Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the development of
autoantibodies and immune complexes associated with a variety of clinical manifestations and tissue damage. SLE is the production
of reactive antibodies against the body’s own cells. SLE is multifactorial and most likely involves complex interactions between
genetic, environmental, and hormonal factors. There is an aging process in immune cells due to changes in the innate and adaptive
immune system compartments. This phenomenon is known as Immunosenescence, also occurs on autoimmune. One of the
characteristics of elderly people is their inability to respond to vaccines and infections properly.
Discussion This situation also occurs in patients with systemic lupus erythematosus (SLE). In SLES patients, the aging of
the immune system is the concept of inflammation; a state where there is a chronic pro-inflammatory status, characterized by
increased levels of pro-inflammatory cytokines such as TNF, or IL-6, thereby stimulating a decrease in IL-2 and IFNγ and an increase
in IL-10. Clotting factor and acute phase reactants under constant conditions. These biomarkers correlate with the incidence of
various age-related diseases, such as heart disease, cognitive decline, cancer, and other physical disabilities. Immunosenescence
and inflammation are the result of disruption in the cellular immunity properties of the innate and adaptive immune.
Conclusion: Defect production of T cells and B cells in autoimmune disease could results immune aging. This phenomenon
causes neutrophil activation, forming antibody DNA consisting of immune complexes resulting in severe inflammation and tissue
damage, as periodontal disease in oral cavity.