Lupine Publishers Group

Larbaoui K and Ghouini A*

DOI : 10.32474/CTGH.2022.03.000170

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The distribution of body fat is actually more important than the total amount of fat mass when it comes to cardio-metabolic risk. Abdominal visceral fat is just one low share of fat mass, since the majority of fat is subcutaneous (80% in men, 90% in women), but seems to play a more important role than the rest of the adipose tissue. Indeed, the fatty tissue has 2 compartments with characteristics different metabolisms. In our work, we investigated the influence of age and sex on the propensity for the development of visceral fat in a target population such as obese diabetics. At the end of our study, it clearly appears that age is a risk factor for increased visceral adipose tissue and that men are more exposed than women, although the BMI is higher in the latter...... ReadMore

Javier Orcajo Rincón* and Alonso Farto Juan Carlos

DOI : 10.32474/CTGH.2022.03.000169

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Among the intra-arterial techniques used in primary and metastatic liver pathology, radioembolization with yttrium-90 microspheres has been the one that has evolved most dramatically in recent years and the one that has positioned itself in the earliest stages of management of hepatocellular carcinoma (HCC) in current clinical guidelines [1,2]...... ReadMore

Merit Kase, Clas-Göran AF Björkesten, Veli-Jukka Anttila, Jonna Jalanka, Juuso Arkkila, Perttu Arkkila and Pauliina Molander*

DOI : 10.32474/CTGH.2022.03.000166

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Objectives: The novel coronavirus SARS-CoV2 became a worldwide pandemic in 2020. It is known that patients with inflammatory bowel disease (IBD) are at an increased risk of infection, particularly when on immunosuppressive therapy. The outcomes of COVID-19 in IBD patients remain somewhat unclear. Methods: This Finnish retrospective observational cohort study enrolled 74 patients with an established IBD diagnosis and a confirmed COVID-19 infection. Patient data (age, sex, body mass index, IBD type, biochemical and clinical activity, comorbidities [Charlson comorbidity index [CCI]) and symptoms of COVID-19 were compared with hospitalization due to the COVID-19 infection. Results: We found that older age (p < 0.01) and comorbidities (CCI score higher than one [p < 0.01]) were associated with hospitalization due to COVID-19 ..... ReadMore

N Gokarneshan*, PG Anandha Krishnan, D Haritha, Navya Sudheer and Fousul Inaya

DOI : 10.32474/CTGH.2022.03.000165

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Curcumin is a naturally occurring hydrophobic polyphenol compound. It exhibits a wide range of biological activities such as antibacterial, anti-inflammatory, anti-carcinogenic, antifungal, anti-HIV, and antimicrobial activity. In this research work, antimicrobial curcumin nanofibrous membranes are produce by an electrospinning technique using the Eudragit RS 100 (C19H34ClNO6) polymer solution enriched with curcumin. The morphology and chemistry of the membrane are analyzed using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Kirby Bauer disk diffusion tests are carried out to examine the antibacterial effectiveness of the membrane. Experimental results show that the nano fibers produced are of uniform thickness morphology and curcumin is successfully incorporated into the nanofibrous ..... ReadMore

Raquel Susana Torrinhas, Paulo César Ribeiro, Yassmin Syagha, Anna Carolina Pompermayer Coradelli and Dan Linetzky Waitzberg*

DOI : 10.32474/CTGH.2022.03.000164

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Extra pulmonary symptoms may contribute to poor outcome in COVID-19. We compared the frequency of gastrointestinal and sensory manifestations (GSM) between mild and severely ill patients with COVID-19, alone or combined with Classic Respiratory Manifestations (CRM). Hospitalized patients with COVID-19 (n = 357) were classified according to their disease severity by using a neutrophile/lymphocyte ratio value ≥18 for severe illness. Presence of CRM and baseline clinical data were recorded. Presence of >3 liquid evacuations per day (diarrhea), decreased usual bowel movements (constipation), nausea/vomiting, lack of appetite (anorexia), abdominal pain, loss of taste (dysgeusia) and/or loss of smell (anosmia) were personally recorded by the investigators at the study admission. Severely ill patients (47.3%) presented worse clinical markers..... ReadMore

Hye Won Lee, MD, PhD*

DOI : 10.32474/CTGH.2022.03.000163

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First, the entire tumor volume is obviously reduced. Extravasated mucin, thickened and hyalinized vasculature was often observed. Compared to chemotherapy, which transforms into significant eosinophilic cytoplasm or bizarre morphology, the morphologic change of the tumor cell due to RT is slight. Because the operation is performed several weeks after RT, the tumor portion is replaced by dense fibrotic tissue and often regenerating surface epithelium rather than young fibroblasts. Because of only a tiny number of scattered tumor nests exist, it is difficult to confirm the remaining tumor tissue after RT for research grossly, even an experienced pathologist. So, it is so challenging to collect fresh tissue from an appropriate site. To proceed with research using the remaining tumor tissue after RT, it is appropriate to use formalin-fixed pa..... ReadMore

Benrekia A, Dellal Y, Chott I and Ghouini A*

DOI : 10.32474/CTGH.2021.03.000162

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The role of calcium in nutritional balance and its importance in the proper functioning of the body are widely accepted [1]. Calcium is very common in the diet, however it is milk and its derivatives that exhibit optimal bioavailability [2]. The interest of studying the factors influencing this bioavailability is capital for better management of dietary advice to cover calcium needs; calcium absorption depending on the source of calcium and the nature of the diet [3,4]. Our study aims to define the dietary sources of calcium, the factors influencing the absorbability and its bioavailability in order to adapt the diets to calcium needs. Patients and Methods 100 volunteers of both sexes aged between 20 and 60 years, from the regions of central Algeria (Médéa, Chlef and Ain Defla) participated in the cross-sectional study for 3 months in 2..... ReadMore

Koh Yamashita* and Toru Aizawa

DOI : 10.32474/CTGH.2021.03.000156

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Background: Non-alcoholic fatty liver disease is not simply the hepatic manifestation of obesity and diabetes but also linked to hepatocellular carcinoma. Yet, its effective treatment has not been established. In this study, we evaluated the effect of a short-term administration of luseogliflozin to patients with type 2 diabetes having non-alcohol fatty liver disease. Luseogliflozin is a unique sodium-glucose cotransporter 2 inhibitor which is metabolized in and excreted by the liver in addition to the kidney. Therefore, the drug might possess an additional effect on other agents of the same class which are exclusively metabolized in the kidney.Methods: Using alanine aminotransferase >20 IU/L as a diagnostic basis for non-alcoholic fatty liver disease, 19 patients, not taking alcohol, with type 2 diabetes (male/female 15/4, the median age..... ReadMore