Synbiotic Therapy in Infantile Colic - A Clinical Trial Volume 4 - Issue 3

Peymaneh Alizadeh Taheri¹*, Armen Malekian Taghi² and Mandana Motevaselian³

• ^*1Department of Neonatology, Tehran University of Medical Sciences, Bahrami Children Hospital, Tehran, Iran
• ²Department of Gastroenterology, Tehran University of Medical Sciences, Bahrami Children Hospital, Tehran, Iran
• ³Department of Pediatrics, Tehran University of Medical Sciences, Bahrami Children Hospital, Tehran, Iran

Received:May 19, 2023   Published: May 26, 2023

Corresponding author:Peymaneh Alizadeh Taheri, Department of Neonatology, Tehran University of Medical Sciences, Bahrami Children Hospital, Tehran, Iran

DOI: 10.32474/PAPN.2023.04.000188

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Background: Infantile colic is a common referral problem to pediatric clinics. The last criteria for the diagnosis of colic are the Rome IV criteria. There are different recommendations for the treatment of infantile colic but the response to each treatment is variable and no definite treatment has been recognized for this problem yet.

Aims: According to our last research, few clinical trials have surveyed the efficacy of synbiotics containing multi-strain probiotics in infantile colic, so the present study was performed.

Material and Methods: This study was performed on 60 infants (65% boys, mean age 62.26±15.6 days; mean birth weight: 3150±420 g) with the diagnosis of infantile colic. The infants of group A were randomly administered a synbiotic containing B. infantis, L. reuteri, L. rhamnosus, and fructooligosaccharides (FOS) (PediLact® [Zist-Takhmir Co., Tehran, Iran] drop), while group B received placebo (Dimeticon) [Toliddaru Co., Tehran, Iran]). The primary outcome was the response rate of each group, and the secondary outcome was the adverse effect of each drug.

Results:The response rate to the synbiotic containing multi-strain probiotics was significant after each week of intervention to the fourth week of intervention (Intragroup P-value <0.001). The response rate was also significant in synbiotic group after each week of intervention to the fourth week of intervention (Intergroup P-value <0.001) in comparison with Dimeticon. There was no adverse effect through each intervention.

Keywords:Synbiotics; infantile colic; crying; pedilact; fructooligosacharide

Abstract| Introduction| Methods| Results| Conclusion| Acknowledgment| Additional Points| Author conflicts of interest| Funding| Authors’ Contributions| References|