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ISSN: 2637-6628

Online Journal of Neurology and Brain Disorders

Research Article(ISSN: 2637-6628)

Correlation Between Indicators of Blood Cells Aggregation Level and the Number of Lymphoblasts and Monocytes in Patients with Glioblastomas Volume 5 - Issue 4

Pedachenko Eugene Georgievich1, Morozov Anatolyi Nikolaevich1, Gridina Nina Yakovlevna1*, Glavatsky Alexandr Yakovlevich1, Kot Larisa Anatolievna1, Ushenin Yuryi Valentinovich2, Draguntsova Nataliya Gennadievna1, Khristosenko Roman Vasilyevich2 and Belousova Anna Dmitrievna1

  • 1Institute of Neurosurgery, A P Romodanov Institute of Neurosurgery, Kiev, Ukraine
  • 2Institute of Semiconductor Physics , V E Lashkaryova, Kiev, Ukraine

Received:May 13, 2021   Published:May 21, 2021

Corresponding author:Gridina Nina Yakovlevna , Institute of Neurosurgery, A P Romodanova, Kiev, Ukraine

DOI: 10.32474/OJNBD.2021.05.000220

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The inflammatory process is an important part of malignant brain gliomas progression mechanism. The inflammation induced by tumor tissue necrosis is called tumor-associated inflammation (TAI). Taking into account the leading role of TAI in the gliomas progression, the aim of the work was to study the correlation between the indicator of the inflammatory process and the number of potential blood stem cells - lymphoblasts and monocytes. These cells are involved in the processes of tissue regeneration in the wound focus after surgery for the removal of tumors. The wound tumor focus was named “non-healing wound” as a result of the activation of TAI which prevents the formation of normal tissue cytoarchitectonics by blood stem cells, which are exposed to the destructive effects of inflammation factors. Studies have found a negative correlation between the indicators of stage II inflammation - the level of blood cells aggregation, measured in SPR (surface plasmon resonance) units using the highly sensitive Plasmon biosensor, and the number of lymphoblasts, formed in the RBTL test in vitro, and Mid cells, containing monocytes in peripheral blood in patients with glioblastomas.

Keywords: Glioblastomas; Tumor-Associated Inflammation; Regeneration; Blood Cells Aggregation; Lymphoblasts; Monocytes; Negative Correlation

Abstract| Introduction| Materials and Methods| Results and its Discussion| Conclusion| References|