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Review ArticleView abstract PDF Full textObesity is a chronic multifactorial disease characterized by the excessive accumulation of body fat. It increases the risk of other chronic metabolic diseases (e.g., metabolic syndrome, diabetes, cardiovascular diseases, and infertility) and cancer. The global prevalence of obesity is estimated to be 22.4%, and Mexico has one of the highest rates compared to other countries [1]...... ReadMore
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Research ArticleView abstract PDF Full textConflicting data and reports exist on walnut effects on weight management and diabetes control. This experimentally-controlled nutritional study examined the effects of African black walnut (Plukenetia conophora) on weight and diabetes control in experimental diabetic male Wistar rats. The impacts of African black walnut on body weight gain, glycemic tolerance and lipoglycemic profile were evaluated in this study..... ReadMore
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OpinionView abstract PDF Full textOpinion Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood glucose levels and has been an increasing world health problem. It is one of three non- communicable diseases (NCD) worldwide, and the 3rd leading cause of death in humans. Type 2 diabetes is induced by insulin deficiency owing to damaged pancreatic beta cells and insulin resistance. The current therapeutic approaches include repairing damaged beta cells, increasing the sensibility to insulin, retarding carbohydrate digestion, etc., and the relevant medicines such as diformin and acarbose have been developed [1]. However, they usually have single efficacy and some side effects. Notably, most DM may result from unhealthy lifestyles and dietary habits. Therefore, routine prevention rather than therapy has been proposed to be more importan..... ReadMore
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Research ArticleView abstract PDF Full textAbstract Background: It is expected that there will be 366 million diabetics worldwide by 2030, up from 171 million in 2000. Regardless of their level of development, all nations need to do more to prevent and treat diabetes mellitus and its complications. Aim: There was limited data of the adipocytokine leptin’s (Lep) metabolic effects on diabetes patients in Sudan and its connection to the serum lipid profile (Cholesterol, Triglyceride, High density lipoprotein and low density lipoprotein). The purpose of this study is to determine how fasting plasma glucose, glycemic control, lipid profile, and leptin levels relate to each other in Sudanese people with and without diabetes. Methods: Between April 2012 and March 2013, a case-control research involving 200 people was carried out to evaluate the levels of leptin, diabetic profil..... ReadMore
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Mini ReviewView abstract PDF Full textMany studies report increased prevalence of Adrenal Insufficiency (AI) as high as 65% among patients with liver cirrhosis based on measurement of total serum cortisol. However, in liver cirrhosis, the low concentrations of cortisol-binding globulin (CBG) and albumin may underestimate cortisol values leading to a false diagnosis of AI. Measurement of free serum cortisol, the biologically active fraction of cortisol, reflects adrenal function better than total cortisol. Four studies reported that attainment of a free cortisol value of 0.9 μg/dl either at baseline or after corticotropin stimulation rules out AI in patients with liver cirrhosis. Based on these data and until new guidelines are released, the author recommends the measurement of plasma free cortisol in addition to total cortisol to confirm the diagnosis of AI in patients..... ReadMore
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Research ArticleView abstract PDF Full textThe burden of diabetes mellitus is on the rise posing significant threats on health systems, health expenditures and the livelihood of affected patients. In sierra Leone, there has been no data on diabetic admissions. This study intends to close this gap in knowledge and give preliminary data on the profile of patients admitted with diabetes mellitus...... ReadMore
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OpinionView abstract PDF Full textAt the current time, smartwatches are quite being used by diabetic patients which reflects their increased health consciousness and literacy. Diabetes is a chronic metabolic disorder that can be controlled by changing lifestyle...... ReadMore
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Review ArticleView abstract PDF Full textTirzepatide was recently approved in the US for treatment of type 2 diabetes. This agent is currently under investigation for use as anti-obesity agent in individuals without diabetes. In a large phase 3 clinical trial, mean percentage reductions in body weight were 15.0%, 19.5%, 20.9%, and 3.1% with weekly subcutaneous injections of tirzepatide 5 mg, 10 mg, 15 mg, and placebo at 72 weeks, respectively (P<0.001 for all comparisons with placebo)...... ReadMore