The Significant and Profound Impacts of the Studies on the Rate of Diffusion-Controlled Reactions of Enzyme

Kuo-Chen Chou*

• Gordon Life Science Institute, Boston, United States of America

Received: September 19, 2020;   Published: October 06, 2020

*Corresponding author: Kuo-Chen Chou, Gordon Life Science Institute, Boston, Massachusetts 02478, United States of America

DOI: 10.32474/SJFN.2020.03.000163

Abstract PDF

In this short review paper, the significant and profound impacts of the enzyme diffusion-controlled reactions have been briefly presented with crystal clear convincingness.

Keywords:Enzyme fast reactions; Upper limit; Spatial factor; Force field factor; Active site; Substrate; Role of the main protein

About 47 years ago a very important paper on the rate of diffusion-controlled reactions of enzyme [1] was published. According to its deduction, the upper limit of enzyme-substrate reaction is 1010/Msec, which is one order of magnitude higher than the conventional estimation by Manfred Eigen [2], who won the 1967 Nobel Prize in Chemistry for the work on measuring fast chemical reactions [2]. The upper limit has been confirmed by a series of follow-up studies [3-10]. It is indeed very significant and profound for such a breakthrough or revolution in enzyme fast reaction. Particularly, it has also been supported by the eight masterpiece papers of the then Chairman of the Nobel Prize Committee [7, 8, 11-16].

1. Chou KC, Jiang SP (1974) Studies on the rate of diffusion-controlled reactions of enzymes. Scientia Sinica 17(5): 664-680.
2. Eigen M, Hammes GG (1963) Elementary steps in enzyme reactions (as studies by relaxation spectrometry). Advances In Enzymology and Related Subjects of Biochemistry 25: 1-38.
3. Chou KC, Kuo CK, Li TT (1975) The quantitative relations between diffusion-controlled reaction rate and characteristic parameters in enzyme-substrate reaction system: 2. Charged substrates. Scientia Sinica. 18: 366-380.
4. Li TT, Chou KC (1976) The quantitative relations between diffusion-controlled reaction rate and characteristic parameters in enzyme-substrate reaction system: 1. Neutral substrates. Scientia Sinica 19(1): 117-136.
5. Li TT, Chou KC(1977) Studies on the combination rates of liquid phase fast reaction system: Steady state process and transient phase process. Scientia Sinica 20: 197-221.
6. Zhou GZ (1979) Influence of van der Walls' force upon diffusion-controlled reaction rate. Scientia Sinica 17: 845-858.
7. Chou KC, Li TT, Forsen S (1980) The critical spherical shell in enzymatic fast reaction systems. Biophysical Chemistry 12: 265-269.
8. Li TT, Chou KC, Forsen S (1980) The flow of substrate molecules in fast enzyme-catalyzed reaction systems. Chemica Scripta. 16: 192-196.
9. Chou KC, Li TT, Zhou GQ (1981) A semi-analytical expression for the concentration distribution of substrate molecules in fast, enzyme-catalyzed reaction systems. Biochim Biophys Acta 657: 304-308.
10. Zhou GQ, Zhong WZ (1982) Diffusion-controlled reactions of enzymes. A comparison between Chou's model and Alberty-Hammes-Eigen's model. Eur J Biochem 128(2-3): 383-387.
11. Chou KC, Forsen S (1980) Diffusion-controlled effects in reversible enzymatic fast reaction system: Critical spherical shell and proximity rate constants. Biophysical Chemistry 12(3-4): 255-263.
12. Chou KC, Forsen S (1980) Graphical rules for enzyme-catalyzed rate laws. Biochem J 187(3): 829-835.
13. Chou KC, Forsen S, Zhou GQ (1980) Three schematic rules for deriving apparent rate constants. Chemica Scripta 16: 109-113.
14. Chou KC, Carter RE, Forsen S (1981) A new graphical method for deriving rate equations for complicated mechanisms. Chemica Scripta 18: 82-86.
15. Chou KC, Chen NY, Forsen S (1981) The biological functions of low-frequency phonons: 2. Cooperative effects. Chemica Scripta 18: 126-132.
16. Chou KC, Forsen S (1981) Graphical rules of steady-state reaction systems. Can J Chem 59: 737-755.