Therapeutic Potential of TRPM Modulator
Volume 4 - Issue 4
Nitin Rawat, Hemprabha Tainguriya and Anil Kumar*
- Pharmacology Department, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University,
India
Received: September 23, 2020; Published: October 06, 2020
Corresponding author: Anil Kumar, Professor of Pharmacology, Former Dean, Faculty of Pharmaceutical Sciences, University
Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh, India
DOI: 10.32474/OJNBD.2020.04.000192
Abstract
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Abstract
Transient Receptor Potential of the family Melastatin (TRPM) is a group of nonselective cation channel, engaged in various daily
activities of the body. The family’s first member (TRPM1) was cloned in 1998 capable of supressing the tumour in melanocytes of
skin. Soon after TRPM1 was discovered, another family member was discovered, that includes TRPM2 (channel sensitive to oxidative
stress present in microglial cells), TRPM3 (channel activating renal homeostasis that is activated by sphingosine), TRPM4/5 (Ca+2
activated sister channel involved in conduction of monovalent cation), TRPM6/7 (chanzymes related to Mg+2 homeostasis), TRPM8
(thermosensitive Ca+2 permeable channel). This review will summarize activation of key structural features mechanism and
therapeutic potential of drug modulating TRPM channels.
Keywords: Transient Receptor Potential (TRP) Channels; TRPM Modulators; Neurodegenerative Diseases; Cancer
Abstract|
Introduction|
TRPM Channel and its Structural Features|
Physiological and Pathophysiological Role of
TRPM Channels in Various Diseases|
Conclusion|
References|