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ISSN: 2637-6628

Online Journal of Neurology and Brain Disorders

Research Article(ISSN: 2637-6628)

Distribution of Multilayered Fiber Terminals in the Human Cerebellar Cortex. Visualization by Immunohistochemistry for Histamine

Volume 2 - Issue 3

Anna Rizzi, Matteo Saccia and Vincenzo Benagiano*

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    • Department of Basic Medical Science Neuroscience and Sensory Organs, University of Bari, Italy

    *Corresponding author: Sergei Pakriev, Department of Psychiatry, Izhevsk State Medical Academy, Izhevsk, Russia

Received: February 12, 2019 ;   Published: February 21, 2019

DOI: 10.32474/OJNBD.2019.02.000139

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The distribution of histamine in the human cerebellar cortex was studied by light microscope immunohistochemistry using a rabbit polyclonal antibody anti-histamine. In all layers of the cerebellar cortex, were revealed punctate immunoreactive elements related to putative histaminergic nerve terminals. These findings provide insights into the existence of a histaminergic system in the human cerebellar cortex, presumably involved in the cerebrocerebellar circuit, the feedback circuit through which the cerebellum is widely connected with the neocortex and the hypothalamus and intervene in the regulation of motor and non-motor functions.

Keywords: Cerebrocerebellar Circuit; Hypothalamus; Cerebellum; Multilayered Fibers; Histamine

Abstract| Introduction| Material and Methods| Results| Discussion| References|