“Use Judiciously, or I Will Be Useless” A Clinical
Audit on Use of Antibiotics Within First 72 hrs of
Life in Symptomatic Term Babies With no
Maternal Risk for Infection
Volume 2 - Issue 1
Khalil Salameh*, Abedal khalik Ahmad Khedr, Rajesh Pattu Valappil and Ahmed Hosny Ahmed Tomerak
Received: December 20, 2018; Published: January 02, 2019
DOI: 10.32474/PAPN.2019.02.000128
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Background
Over use of antibiotics lead to resistance and unwanted sideeffects
in newborns. Since 1992, professional societies or public
health agencies have issued several generations of recommendations
for prevention or management of early-onset neonatal sepsis (EOS)
[1-5]. Despite these efforts, recommendations remain inconsistent,
clarifications are necessary, local adaptations are common, and
compliance rates are low [6-7]. It is common clinical practice
to discontinue antibiotic treatment of asymptomatic babies if
the blood cultures are negative at 48 hours [8-10]. But it is very
common to have prolonged antibiotic courses for more than 48
hours due to delayed release of blood culture, high CRP, abnormal
CBC or delayed decision by the Physician to stop antibiotics. In
a previous study, McDonald et al. [11] found this as a common
occurrence in neonatal intensive care units. The purpose of this
audit is to rationalize the use of antibiotics in symptomatic term
babies, with no risk for infection.
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