Synaptic plasticity is a biological system of specific pattern of synaptic activity result in changes in synaptic strength. This
influence puberty, pregnancy hormones, sensory experiences, and brain disorders. Long-term synaptic plasticity is accompanied by
protein synthesis and trafficking, leading to structural changes of the synapse. Increasing evidence connects the terminal synaptic
changes with potential propagation in adolescent and pregnancy. We investigate on the synaptic structural plasticity, which has
mainly been studied with in vivo two-photon laser scanning microscopy. We also discuss how a different type of synapses, the multicontact
synapses associated with pregnancy.