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Brinderjeet Kaur* and Rateesh Sareen

DOI : 10.32474/IGWHC.2022.05.000215

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Infertility is on increase with rising trend observed in carrier-oriented couples. The influence of infertility can be immense and devastating. The impact affects the social wellbeing with loss of self-esteem, disappointment and depression. The investigations of many such couples do not exhibit any perceptible cause and are labeled as ‘unexplained infertile’ - which accounts for around 15-30 percent of the cause of infertility. Such couples have normal ovulatory function, normal semen analysis, normal tubal patency and normal endometrial cavity. It is often hard to explain to such couples their inability to reproduce. The vital step in conception is the efficacious implantation which necessitates a normal and functioning embryo at developmental stage of blastocyst, a receptive endometrium and a synchrony between embryonic and maternal..... ReadMore

Michael Tchirikov*, Constanze Scheler, Martin Gericke, Andreas Wienke and Michael Ente Zami*

DOI : 10.32474/IGWHC.2022.05.000214

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Background: Chorioamniotic separation (CAS) at the time of amniocentesis is a risk factor for an elevated postprocedural complication rate after standard amniocentesis and should be excluded before amniocentesis. Objectives: The aim of this study was to quantify procedure-related risks after amniocentesis (AC) with a 29G-needle in cases of chorioamniotic separation (CAS) and evaluation of perinatal outcome in CAS after 15 weeks’ gestation (GW). Materials and Methods: Retrospective analysis of genetic amniocentesis with an atraumatic 29G-needle after 15 completed GW in pregnancies, in which the fetal membranes were not fused yet. Included into the study were women with at least 15 completed weeks of gestations referred for second trimester amniocentesis to identify fetal chromosomal aberrations aged 16 to 44 years. Results: 437 Amn..... ReadMore

Gérard Zwang*

DOI : 10.32474/IGWHC.2022.05.000213

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It is Konrad Lorenz, who described the period of sensitivity necessary for the epigenetic maturation of certain biological functions. The orgasmic reflex, the foundation of the erotic function, is one of these phenomena which can only emerge during a sensitive period of childhood. It is the individual, guided by the situation his hands, and by grooming, who discovers the power of the orgasmic zones. Thus, a first infantile phase of development, autoerotic, is imposed on the use of the external genitalia. Before the access to the second, adult, heteroerotic phase. Ignoring, blaming or antagonizing this autoerotic phase is not only a general fault of civilization, mentioned here, with sometimes dramatic consequences. but also, a scientific error...... ReadMore

Kariman Ghazal*, Eva Koulaymi, Mayssaloun Khairallah, Ahmad Beyrouti, Loubna Sinno, Jihad El Hassan and Georges Yared

DOI : 10.32474/IGWHC.2022.05.000212

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Objectives: The objective was to describe and compare self-reported changes in the menstrual cycle in females who had COVID-19. Methods: This was a cross sectional study conducted through an online questionnaire between January 1, 2021, and September 30, 2021. Included were females aged between 13 and 52 years who previously acquired COVID-19. Participants were divided into two groups; one group were females who experienced change in their menstrual cycle following COVID-19 infection and the other group were those who did not have any change. Results: A total of 341 participants were included, 183 (53.7%) experienced change in their menstrual cycle. The mean age was 31.01±8.97 years in those without change and 32.21±9.09 years in those who had changes. Ninety (57.0%) in the unchanged cycle group had co..... ReadMore

Kariman Ghazal*, Ahmad Bayrouti, Jihad El Hasan and Georges Yared

DOI : 10.32474/IGWHC.2022.05.000211

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Endometriosis has a broad spectrum of presentation The purpose of this article is to familiarize the gynecologist with the wide spectrum of pelvic and extra pelvic endometriosis and to review the distinctive imaging findings. Its clinical diagnosis could be challenging since it is often confused with infection, abscess, hematoma, and tumors. We hereby report a series of multiple endometriosis presentations appearing during pregnancy, at episiotomy and perineum, as well as after cesarean delivery and hysterectomy. The primary modality of treatment is surgical removal of the lesions, though hormonal therapy is also applied...... ReadMore

Zheng Haiyan*

DOI : 10.32474/IGWHC.2022.05.000210

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Obstetrics and gynecology nursing as a nursing major of a core course, is a professional, practical, technical strong compulsory course and backbone course, teaching should be combined with theory and practice, strengthen students’ ability and practical application ability, improve students’ professional quality. In this paper, aiming at the problems existing in the gynecology and obstetrics nursing theory teaching, based on “Internet + Learning pass “ teaching method reform, through online hybrid teaching mode, strengthen the course ideological education, to develop before diagnosis, class earnestly, after class three link to promote students’ knowledge, set up a communication to discuss learning model, and through the creative thinking training. Comprehensively improve students’ learning abi..... ReadMore

Loni Sneed, Jingyao Xu, Kirat Sandhu, Cyra Mia Bailey Cottrell, Titi Shobayo, Aniah Daniels, Jyothika A Desai, E Shyam P Reddy and Veena N Rao*

DOI : 10.32474/IGWHC.2022.05.000209

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The BRCA1 gene has been well studied for its role as a tumor suppressor by repairing double-stranded DNA via homologous recombination during cell replication. Thus, an aberrant BRCA1 gene has extensively been shown to increase the risk for breast cancer and certain ovarian cancers through years of research. However, BRCA1’s unique relationship to female fertility is not as well researched. Studies have shown that a lower ovarian primary follicle pool has been associated with BRCA1 mutations and increased infertility rates, but the molecular link has yet to be fully elucidated...... ReadMore

IV Kachanov* and IA Kuznetsova

DOI : 10.32474/IGWHC.2022.05.000208

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The purpose of the study: To study the concentration of iron-containing proteins in menopausal women diagnosed with breast cancer and determine their role in the immune processes of the body...... ReadMore

Stefania Andrascikova*, S Alena Schlosserova and Alexandra Archalousova

DOI : 10.32474/IGWHC.2022.05.000207

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Background: Assessment of risk factors affecting women’s health during pregnancy has been in the Centre of several research-ers’ interest. However, there is a lack of studies investigating risk factors affecting women’s health during pregnancy in Slovakia. Methods: A cross-sectional survey was used to investigate relationships among risk factors (age, genetics, education, social status and parity), selected laboratory parameters, and BMI during pregnancy. The study sample consisted of 104 pregnant women (whose health histories had detected risk factors) from four hospitals in the East Slovakia region. Data were collected by means of analysis of medical documentation and obtained during ward rounds., multi-factor ANOVA procedure was performed for the pur-pose of statistical analysis...... ReadMore

Yang Rao, Wenwen Zhang, Dan Li, Xiao Li, Yaomei Ma* and Pengpeng Qu*

DOI : 10.32474/IGWHC.2022.05.000206

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Purpose: To investigate the effect of Circ_0001529-mediated miR-578-CDC25A axis on the growth of ovarian cancer cells in vitro and in vivo. Method: The expression differences of Circ_0001529 in ovarian cancer tissues and paraneoplastic tissues were first analyzed; Circ_0001529 overexpression plasmids and interference plasmids were constructed and transfected into SKOV3 cells and SiHa cells, respectively, followed by MTT assay, flow cytometry, and immunofluorescence to detect cell growth, proliferation, and apoptosis. The binding relationship between Circ_0001529 and miR-578, or miR-578 and CDC25A was verified by online prediction site and dual luciferase assay, and CDC25A overexpression plasmid and interference plasmid were constructed and transfected into SKOV3 cells and SiHa cells, respectively. qRT-PCR and..... ReadMore

Changjiang Yu, Yangling Zhang, Jingjing Huang, Shengli Zeng, Fan Chen and Jiangming Xiang*

DOI : 10.32474/IGWHC.2022.05.000205

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Purpose: To investigate the mechanism by which UBE2C affects breast cancer tumor progression through regulation of Bcl2. Methods: qRT-PCR to detect the expression of UBE2C in breast cancer cells MCF-7 and normal breast epithelial cells MCF-10A; Western blot to detect the expression of UBE2C and Bcl2 protein in breast cancer cells; CCK8 cell viability assay and clone formation assay by plasmid or siRNA transfection to overexpress or knockdown UBE2C proliferation of breast cancer cells; Co-IP to verify the interaction between UBE2C and Bcl2. Results: UBE2C and Bcl2 were significantly highly expressed in breast cancer cells; overexpression of UBE2C promoted breast cancer cell proliferation and knockdown of UBE2C inhibited breast cancer cell proliferation; UBE2C interacted with Bcl2, and UBE2C promoted breast cancer cell prolifera..... ReadMore

Ajit K Saxena*, Mukta Agarwal, Meenakshi Tiwari, Ujjwal Kumar, Shailendra K, Lovely Sinha and Chandan K Singh

DOI : 10.32474/IGWHC.2021.05.000203

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Reproductive health is a serious and mounting problem in the world, where several factors including climate changes such as global warming resulting in change in sperm quantity according to world health organization [1]. The pathogenicity of infertility is highly complex phenomenon affecting approximately 1:20 males during reproductive age due to unknown genetic and epigenetic factors [2,3]. The role of complex chromosomal rearrangement (CCRs) and high incidence of mosaicism are well known in azoospermia patients [4]. More than 20% of De novo mutations of USP9Y and PCDH11Y genes were observed in both heterozygous and homozygous conditions that encodes amino acid arginine guanine, isoleucine and leucine modulates early transcription factor such as Sox9 gene in non-obstructive azoospermia (NOA) cases. Similarly, Sox9 gene expression is esse..... ReadMore

Siniša Franjić*

DOI : 10.32474/IGWHC.2021.05.000202

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Bacterial vaginosis (BV) is a condition in which the normal balance of bacteria in the vagina is disrupted, and overgrowth of certain bacteria occurs [1]. BV can be transmitted sexually and is considered a sexually transmitted infection; however, it can also occur in the absence of sexual contact. BV primarily affects women who are sexually active; however, it is unclear what role sexual activity plays in the development of BV. BV is the most frequently diagnosed symptomatic vaginitis in U.S. women. BV affects 29% of all women aged 14 to 49. Of women who are affected with BV, 19% are not sexually active, and 25% are pregnant. Vaginal Pain In the busy surgery, the temptation to treat without examining can be great, as the doctor may well feel safe in the assumption that common things being common it will be a case of candida [2]. When symp..... ReadMore

Seun Ayoade*

DOI : 10.32474/IGWHC.2021.04.000200

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I propose a new, safe, novel, and instantaneous method of abortion viz-the handheld electric zapper/catheter. At present there are two methods of abortion in existence-the surgical and the medical. I propose the electrical. Termination should come instantaneously, and this method should be equally effective for a new zygote and a nine-month-old foetus. The electric zapper could be applied externally while the electric catheter could be applied internally via the vagina. The mother could be locally anaesthetized or wide awake. She will feel little to no discomfort. Voltage will be carefully selected to that effect. We must remember that the fetus is much less resistant to electric shock than the mother. In one study for example 15 pregnant women suffered electric shocks and all but 4 lost their pregnancies. Of the 4 that survived, only one..... ReadMore

Anubha Bajaj*

DOI : 10.32474/IGWHC.2021.04.000199

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Significant bacterial ingress due to trauma, ischemia or foreign bodies with adherent microorganisms may infiltrate sites of exposed bone and engender osteomyelitis. An estimated 50% instances may occur due to unknown bacteria [1,2]. Osteomyelitis is generally detected between 2 years to 12 years although no age of disease emergence is exempt. A male predominance is exhibited with a male to female proportion of 3:1 [1,2]. Frequently the lower extremities, vertebral column, radial styloid and sacroiliac joints are incriminated. Location of infection is contingent to age of incriminated individual as altered vascularization is enunciated in diverse bone segments. Commonly, metaphysis or epiphysis in neonates, metaphyseal region in children and epiphyses or subchondral region of adult subjects are implicated in Figure 1. Distal and proximal ..... ReadMore

Leanne Morgan and Ralph Roberts*

DOI : 10.32474/IGWHC.2021.04.000197

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Recent legal changes restricting abortion in Texas have focused attention on the continuing issue of a lack of reproductive freedom for women. This affects women in many countries throughout the world including Northern Ireland. The 1967 Abortion Act, which established legal access to abortion in the rest of the United Kingdom (UK), never applied in Northern Ireland (NI). Prior to a recent change in the law, abortion was illegal in NI with the exception of very limited circumstances. The options for women were either to continue with the pregnancy, travel to services in Great Britain or to access abortion pills from the internet. The choices available to NI women have increased since the decriminalization of abortion on 22 October 2020, following the passing of the Northern Ireland (Executive Formation etc.) Act 2019. However, despite thi..... ReadMore

MM Niang*, A Mbodji, F Samb, M Thiam, ED Sy and CT Cisse

DOI : 10.32474/IGWHC.2021.04.000196

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Immediate postpartum hemorrhage (IPPH) is the leading cause of maternal mortality and morbidity in developing countries, with nearly 130,000 deaths each year and 2.6 million complications worldwide [1-3]. In Senegal, according to an assessment of emergency obstetric and neonatal care carried out between July 2012 and June 2013, the maternal mortality ratio was 222.9 per 100,000 live births, and haemorrhage was a direct cause of maternal death in 44,2% (SONU survey). In our limited resources countries, particularly in Senegal, available therapeutic means are: uterotonics (oxytocin, misoprostol), conservative surgery (triple arterial ligation, uterine artery ligation, hypogastric artery ligation, B- Lynch and Cho) and hysterectomy of hemostasis. These surgical treatments are not feasible by all health providers and are not available at the ..... ReadMore

Vikram Khanna*

DOI : 10.32474/IGWHC.2021.04.000195

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Introduction: Cervical cerclage has been advocated in cases of ‘cervical incompetence’. There is very little evidence on the material to be used for cerclage. Here we have used nylon wool over semicircular needle for cervical cerclage. Material and Methods: 30 patients were included in the study. After a written informed consent, the patient was then taken for cervical cerclage suture application. The material used was dark colored nylon wool. The primary outcome was live birth rate of the baby where as the secondary outcome parameters included period of gestation at delivery, mode of delivery, length of hospitalization of the baby, NICU if required for the baby, requirement of another cerclage in subsequent pregnancies and the timing of removal of cerclage...... ReadMore

Ranjana Khanna, Parul Gupta Khanna* and Vikram Khanna

DOI : 10.32474/IGWHC.2021.04.000195

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Cervical cerclage has come a long way since it was first performed in 19021. It has been advocated in cases of ‘cervical incompetence’ which is a term defined by ACOG as “the inability of uterine cervix to retain a pregnancy in the second trimester in the absence of uterine contractions”2. Cochrane review has suggested the reduction in the neonatal mortality following cerclage3 [2-4]. Different terms have been used for different types of cerclages. These include1 History indicated cerclage - It is a prophylactic cerclage done in an asymptomatic woman at 12-14 weeks with history of 3 or more premature labour or mid trimester abortions. Ultrasound-indicated cerclage - On USG done between 14-24 weeks of gestation if the cervical length is less than 25 mm without any exposed fetal membranes then cerclage can be performed Rescue cercla..... ReadMore

Antonia Vollrath

DOI : 10.32474/IGWHC.2021.04.000194

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