The Pathogenesis and Association between Human Herpesvirus and Central Nervous System Diseases Volume 5 - Issue 1

Liu Dong¹, Li Zhongjun² and Zhang Shuai³*

• ¹Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China
• ²Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
• ³Department of Neurosurgery, Beijing Jingmei Group General Hospital, Beijing, China

Received: January 21, 2021;   Published:February 02, 2021

Corresponding author: Zhang Shuai, Department of Neurosurgery, Beijing Jingmei Group General Hospital, Beijing, China

DOI: 10.32474/OJNBD.2021.05.000204

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Abstract

Human herpesvirus (HHV) is a large class of double stranded DNA virus that can cause a generalized rash after infection, mainly cause skin and mucous membrane damage, leading to the oral herpes, herpes dermatitis, genital herpes, et al. The virus will be longstanding with the host after infected, latent infection and cyclical recurrence are the pathogenic characteristics of HHV. Intermittent replication is one important reason that the virus cannot be completely eradicated by body immune system. HHV infection can stimulate the body’s inherent and acquired immune response, including the inherent immune cells, cytokines and T lymphocytes. The host cells infected the virus can inhibit the replication and proliferation of HHV by inducing apoptosis. In recent decades, with the deepening research and understanding of HHV, the virous is associated with some Central Nervous System Diseases (CNS), such as intracranial tumors, encephalitis and neurodegeneration diseases and so on. This paper will review the pathogenesis and association between CNS diseases and HHV for colleague’s reference.

Keywords:Human Herpes Virus; Central Nervous System Diseases; Pathogenesis

Abstract| Introduction| The Structure and Pathogenesis of HHV| The Subtype and Pathogenesis of HHV Subfamily| Conclusion| References|