Immunogeneicity of Recombinant Therapeutic
Interferon Alpha
Volume 1 - Issue 3
Hafiza Rida Farooq Chudhary1*, Ramisha Khan1, Sami Ullah1, Muhammad Bilal1 and Hamid Bashir1
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- 1 Center for Applied Molecular Biology, University of the Punjab, Pakistan
*Corresponding author:
Hafiza Rida Farooq Chudhary, Centre for applied Molecular Biology, 87-West Canal Bank Road, University of the
Punjab, Lahore-53700, Pakistan
Received: March 05, 2018; Published: March 09, 2018
DOI: 10.32474/RRHOAJ.2018.01.000112
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Abstract
Therapeutic recombinant interferons and cytokines are being used to treat different diseases but these proteins can start
immunogenic reactions. These reactions neutralize the effect of therapeutic proteins and make them useless. There are many factors
responsible for causing and effecting immunogenicity including dosage, route of administration, genetic status, and polymorphism
and Allergic responses. The body’s first immune response against recombinant therapeutic cytokines is mediated by innate system,
subsequently activating the adaptive immune system. The key factors in immunogenicity are the glycosylation and aggregated structure
of therapeutic protein that distinguishes the protein/cytokine from self-proteins. There are many ways to reduce immunogenicity like to
decrease the number of epitopes for T-cells or by screening the history of allergies. IFNs are basically proteins in nature many of which
are related both in 3D structure and amino acid sequences. Recombinant Interferons are widely used these days against viral infections
and cancers. In this review the antiproliferative activity and the effects of various recombinant human interferons on the cytotoxic and
cytostatic activity of natural killer cells and monocytes are discussed in detail.
Keywords: Interferons; Neutralizing antibodies; Immunotherapy
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