Khalil Salameh*, Abedal khalik Ahmad Khedr, Rajesh Pattu Valappil and Ahmed Hosny Ahmed Tomerak
Received:December 20, 2018 Published: January 02, 2019
Corresponding author:Khalil Salameh, Department of Pediatrics, Qatar
Over use of antibiotics lead to resistance and unwanted sideeffects in newborns. Since 1992, professional societies or public health agencies have issued several generations of recommendations for prevention or management of early-onset neonatal sepsis (EOS) [1-5]. Despite these efforts, recommendations remain inconsistent, clarifications are necessary, local adaptations are common, and compliance rates are low [6-7]. It is common clinical practice to discontinue antibiotic treatment of asymptomatic babies if the blood cultures are negative at 48 hours [8-10]. But it is very common to have prolonged antibiotic courses for more than 48 hours due to delayed release of blood culture, high CRP, abnormal CBC or delayed decision by the Physician to stop antibiotics. In a previous study, McDonald et al.  found this as a common occurrence in neonatal intensive care units. The purpose of this audit is to rationalize the use of antibiotics in symptomatic term babies, with no risk for infection.
This is a retrospective audit to determine the Use of antibiotics
in symptomatic term babies with no maternal risk for infection. Any
full-term infant who was started on antibiotics after admitting to
NICU with various symptoms were included. Preterm babies and
babies with maternal risk for infection (i.e. suspected maternal
chorioamnionitis, PROM >18 hrs, GBS bacteriuria in mother) were
excluded from the audit. Data were collected from January to March
2017 and analyzed with descriptive statistics. A re-audit was carried
out between January to March 2018. 35 patients were included in
the first audit and 22 in the second cycle. As a result of the first
audit cycle following changes in practice were implemented.
a) Infants with mild-to-moderate respiratory findings (flaring, grunting, retractions or tachypnea) immediately after birth may be monitored closely for resolution of transitional behaviors, without initiation of antibiotic treatment unless signs worsen or persist for more than 6 hours without improvement .
b) Serial normal diagnostic tests, such as blood counts or C-reactive protein levels, are highly predictive of the absence of infection and should be relied upon (in addition to culture results) to minimize the duration of antibiotic exposure. However, isolated abnormal hematological or acute-phase-reactant measurements should not justify continuation of empirical antibiotics for more than 48 hours in well-appearing infants with negative culture results.
c) Babies diagnosed as TTN without another differential diagnosis, should not be started on antibiotics unless mild to moderate respiratory signs persist beyond 6 hours. The re-audit evaluated improvement in clinical practice regarding judicious use of antibiotics.
Overall the unit adhered well to the guidelines and there was a significant reduction in use of antibiotics in the unit. None of the babies with mild respiratory distress received Antibiotics before 6 hours in the re-audit, where as a significant number (15 babies (42%), with mild respiratory distress that improved in 6 hours received antibiotics during the first audit period. Similarly, in none of the babies antibiotics were continued for more than 48 hours for high CRP. (4 babies initial CRP were high). During the first audit period, 11% of the cases antibiotics were continued beyond 48 hours just for high CRP. But when compared to the first audit, more number of babies received antibiotics for cases diagnosed as TTN because the local and international guidelines suggest to start antibiotics in babies with respiratory distress persisting for more than 6 hours.
Bio chemistryUniversity of Texas Medical Branch, USA
Department of Criminal JusticeLiberty University, USA
Department of PsychiatryUniversity of Kentucky, USA
Department of MedicineGally International Biomedical Research & Consulting LLC, USA
Department of Urbanisation and AgriculturalMontreal university, USA
Oral & Maxillofacial PathologyNew York University, USA
Gastroenterology and HepatologyUniversity of Alabama, UK
Department of MedicineUniversities of Bradford, UK
OncologyCirculogene Theranostics, England
Radiation ChemistryNational University of Mexico, USA
Analytical ChemistryWentworth Institute of Technology, USA
Minimally Invasive SurgeryMercer University school of Medicine, USA
Pediatric DentistryUniversity of Athens , Greece
The annual scholar awards from Lupine Publishers honor a selected number Read More...
We know the financial complexity of Individual read more...
The annual scholar awards from Lupine Publishers honor a selected number read more...