Salfarina Ramli*

DOI : 10.32474/LOJPCR.2023.03.000161

View abstract PDF Full text

Neurons and brain are lipid-rich and oxygen-rich organs. The oxygen metabolism in the brain leads to the formation of free radicals as by-products, thus both neurons and brain are prone to oxidative and nitrosative stresses...... ReadMore

Miguel F Valente*

DOI : 10.32474/LOJPCR.2023.03.000160

View abstract PDF Full text

The field of anesthesiology is rapidly advancing with the integration of artificial intelligence (AI) technology, particularly in the area of drug repurposing. Repurposing drugs, which involves utilizing drugs for indications other than their original purpose, has become an efficient and cost-effective method of developing new treatments...... ReadMore

Carlos Treceño Lobato*, María-Isabel Jiménez-Serranía, Javier Herradón Muñoz, Elena Valles Martín and José Luis Nájera García

DOI : 10.32474/LOJPCR.2023.03.000159

View abstract PDF Full text

Some statins are metabolised by CYP3A4 pathway and concomitant treatments with potential inhibitors of this isoenzyme could influence in the occurrence of adverse drug reactions (ADR) related to an increase in dose...... ReadMore

Huiquan Gu*, Yanjiao Xie*, Fangyu Wang, Hanqiang Zhang, Longyu Yao, Weimin Chen* and Qiang Liu

DOI : 10.32474/LOJPCR.2022.03.000158

View abstract PDF Full text

Lung adenocarcinoma (LUAD), the most common cause of cancer death in humans, urgently requires specific biomarkers for diagnosis, and treatment. FK506 Binding Protein 4(FKBP4) has been observed to be overexpressed in a variety of cancers, but its role in LUAD is unknown. We aimed to evaluate the role of FKBP4 in LUAD tumorigenesis and prognosis...... ReadMore

Malireddy S Reddy*

DOI : 10.32474/LOJPCR.2022.03.000157

View abstract PDF Full text

The effect of inoculating raw milk with Milk Silo Culture (MSC), developed and manufactured by IMAC, Inc. (International Media and Cultures), on retarding the growth of spoilage and pathogenic bacteria, yeast and molds, and viruses through the activation of milk’s natural Lacto-Peroxidase System (LP), has been evaluated...... ReadMore

Michael Downes*

DOI : 10.32474/LOJPCR.2022.03.000156

View abstract PDF Full text

The increasing monkeypox pandemic has raised many challenges for ongoing clinical trials. These challenges may lead to difficulties in meeting protocol-specified procedures, including administering or using the investigational product or adhering to protocol..... ReadMore

Nahid S Kamal*, Rokon Uz Zaman, Behnam Dasht Bozorg, Sarah Ibrahim, Ahmed S Zidan and Muhammad Ashraf*

DOI : 10.32474/LOJPCR.2022.03.000155

View abstract PDF Full text

Transdermal hormonal drugs without protective covering may pose a risk for skin-to-skin hormone transfer through contact from the dosed to undosed person. Currently, no in vitro methodologies are available to assess the potential risk of skin- to-skin drug transfer...... ReadMore

Sepehr Saberian, Kelsey Paul Stubbs, Chunshu Yang, Sharif Morsalin, Jinbo Fang, Veena N Rao and E Shyam P Reddy*

DOI : 10.32474/LOJPCR.2022.03.000154

View abstract PDF Full text

Each anatomical organ in the body possesses a specialized function. Not only are the functionalities different between organs, but their gross appearance is also visibly discernable. On the contrary, at the cellular level, cells from these different organs operate with strikingly similar molecular pathways. We will examine this characteristic in the case of cancerous prostatic cells and melanocytes and its potential to yield novel therapeutic modalities...... ReadMore