About 20 years ago a very important paper on prediction of
tight turns and their types in proteins  was published. According
to the definition given in that paper, a tight turn in protein structure
is a site where  a polypeptide chain reverses its overall direction,
i.e., leads the chain to fold back on itself by nearly 180°, and  the
amino acid residues directly involved in forming the turn are no
more than six. In the same paper, various types of tight turns and
how to predict them have been systematically reviewed. Ever since
then, this paper has played very important role for building protein
three dimensional (3D) models for drug development [2-14].
Chou KC (2004) Insights from modelling three-dimensional structures of the human potassium and sodium channels. Journal of Proteome Research 3(4): 856-861.
Chou KC (2004) Insights from modelling the tertiary structure of BACE2. Journal of Proteome Research 3: 1069-1072.
Chou KC (2004) Insights from modelling the 3D structure of the extracellular domain of alpha7 nicotinic acetylcholine receptor. Biochemical and Biophysical Research Communication 319(2): 433-438.
Chou KC (2005) Modeling the tertiary structure of human cathepsin-E. Biochem Biophys Res Commun 331(1): 56-60.
Wei DQ, Du QS, Sun H, Chou KC (2006) Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its binding interactions with ligands. Biochem Biophys Res Comm 344:1048-1055.
Wang JF, Wei DQ, Li L, Zheng SY, Li YX, et al. (2007) 3D structure modeling of cytochrome P450 2C19 and its implication for personalized drug design. Biochem Biophys Res Commun 355(2): 513-519.
Wang JF, Wei DQ, Lin Y, Wang YH, Du HL, et al. (2007) Insights from modeling the 3D structure of NAD(P)H-dependent D-xylose reductase of Pichia stipitis and its binding interactions with NAD and NADP. Biochem Biophys Res Comm 359(2): 323-329.
Wang SQ, Du QS, Chou KC (2007) Study of drug resistance of chicken influenza A virus (H5N1) from homology-modeled 3D structures of neuraminidases. Biochem Biophys Res Comm 354(3): 634-640.
Shen HB, Yi DL, Yao LX, Yang J, Chou KC (2008) Knowledge-based computational intelligence development for predicting protein secondary structures from sequences. Expert Rev Proteomics 5(5): 653-662.
Du QS, Wang SQ, Huang RB, Chou KC (2010) Computational 3D structures of drug-targeting proteins in the 2009-H1N1 influenza A virus. Chem Phys Lett 485: 191-195.