Nanoemulgel Innovative Approach for Topical
Gel Based Formulation
Volume 1 - Issue 2
Malay N Jivani, Chandresh P Patel and Bhupendra G Prajapati*
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- Department of Pharmaceutical Technology, India
*Corresponding author:
Bhupendra G Prajapati, Associate Professor, Shree S.K.Patel College of Pharmaceutical Education and Research,
Ganpat University, Ganpat Vidyanagar, Mehsana, Gujarat, India
Received: February 05, 2018; Published: February 15, 2018
DOI: 10.32474/RRHOAJ.2018.01.000107
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Abstract
The lipophilic nature of majority of newly developed drugs has resulting in poor bioavailability, and pharmacokinetic variations.
The goal of this evaluation is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming
an effective delivery system for poorly water-soluble drugs. Nanoemulgel consist two different systems in which drug containing
nanoemulsionis incorporated into a gel base. The fusion of these two systems makes this formulation advantageous in several
ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several
folds due to the finely distributed oil droplets in gel phase. Simultaneously, it can be targeted more specifically to the site of action
and can avoid first pass metabolism and relieve the user from gastric/systemic incompatibilities. The nanoemulgel drug delivery
system is a formulation related intervention to improve drug absorption and therapeutic profile of lipophilic drugs. An increasing
trend in nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients
due to their non-greasy, convenience spreadability, and easy applicability and good therapeutic and safety profile. Despite having
few limitations, nanoemulgel formulation can be considered as potential and promising candidates for topical delivery of lipophilic
drugs in the future.
Keywords: Nanoemulgel; Topical Formulation; Drug Delivery through skin
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