“Crystallo Co Agglomeration” The Novel Approach For Micro particulation

Chandresh P Patel, MalayN Jivani and Bhupendra G Prajapati*

Received: March 14, 2018;   Published: March 20, 2018

DOI: 10.32474/RRHOAJ.2018.01.000115

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Abstract

Coordinate pressure is the favoured technique for tablet producing because of the effortlessness in preparing and its cost adequacy. None the less, to apply coordinate pressure in tablet fabricating, the medication utilized ought to have great stream properties and compaction qualities. Numerous medications are inadequate with regards to these properties thus it isn’t conceivable to pack them specifically into tablets. Crystallo co agglomeration (CCA) is an imaginative procedure created with plans to furnish the medications with great micrometrics and mechanical qualities. The procedure of CCA includes crystallization took after by concurrent agglomeration of the medication with the guide of a good solvent and/or a connecting (bridging liquid) fluid and an awful dissolvable. It is likewise conceivable to consolidate different medications (to get a blend tablet), excipients (e.g. disintigrants for quick dissolving tablets) and diverse polymer blends (to change the medication discharge properties). In the current years, attempts were made to deliver Crystallo co agglomerates of different medications, which were quickly talked about in this article. Despite the fact that extensive scale utilizations of CCA isn’t yet made conceivable, this method gives another line of chances to the tablet fabricating process, guaranteeing ease, single ventured generation of particles with great micromeritics and mechanical characters which can be specifically packed.

Keywords: Crystallo co agglomeration; Good solvent; Bridging liquid; Micromeritics

Abbrevations: CCA: Crystallo Co Agglomeration; GIT: Gastro-Intestinal Tract; CS: Crushing Strength; Tc: Crystallization Temperature; PVP: Polyvinyl Pyrrolidone; HPMC: Hydroxy Propyl Methylcellulose; PEG: Poly Ethylene Glycol; EC: Ethyl Cellulose; PVP: Poly Vinyl pyruvate

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