Background: There is no effective therapy for many neurological disorders associated with significant neurological damage
such as kernicterus. Patients with Kernicterus (Chronic bilirubin encephalopathy) which is a neurological dysfunction resulting from
exposure of the brain to severe hyperbilirubinemia mostly during the neonatal period continue to experience significant disability.
There is no known therapeutic intervention that can obviously improve this condition. The aim of this paper is to describe a novel
therapeutic approach which in two months produced marked improvement of the neurological dysfunction caused by kernicterus.
Patients and Methods: A girl with kernicterus was not speaking and not saying any word. She was lacking the balance (coordination)
without obvious muscle weakness. She was unable to maintain the sitting posture on a chair for few minutes. She
was unable to maintain straight standing posture when supported on chair at all. She had difficulty in holding things. The girl was
treated with a novel therapeutic approach including two courses of intramuscular cerebrolysin and intramuscular citicoline.
Results: After treatment the first month of treatment, speech development was initiated, and she was saying few words. She
was able to sit normally on the chair and maintaining the sitting posture indefinitely. She was able to maintain more straight stable
standing posture without holding a chair and with the ability to hold things at the same time indicting improved coordination. She
also developed improved ability to hold small things like a pen. After the second month of treatment, the girl was able to stand alone
and was making few steps slowly holding furniture. After treatment the second course of treatment, the girl was able to stand alone
and walk rapidly holding furniture. Treatment was not associated with any side effects.
Conclusion: The novel use of intramuscular cerebrolysin and citicoline in a patient with kernicterus was safe and effective.