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Mini Review
October 09, 2019
Volkov VP
DOI : 10.32474/JUNS.2019.02.000136
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The article describes the observations of renal amyloidosis, developed in the course of long-term antipsychotic therapy of patients with schizophrenia, which can be considered as one of the variants of neuroleptic disease, this severe iatrogenic multiple organ pathology, due to a wide range of the negative side effects of antipsychotic drugs......
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Mini Review
July 30, 2019
Abdul Kader Mohiuddin*
DOI : 10.32474/JUNS.2019.02.000133
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UTIs typically cause women to have a severe urge to urinate, and to do so frequently. It’s also often very painful when they do, and many experiences a burning sensation in their bladder or urethra. Two common factors emerged in urine that had a better ability to resist bacterial growth: it had a high pH—one that’s more alkaline, in other words-and higher levels of certain metabolites formed by gut microbes. Physicians already know how to raise urinary pH with things like calcium supplements, and alkalizing agents are already used in the U.K. as over-the-counter UTI treatments. However, early on in an infection, cells produce a protein called siderocalin that blocks bacterial growth, including the growth of E. coli. Uncomplicated UTIs usually go away with drugs within two to.....
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Case Report
June 13, 2019
Suraj Hegde, Amulya Cherukumudi*, Rajeev TP and Narendra Pai
DOI : 10.32474/JUNS.2019.02.000127
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Carcinoid tumors originate from neuroendocrine cells and have an indolent course. Primary carcinoid of the kidney is rare, as
renal parenchyma is lacking in the enterochromaffin cells. The aetiopathogenesis is not properly understood as there are very few
cases. There are several tests that can be performed pre-operatively, with octreotide scintigraphy being specific. Histopathology
helps confirm the diagnosis, and this is further supplemented by immunohistochemistry. IHC stains positive for cytokeratin and
synaptophysin in case of carcinoid tumors. While medical treatment helps manage the syndromes that maybe associated with
a carcinoid tumor, surgery remains the treatment of choice. These tumors have a low malignant potential, and post-operative
chemoradiotherapy is often not indicated. Here we present a case of a middle-aged fema.....
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Mini Review
June 11, 2019
Youssouf Belazzouz*
DOI : 10.32474/JUNS.2019.02.000126
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Diabetic nephropathy is the result of pathophysiological mechanisms whose best knowledge has offered new therapeutic possibilities and a better life expectancy for both type 1 and type 2 diabetes. Nevertheless, the diabetic kidney may be the seat of other lesions. This is due to diabetics whose positive diagnosis is based on renal biopsy, which is certainly an invasive means but will allow etiological therapeutic management other than glycemic control. diabetic nephropathy is a chronic pathology which therefore requires non-invasive monitoring means that will allow us not only to determine the rate of progression of diabetic kidney disease but also to indicate screening for previously undiagnosed non-diabetic renal lesion. for this reason, biological and morphological means are necessary whose cost-benefit ratio is necessar.....
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Safarik L*, Handrejch L, Koch M, Horáková M and Popílka I
DOI : 10.32474/JUNS.2019.01.000125
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A 58-year-old male with BMI 36,8 was seen due to his allegedly
three months lasting dysuria and traces of blood in his urine. His
renal function was normal, CRP 18,7 and urinary sediment was
flooded with red blood cells, but w/o bacterial infection. There was
no dilatation on U/S, but hyperechoic exophytic mass was seen in
the bladder. The CT scan showed mass, as on Figure 1a. Biopsy from
the mass was taken to disclose sarcomatoid tumor of the bladder.
(Figure 2a). Since there was no secondaries observable in time of CT
scan and on scintigraphy, the radical cystectomy with ileal conduit
was suggested......
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Safarik L*, Handrejch L, Ladman J, Koch M and Horáková M
DOI : 10.32474/JUNS.2019.01.000124
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A 65-year-old woman had been presented with 2 weeks right
lumbar pain and history of two UTI in the past 6 months. On U/S
examination, there was a clearly visible hyperechoic stone in the
central part of the right kidney w/o any obstruction. The CT scan
had proved 14.1 x 6.9mm asymmetrical stone stucked in central
pelvis with post-inflammatory changes around it. (Figure 1). The
patient had allergy on Indomethacin, Ibuprofen and other nonsteroidal pain killers indicating long-lasting and recurrent painful
urological troubles......
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Review Article
May 22, 2019
Omer Abdalla*
DOI : 10.32474/JUNS.2019.01.000123
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The superficial bladder cancer is associated with high risk of recurrence and progression, necessitating lengthy follow up
and repeated endoscopic treatments. White light cystoscopy (WLC) is the current gold standard for the diagnosis, treatment and
surveillance, however the sensitivity and specificity isn’t perfect with risk of missing some tumours. A photodynamic diagnosis
(PDD) using Blue-light cystoscopy is a novel concept proposed to overcome the WLC shortcomings. This critical review synthesizes
the evidences on the effectiveness of Blue light cystoscopy (BLC) for the diagnosis of non-muscle invasive bladder cancer (NMIBC),
and the impact of photodynamic diagnosis on the recurrence rate and progression of superficial bladder cancer......
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Research Article
May 20, 2019
Volkogon Andrii*, Chumachenko Yaroslav, Harbuzova Viktoriia2 and Ataman Alexander
DOI : 10.32474/JUNS.2019.01.000122
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MALAT1 (metastatic associated lung adenocarcinoma transcript 1) is one of the most well-known and most conserved long non-coding RNA (lncRNA). This lncRNA is considered to be the biomarker of PC increased risk, and high expression of its gene correlates with the worst survival rate in patients with PC. Thus, the objective of current study is to analyze the possible link between rs3200401 locus of lncRNA MALAT1 gene and prostate adenocarcinoma (PA) development in Ukrainian population. Venous blood of 184 patients with PA and 66 men without cancer was used for case-control study. MALAT1 rs3200401 polymorphism genotyping was performed by real-time PCR method. The statistical analysis of obtained data was performed using SPSS 17.0. Our data showed that MALAT1 rs3200401 SNP was related to PA, regardless of adjustment for age, smoking status an.....
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Ravi Kant* and Vipin Verma
DOI : 10.32474/JUNS.2019.01.000121
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erum testosterone level steadily decreases with ageing [1]. Low testosterone levels in older adults have been associated with increased adverse cardiovascular (CV) events [2-5]. Testosterone therapy in older men with hypogonadism has consistently shown to improve sexual function, mood, depressive symptoms, muscle and bone strength, and insulin sensitivity and hence, decrease the incidence of type 2 diabetes mellitus (T2DM) and metabolic syndrome as well as favorably improve lipid profile [6-9]. These evidences suggest that exogenous testosterone replacement in men with low testosterone should have beneficial effects on adverse CV outcomes. However, literature is conflicted on CV safety and efficacy of testosterone therapy in older men with hypogonadism. Over last decade, few .....
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Review Article
March 11, 2019
John D Sullivan*
DOI : 10.32474/JUNS.2019.01.000119
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End Stage Renal Disease impacts the lives of over 725,000
Americans and their families. In 1972, despite the cost of supporting
a rapidly growing chronic condition at the time, the United States
initiated a system whereby everyone would be treated that qualifies
for social security benefits, after a waiting period of three years
(Medicare Secondary Payer was slowly extended over the years to
36 months after diagnosis as it currently stands), regardless of age,
providing the platform for the debate of a potential nationalized
health care system that currently seems to be in a period of
uncertainty. However, over three decades through significant
consolidation, the treatment of dialysis via two large provider
chains (one fully integrated) have directed patients to hemodialysis
in the out-patient setting without considering the t.....
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Research Article
March 07, 2019
Alex Oselu Owiti*, Dhananjay Pal and Ashim Mitra
DOI : 10.32474/JUNS.2019.01.000118
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Doxorubicin is a hydrophilic anticancer drug. Due to hydrophilicity, it’s difficult to encapsulate in a hydrophobic core of nano micelles. The main purpose of this study was to develop a hydrophobic ion paring complex (HIP) of doxorubicin using hydrophobic retinoic acid (Vitamin A). The resultant hydrophobic (DOX-RA) complex was utilized to prepare drug-loaded nano micelles by co-precipitation method with penta block copolymer. Nano micelles (DOX-RA/PBNM), was prepared by evaporation rehydration technique. DOX-RA complex was analyzed by H-NMR and FTIR. The nano micelles were analyzed for size and zeta potential using dynamic light scattering (DLS) as well as transmission electron microscopy (TEM). The FT-IR and the H-NMR analyses confirmed the structures of the DOX-RA complex. Mean nanomicellar sizes were .....
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Short Communication
January 24, 2019
Reyes Marin Fernando Arturo*
DOI : 10.32474/JUNS.2019.01.000117
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Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) are recommended in peritoneal dialysis (PD) patients for hypertension or heart failure control [1] Angiotensin II (AII) is an important factor in the development of renal fibrosis due to its hemodynamic effects on glomeruli and stimulation of extracellular matrix proteins synthesis, mediated by TGF b [2]. This may explain why treatment with ACEi and ARBs is renoprotective in patients with diabetic and non-diabetic nephropathy.....
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Research Article
January 04, 2019
Bryan Leung, Jeffrey Wang, Jill Cassaday and Jue Wang*
DOI : 10.32474/JUNS.2019.01.000116
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Tumor lysis syndrome (TLS) is an oncologic emergency that can occur spontaneously or triggered by cancer
treatment. This life-threatening condition is most commonly seen in hematologic cancers but is sometimes described in solid
tumors such as germ cell tumors (GCTs). The objective of this study is to investigate the clinical characteristics and outcomes of TLS
in GCTs......
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Research Article
December 19, 2018
IT Murkamilov*, IS Sabirov, KA Aitbaev, VV Fomin, Zh A Murkamilova, ZR Rayimzhanov, NA Redjapova and FA Yusupov
DOI : 10.32474/JUNS.2018.01.000115
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Aim: The aim of the study was to study the clinical and functional features of renal dysfunction in conditions of hypertriglyceridemia
and remodeling of the left ventricle.
Materials and Methods: 176 patients with chronic kidney disease (CKD) were examined, 111 of them with hypertriglyceridemia
(HTG) in association with left ventricular hypertrophy (LVH) 1st group and 65 patients with LVH in the absence of HTG, matched
by gender and age. Along with general clinical studies, all patients were assessed for lipid spectrum parameters, measurement
of cystatin C in blood plasma, and indicators of arterial stiffness (augmentation index and stiffness) and echocardiography were
analyzed.
Results: In the 2nd group (HTG + LVH), the number of patients with type 2 diabetes mellitus (DM), a combination of hypertension,
coronary heart disease an.....
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Short Communication
October 17, 2018
Abbas Alnaji*
DOI : 10.32474/JUNS.2018.01.000114
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One or two years before I was considering the test of culture and sensitivity C/S in all specimens including urine is the optimal test or the last measure act in reaching of the diagnosis for any. Recently this idea had gone away completely not due to the unknown extent of false negative and positive activity of the antibiotics due to vivo and vitro affairs. It is due to a fact that the revealed bacteria are not the point of our mystery especially in chronic repetitive urinary tract infection which may end in renal failure. The bacteria mentioned in the result forma or paper are what I term them as ‘’ Bad face or Quarrelsome face’’ this means if someone with this adjective is a person who is sent by someone to another someone to e.g. collect a post-due dept the o.....
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Case Report
September 28, 2018
Fred Hodonou*, Josué Avakoudjo and Fouad Soumanou
DOI : 10.32474/JUNS.2018.01.000113
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Urethral ectropion is most common in young girls than elderly woman. The objective in this study was to show anatomopathologic and clinic types of urethral ectropion. We were reported two cases in young girls and one case in 67 years old woman. The clinical symptoms were same. But in the case of old woman we founded right lymph nodes. Biopsy had done in two cases on three. In one of both girls we were discovered after anatomopathology, a vessels thrombosis but in a year-old-woman it was
urethral adenocarcinoma. Management of urethral ectropion depends of age (young girl or elderly woman) and staging of tumor if it was urethral carcinoma......
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Research Article
September 07, 2018
Vladimir Zaichick* and Sofia Zaichick
DOI : 10.32474/JUNS.2018.01.000112
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Benign prostatic hyperplasia (BPH) is an internationally important health problem of the man, particularly in developed countries. The aim of this exploratory study was to evaluate whether significant changes in the levels of Zn and some other trace elements of prostatic fluid exist in the hyperplastic prostate......
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Research Article
July 31, 2018
Jorge Enrique Moreno-Collazos*, Eva Segura Orti, Diana Carolina Zona Rubio and Julián Alberto Moreno
DOI : 10.32474/JUNS.2018.01.000110
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Renal rehabilitation based on early body movement in intensive care units that has been expanding its fields of action from the areas of health promotion, disease prevention, maintenance and rehabilitation of people from the center of study human body movement applied in comprehensive care in intensive care units, which leads to reflection on a reflective theoretical discernment process of conceptual elements that lead to understand the ethical vision of the concept of body and movement in a hospitalization context from the renal environment where key aspects such as pain, care, dysfunctions, limitations and disabilities resulting from
the immobilization process are articulated in the bioethical principles from the praxis of human movement......
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Research Article
July 24, 2018
OL Antipov*, OS Streltsova, DP Pochtin, ID Eranov and EV Grebenkin
DOI : 10.32474/JUNS.2018.01.000109
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Development of novel methods for controlled coarse fragmentation of urinary tract stones may help to minimise the risk of urinary tract infection and prevent the small stone fragments, responsible for residual stone formation, from entering into the calyxcalcification system of a kidney. The experimental results demonstrated that the following parameters of a pulsed laser operating at the 2097 nm (or the 1967 nm) wavelength were optimal for a controlled fractioning of the stones in air: the pulse duration of 20-30
ns, the repetition rate of 200-1000 Hz (or more), and pulse energy of 45-55 mJ. The relatively small pulse energy coupled with the high repetition rate enabled the destruction of concrements into fragments small enough to be removed with the amplatz......
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Mini Review
July 11, 2018
Novikova Maria*, AllazovaSona, Kotenko Oleg andShilov Eugene
DOI : 10.32474/JUNS.2018.01.000108
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To find out the prevalence, and the risk factors conducive to the development of post-transplantation diabetes mellitus (PTDM) after kidney allotransplantation (KAT)......
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