Drug addiction is a chronic, relapsing brain disorder. Pathological neuroplasticity changes in the brain areas involved in cognition, memory and reward lead to intensely psychological dependence on abused drugs in addicts. The key to drug addiction treatment is how to prevent the high relapse rate after withdrawal. Mammalian Target of Rapamycin (mTOR) signaling pathway exists widely in vivo and has variously complex physiological function, which can regulate drug memory by affecting synaptic plasticity. This mini-review discussed the role and research progress of the mTOR signaling pathway in drug memory.