targets of the DAAs are the HCV-encoded proteins that are vital to the replication of the virus. DAA therapies are efficacious up to 95%, tolerable, and safe with a mild side effect profile for the treatment of CHC. The clinical trials for HCV regimens did not include patients 80 years and older. Although widely used, there is limited data on their efficacy, tolerability, and sa..... ReadMore

Auzelivia Pastora Rego Medeiros Falcão, Carlos Henrique de Almeida Cipriano, Guilherme Castro de Queiroz, Nikolas do Vale Pedreira, Amália Cinhtia Meneses Rêgo, Irami Araújo-Filho*

DOI : 10.32474/CTGH.2020.02.000148

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Introduction: Technological advances in imaging studies have led to an increase in early diagnosis of benign and focal liver tumors such as simple cyst, hemangioma, focal nodular hyperplasia (UFH), adenoma. Objective: To evaluate the prevalence of benign liver lesions in the largest reference center for hepatology in the Rio Grande do Norte - University Hospital Onofre Lopes / Northeast Brazil. Methods: Cross-sectional descriptive study with a quantitative approach. The prevalence of focal benign hepatic lesions in patients from a referral center for hepatology in the Brazilian Northeast was evaluated. The sample was chosen by convenience, based on the analysis of patient records. Results: A total of 12,333 medical records were analyzed, and 640 selected with the initial ..... ReadMore

Abdul Kader Mohiuddin* and Nasirullah M

DOI : 10.32474/CTGH.2019.02.000146

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Irritable bowel syndrome (IBS) or irritable bowel disease (IBD), is also known as spastic colitis, mucus colitis, and nervous colon. It is a chronic, or long-term, condition, but symptoms tend to change over the years. It’s not uncommon for people with IBS to have episodes of both constipation and diarrhea. Symptoms such as bloating, and gas typically go away after a bowel movement. There is no cure for IBS. Treatment is aimed at symptom relief. Certain foods as well as stress and anxiety can be triggers for IBS symptoms for many people. Medications are available to ease the symptoms of IBS, but some patients feel better trying natural remedies instead of (or in addition to) conventional drugs...... ReadMore

George Khoudari

DOI : 0.32474/CTGH.2019.02.000145

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We report a patient with history of Crohn’s disease presenting with recurrent SBO; this is a common scenario for Crohn’s patients, as the disease process causes scarring and narrowing of the bowel, which can result in obstruction. Our patient had multiple emergency visits, courses of steroids, and was under consideration for biologic treatment aimed at apparent recurrent Crohn’s exacerbations while the true problem was a quarter causing symptomatic partial obstruction. Differential diagnosis of foreign body should be considered in cases of SBO, first or recurrent, where the cause is unclear. Extracting the quarter by ileoscopy resulted in an excellent patient outcome...... ReadMore

Bruce Dixon*, Evan Davidson and Stephen Pyles

DOI : 10.32474/CTGH.2019.02.000144

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We report a case of using a spinal cord stimulator for the treatment of severe chronic intractable abdominal pain associated with chronic pancreatitis and placement of intraabdominal stents. This patient also had concurrent severe chronic intractable cervicalgia with upper extremity radiculopathy secondary to failed back syndrome. The patient attempted and failed medical and interventional therapy for the treatment of her pains. Percutaneous 8 contact leads were placed midline at the level of C3-C6 and T5-T6 with excellent results. This case demonstrates that chronic pancreatitis can be successfully treated with spinal cord stimulation...... ReadMore

Vladimir Leonidovich Martynov* and Natalia Vladimirovna Kazarina

DOI : 10.32474/CTGH.2019.02.000142

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Objective: to determine the syndrome of excessive bacterial growth in the small intestine (SIBO) in patients with insufficiency of the bauhinia valve (NBZ) and after its surgical correction.Methods of Examination: patients of the studied groups were examined using direct and indirect methods of diagnosis of SIBO. Bacteriological examination of ileal aspirate and other surgical material was performed. All patients underwent a hydrogen respiratory test with a load of lactulose and performed a qualitative reaction of urine to indican..... ReadMore

Ahed J Alkhatib*

DOI : 10.32474/CTGH.2019.02.000141

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Irritable bowel syndrome (IBS) is a prevalent disease worldwide without curative and successful treatment. Its etiology is not fully understood. The main objective of the present study was to report the experience of treating patients with IBS using the aqueous extract of carob...... ReadMore

Alexandra Sack, Jayme Sack and Hari Tunuguntla*

DOI : 10.32474/CTGH.2019.02.000140

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Gastrointestinal disorders currently plague millions of Americans and place an immense physical, emotional, and financial burden on society. The conventional medicine paradigm produces modest effects but are often accompanied with adverse side effects as well as increased healthcare utilization. Thus, the demand for alternative therapies is increasing. In the event that conventional medicine offers no satisfactory solution, research provides consistent and compelling evidence for the efficacy of acupuncture as a safe and cost-effective alternative approach to alleviating symptoms associated with digestive dysfunction. This review discusses the pathophysiology of common gastrointestinal disorders and the mechanisms underpinning the regulatory effect of acupuncture...... ReadMore

VL Martynov*, VA Kurilov and NV Kazarina

DOI : 10.32474/CTGH.2019.02.000139

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Ascorbic acid is an indispensable participant in most metabolic processes [1]. It is passively absorbed in the intestine (diffusion, osmosis) along with water and chlorides, but active transport of vitamin is possible, similar to glucose transport [2]. With the insolvency of the bauhinia valve (NBZ) and the development of the syndrome of excessive microbial colonization of the small intestine, the absorption function of the latter suffers avitaminosis “C” develops. One of the objective and accessible screening methods for the determination of vitamin C deficiency was the formulation of a canned sample for capillary resistance [3]. The occurrence of petechial rash after this test allowed to judge the presence and degree of hypovitaminosis. The appearance of petechiae, their size and shape are determined by the degree of “..... ReadMore

Liana Monica Deac* and Gliga VD

DOI : 10.32474/CTGH.2019.02.000138

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Foodborne illness is a common, costly yet preventable public health problem. Every year in the United States, 17 percent of Americans get sick, as a result of consuming contaminated foods or beverages. During the last 3 years 2016-2018, We have observed 183 Food born diseases in our Transylvania region, from Romania, and did a complex epidemiological and clinical study about. On same time, We offer interpretations and conclusions of the cases. Most cases appeared in adults with several chronic illnesses, in 56%, men in 68% from Rural side in 57%. The pathology was relevant in family events, when food contamination occurred probably at any point, from: production, processing, distribution, or any meals preparation with eggs, milk and meat products. There were several clinical forms, from simple one, in 70%, middle one, in 22% to seve..... ReadMore

Jayme Sack and Hari Tunuguntla*

DOI : 10.32474/CTGH.2019.02.000137

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The Gut Microbiome is an integral component to the mental and physical wellbeing of humans. The symbiosis of various microbacteria in cohabitation with our organs is crucial for daily function. In this review article, we reference current literature to demonstrate how important the link between the feelings of our gut is with the rest of our body. We detail critical points of how the gut microbiome affects other systems. The role of maternal microbiome in fetal development diversifies gut flora and enhances defense against stress. The enteric nervous system is intertwined with brain signals and hormonal impulses, which effectively connects two independent systems. The neuropsychiatric involvement with the gut and modulation of psychological disorders can influence gut dysbiosis- a term we define as shifts away from “normal gut mic..... ReadMore

Mirta D Ambra*

DOI : 10.32474/CTGH.2019.02.000136

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The Centers for Disease Control and Prevention (CDC) has received reports from international health centers that Candida auris multi-drug resistant yeast is causing health-associated invasive infections with high mortality. Some strains of C. auris have high minimum inhibitory concentrations (MIC) to the three main classes of antifungals, severely limiting treatment options. C. auris requires specialized methods for its identification and could be mistakenly identified as another yeast when the procedure is based on traditional biochemical methods. The CDC is aware that a strain of C. auris was detected in the United States in 2013 as part of ongoing surveillance. The experience outside the United States suggests that C. auris has a high potential to cause outbreaks in health centers. Given the presence of C. auris in nine countries..... ReadMore

Lizhou Lin*, Rong Wu, Lianfang Du

DOI : 10.32474/CTGH.2019.02.000135

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A 45-year-old man was referral to our hospital for new onset of jaundice and ascites. Symptoms of dark urine, yellow sclera with fatigue and tenderness in the epigastrium started two weeks prior to his admission to local hospital for intensifying yellow sclera and skin with low-grade fever two weeks ago. Liver tests revealed aspartate aminotransferase [AST] 89 [8-40U/L], alanine aminotransferase [ALT] 22 [5-40U/L], total bilirubin [TBIL] 413μmol/L [3.4-11.7μmol/L], direct bilirubin [DBIL] 211.7 [0.0-6.0μmol/L], albumin 25.6 [3.4-5.4g/dL]. Hematological findings revealed white blood cells [WBC] count of 23,950 [4,000-10,000cells/μl], the percent of neutrophile granulocyte [NEUT%] 76.3 [50-70%]. Abdominal MRI showed cirrhosis, ascites and no spleen. He had no serological evidence of hepa..... ReadMore

Vladimir Leonidovich Martynov*

DOI : 10.32474/CTGH.2019.02.000134

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In 37 patients under NBZ and HNDP conditions, 158 biopsy samples were taken from the esophagus SB (N = 29), cardial section of the stomach (N = 20), fundus of the stomach (N = 36), antrum (N = 36), with endoscopic examination. 12 - PC (N = 37). The morphological study revealed inflammatory changes in the mucous membrane of the upper digestive tract in all patients, its superficial inflammation was determined only in 29 preparations, diffuse inflammation (on all layers of the mucous membrane) - in 129 biopsies (82%), the active stage of inflammation - in 102 (65 %), atrophy - in 6, erosion - in 1 case. The obtained data reveal significant morphological changes in the mucous membrane of the digestive tract in conditions of reflux disease. A morphological analysis of the state of the mucous membrane of the esophagus, stomach, and 12-PC, perf..... ReadMore

Martynov VL*

DOI : 10.32474/CTGH.2019.02.000133

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Currently, there is a paradoxical situation where the dominant medical opinion recognizes the harmfulness of dysfunction of such barrier structures as cardia, gatekeeper, Oddi’s sphincter, heart valves, lower extremity vein valves, etc., but ignores the failure of the ileocecal locking device (Bauhinia valve ) as a possible cause of the pathology of the digestive system, as well as various extraintestinal diseases. According to our data, based on the analysis of 976 irrigoscopy, the failure of the bauhinia valve (NBZ) was detected in 56% of cases. Despite these facts, practical and scientific medicine does not pay attention to this phenomenon. In this article, I would like to refer to the NBZ clinic, some etiopathogenetic links in the development of various pathologies of the body from the standpoint of valvular gastroentero..... ReadMore

Nuri Emrah Göret*, Ceren Canbey Göret, Mehmet Gokçeimam, Nalan Turan Güzel, Noyan İlhan and Ömer Faruk Özkan

DOI : 10.32474/CTGH.2019.02.000130

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Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and is one of the major causes of cancerrelated deaths. HCC is reported to be the second most fatal malignancy. The major risk factors for HCC are well known; the known risk factors include hepatitis C virus (HCV) and hepatitis B virus (HBV). Major advances have been reported in the treatment of HCC. Success of early diagnosis increases when these risk factors are identified, and the cases are followed up. It is reported that in the treatment of early-diagnosed HCC cases, ethanol injection or radiofrequency ablation methods as well as surgical resection should be preferred, particularly in cases without liver cirrhosis and in cases where the tumor is restricted. Similarly, liver transplantation may be an option for patients that meet specific criteria..... ReadMore