email   Email Us: info@lupinepublishers.com phone   Call Us: +1 (914) 407-6109   57 West 57th Street, 3rd floor, New York - NY 10019, USA

Lupine Publishers Group

Lupine Publishers

ISSN: 2637-6679

Research and Reviews on Healthcare: Open Access Journal

Research Article(ISSN: 2637-6679)

Evaluation of Pregabaline Efficiency in Reducing Opioid Use and Pain in Post-Operating Patients Subject to Total Knee Arthroplasty Surgery

Volume 4 - Issue 5

Rogério Nascimento Costa1*, Laércio Pol Fachin2, Caio da Silva Ramos Leal3, Daniel Menezes Tenório Cavalcante4, Lorena Fernandes Rosendo de Melo5, Pool Aníbal Alarcón León6 and Thalis Braga Batista7

  • Author Information Open or Close
    • 1Specialist in Orthopedics and Traumatology, Santa Casa de Misericórdia de Maceió, Brazil
    • 2Post-doctorate in cellular and molecular biology, CESMAC University Center, Rua Cônego Machado, Brazil
    • 3Post-doctorate in cellular and molecular biology, CESMAC University Center, Rua Cônego Machado, Brazil
    • 4Resident Physician in Orthopedics and Traumatology, Santa Casa de Misericórdia de Maceió Address: Avenida Moreira e Silva, Brazil
    • 5Anesthesiology Resident Physician, Santa Casa de Misericórdia de Maceió, Rua Prof. Sandoval Arroxelas,
    • 6Resident Physician in Orthopedics and Traumatology, Hospital Santa Casa de Misericórdia de Maceió, Rua Jangadeiros Alagoanos, Brazil
    • 7Medical student at CESMAC University Center, CESMAC University Center, Rua Rodolfo Abreu, Cruz das Almas, Brazil

    *Corresponding author: Rogério Nascimento Costa, Specialist in Orthopedics and Traumatology, Santa Casa de Misericórdia de Maceió, Brazil.

Received: February 03, 2020;   Published: February 18, 2020

DOI: 10.32474/RRHOAJ.2020.04.000198

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Total knee arthroplasty (TKA) is a very efficient surgical process in the treatment of degenerative knee changes. However, this procedure involves extensive tissue trauma, which contributes to the occurrence of severe postoperative pain. In this sense, pregabalin seems to be effective when administered before surgery with significant pain reduction and consequently the amount of opioid used postoperatively. Considering the importance of the subject and considering that there is no work in Alagoas and or Northeast Brazilian populations that justifies the advantages of using Pregabalin in the preoperative period of TKA, this study aims to gather information collected from patients operated at Santa Casa de Misericórdia de Maceió in a period of one year. Thirty-six patients were studied during the research, where four were excluded due to data collection failure. The main indications for TKA were 2 patients with rheumatoid arthritis, 16 with arthrosis and 13 with refractory pain. In this context, pregabalin has recognized side effects, but in the study, it was observed safety in the administration of this drug in the patient group 24 hours before the surgical procedure compared to the patient group 1 hour earlier as shown in Table 1. A greater reduction was observed. of pain according to VAS pain 24 and 48 hours after surgery, in the pregabalin group 24 hours before, in relation to the others. No decrease in postoperative opiod use was observed, as no study group achieved a VAS pain lower than 3 points over the length of stay. Therefore, a larger study with larger patient samples and case-controls is needed to obtain significant results.

Keywords: Total knee arthroplasty; pregabalin;opioid; postoperative; Placebo

Abstract| Introduction| Methods| Results| Discussion| Conclusion| References|

Close

Online Submission System

Drag and drop files here

or

Browse Files
( For multiple files submission, zip them in a single file to submit. For file zipping software Download )