Richard M Fleming*, Matthew R Fleming, Tapan K Chaudhuri, Andrew McKusick and William C Dooley

DOI : 10.32474/OAJOM.2019.03.000154

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Monday 4 February 2019 was yet another World Cancer Day. We celebrated our efforts to find and eradicate cancer without admitting to ourselves that cancer isn’t a single disease, but rather a group of diseases all caused by our bodies responding to the toxic environment we are exposing ourselves to, just as our planet is responding to the toxic wastes we are dumping into it. The question is WHY do our bodies run amok. The answer lies in the same answer to why Global Warming exists...... ReadMore

Richard M Fleming

DOI : 10.32474/OAJOM.2019.03.000153

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In 1927, Werner Heisenberg [1], published his “Uncertainty principle” which in brief states that it is impos-sible to simultaneously know both the position and momentum of an electron or any other particle with any degree of accuracy or “certainty.” To define the location of an electron required interaction with it. This inter-action would result in movement of the electron and as a result, would move the electron...... ReadMore

Surya Prakash Gautam

DOI : 10.32474/OAJOM.2019.03.000152

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Carbon Nano materials the king of nonmaterial’s have fascinating nanofamily including buckyballs or buckminsterfullerenes [1], multiwalled carbon nanotubes [2], the single-walled carbon naotubes(SWCNTs) [3], Carbon Nanohorns(CNHs), Carbon nanocones, Carbon nanofibers (CNFs), carbon nanothread, Buckypaper, carbon dots, nanodimons, nanoonions, nanorods, nanoribbons. Also called as powerful particles, CNTs (carbon nanotubes) has thus bloomed over the past decade...... ReadMore

Dr. Gurmeet Singh Sarla*

DOI : 10.32474/OAJOM.2019.03.000151

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Adequate calcium intake is essential for the maintenance of bone health and the preservation of bone mineral density. The lay person believes that calcium is always good for health. Successful marketing and various clinical practice guidelines have made prescribing calcium supplements a billion dollar market in recent years. The aim of this study was to scan the literature and find out whether calcium supplements should be prescribed to all patients with fractures so as to improve their bone healing or should it be restricted to elderly post- menopausal females who have osteoporotic bones. The inference drawn was that dietary calcium is easier to absorb and may have beneficial effects as compared to calcium supplements and it should be limited to the total daily intake to 1000–1200 mg optimally from dietary sources. Ca..... ReadMore

Lara Abdelmunim I Abdelrahman*, Mohamed E Gar Elanabi and Nahla Gafer

DOI : 10.32474/OAJOM.2019.02.000148

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The study examined the association between Palliative radiotherapy and the improvement of the symptoms associated with metastatic breast cancer. These include metastatic in the spinal cord and associated pain, brain metes and associated symptoms, bone metes, Metastic in the lung and finally spread in organs such as liver and others. The study also dealt with the connection between it and the improvement of the standard of life of the patient and toxic and other important factors and was achieved through a set of international standards questionnaire by which the calibration of the result. The value of radiotherapy for palliation is well known to oncologists but not necessarily to other physicians. Using terms such as symptom improvement ratio (SIR) than traditional response rates might be more appropriate..... ReadMore

Lara Abdelmunim I Abdelrahman*, Mohamed E Gar Elanabi and Nahla gafer

DOI : 10.32474/OAJOM.2019.02.000147

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Pain is one of the most common, unattended and unsolved problem for the cancer patients. Radiotherapy is successful, time efficient, well tolerated. The goal of palliative radiotherapy symptoms relief at the site of primary tumour or from metastic lesion. The study examined the association between Palliative radiotherapy and the improvement of the symptoms associated with metastatic breast cancer. These include metastatic in the spinal cord, bone and associated pain, also dealt with the connection between it and the improvement of the standard of life of the patient and toxic and other important factors and was achieved through a set of international standards questionnaire by which the calibration of the result. This study was conducted in the Center of tumours treatment in Sudan, represented in Khartoum oncology Hospi..... ReadMore

Victoria Aginova* and Natalia Dmitrieva

DOI : 10.32474/OAJOM.2019.02.000146

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The emergence and spread of carbapenem-resistant (CarR) bacteria are a global problem for treatment of patients all over the world. This type of antimicrobial resistant is particularly danger by cancer patients. Regular monitoring of carbapenem-resistant microorganisms and the determination of the mechanism of their spread will help keep CarR bacteria from spreading This article contains the results of monitoring of carbapenem-resistant strains of microorganisms in the oncological clinic...... ReadMore

Tayyaba saher* and Muhammad Imran Qadir

DOI : 10.32474/OAJOM.2019.02.000145

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The present study was objected to check the awareness about SARS among scholars of university. The pupil of Bahauddin Zakariya university Multan acted as the subjects for this research. Total of 109 subjects showed consent to be the part of this study. Severe acute respiratory syndrome (SARS) is considered a deadly animal virus which, perhaps originated from bats and then it was spread to other animals. According to a report, the humans were affected by SARS very firstly in 2002 in Guangdong, china...... ReadMore

Rüdiger Hardeland

DOI : 10.32474/OAJOM.2018.02.000144

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The release of exosomes and ectosomes carrying noncoding RNAs is addressed in the context of cancer, with focus on microRNAs and long noncoding RNAs as well as differences in RNA cargos produced by tumor and nontumor cells. The differential appearance of ncRNAs can be used for diagnostic and prognostic purposes. Beyond these possibilities, the spreading of pathological and beneficial messages deserves particular attention and will gain future importance. Especially the use of exosomes released by cells that overexpress ncRNAs with antitumor properties appears to be a promising strategy...... ReadMore

Misra Jata Shankar

DOI : 10.32474/OAJOM.2018.02.000143

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Carcinoma cervix is a major health problem faced by Indian women and though its incidence has declined in urban population in recent years but in the rural India where 70% of the people dwell, cervical cancer still remains on top [1]. It is mainly due to illiteracy and ignorance about the factors contributing to the development of cervical cancer...... ReadMore

VK Khanna*

DOI : 10.32474/OAJOM.2018.02.000142

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Increasing the population and off them living styles effect on the surrounding environment leads to changes in climate with time. In the long run, the climatic change could affect agriculture in several ways such as quantity and quality of crops in terms of productivity, growth rates, photosynthesis and transpiration rates, moisture availability etc. Among the agricultural crops maize is also one of the most important food crops. Predictions suggest that worldwide climate change will reduce maize production this will coincide with a substantial increase in demand for maize due to rising populations. However, selection for climate change adaptation cultivar is difficult due to complex genotype by environment interactions. The broader use of traits from alien species and the m..... ReadMore

VK Khanna*

DOI : 10.32474/OAJOM.2018.02.000141

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The impact of climate change on agriculture will be one of the major deciding factors influencing the future food security of mankind on earth. Agriculture is not only sensitive to climate change but, at the same time, is one of the major drivers for climate change. Understanding the weather changes over a period of time and adjusting the management practices towards achieving better harvest is a challenge to the growth of agricultural sector as a whole. The most imminent climatic changes in recent times is the increase in the atmospheric temperatures due to increased levels of greenhouse gases such as carbon dioxide (CO 2 ), methane (CH 4 ), ozone (O 3 ), nitrous oxide (N 2 O) and chloro fluoro carbons (CFCs)...... ReadMore

Bakulesh Khamar*

DOI : 10.32474/OAJOM.2018.02.000140

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Checkpoint inhibitors have demonstrated efficacy in squamous NSCLC with tolerable toxicity profile. They are used as a monotherapy, in combination with chemotherapy or following chemo-radiotherapy as a first line, second line or consolidation therapy. As a first line, Pembrolizumab improves outcome (PFS) as a monotherapy in patients with PD-L1 expression of ≥ 50% (HR; 0.35). When used with chemotherapy, it improves PFS (HR; 0.56) irrespective of PD-L1 expression level. Nivolumab also improves PFS (HR; 0.62), when used as a second line for those progressing with chemotherapy. Durvalumab improves PFS (HR; 0.68) when used following chemo-radio therapy as a consolidation therapy...... ReadMore

Lale Olcay*

DOI : 10.32474/OAJOM.2018.02.000139

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We evaluated our thrombosis cases for iron deficiency (ID) or iron deficiency anemia (IDA) retrospectively and reviewed the literature. We established that iron parameters were studied in 17 of 64 patients with thrombosis and 2 of 17 patients had IDA. Case 1 (age 16, female) had occlusions in sigmoid and transverse sinuses and right jugular vein and case 2 (age 15, male) had infarct in right cerebellar hemisphere. While case 1 additionally had mastoiditis, high Factor (F) VIII and PAI 4G/5G polymorphism, case 2 who underwent a recent aortic graft insertion operation for aortic aneurysm had high serum lipids, lipoprotein a, homocysteine, FVIII, d-dimer. Of 54 thrombosis cases with ID/IDA in the literature, cerebral thrombosis made up of 70.4% of all the cases, venous cerebral occlusions comprising 100% and 66% of venous thrombo..... ReadMore

Obeagu Emmanuel Ifeanyi*

DOI : 10.32474/OAJOM.2018.02.000138

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Leukaemia is a blood disorder caused by uncontrolled production and release of abnormal blasts cells in the bone marrow and in the circulation. Treatment of leukaemia has been a great challenge and many patients die. The initial methods of treatments were chemotherapy and radiation which target the leukaemic cells. There is a concern on the management of leukaemia patients. This paper was written to enlighten the public on the need to utilize umbilical cord blood in the management of leukaemia patients...... ReadMore

Nathaniel A Parker*

DOI : 10.32474/OAJOM.2018.02.000137

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Uterine leiomyomas are the most common gynecological tumor in women of reproductive age. These tumors are typically benign entities, but uncommonly transition toward tissues of malignant potential. Rare growth patterns of uterine leiomyomata have been observed which include benign metastasizing leiomyoma (BML), disseminated peritoneal leiomyomatosis (DPL), intravenous leiomyomatosis (IVL), retroperitoneal leiomyomatosis (RPL) and parasitic leiomyoma (PL). Metastasis of uterine fibroids most commonly appear several years after the diagnosis and removal of uterine leiomyomata by hysterectomy. For two women who sought treatment for BML and IVL in our clinic, we retrospectively outlined and evaluated their specific genetic, pathological, and clinical features with the intention to elucidate possible t..... ReadMore

Wilson Ib Onuigbo*

DOI : 10.32474/OAJOM.2018.02.000136

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A 13-year retrospective study of reprint requestors was undertaken with special reference to those from research libraries. It was found that 2.8 percent of the total 2,053 requests were from such librarians. They preponderated in USA, East Germany, Australia, France and Britain. The reason for their requests included Reprint Library acquisitions and exhibition purposes. The librarians tended to ask for reprints from foreign rather than local Journals. All indications are that the reprint has played an important role in scientific communication. In particular, the librarians, who work in research libraries, deserve special scrutiny...... ReadMore

Makki H Fayadh*

DOI : 10.32474/OAJOM.2018.02.000135

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Colorectal cancer is the fourth (4 th ) common cancer in both sexes, worldwide and is the third most common cancer in men and the second in women. b) In 2012, 1.36 million cases of colorectal cancer occurred and there were 693,881 deaths c) The incidence is increasing under age 50 and it is the second killer cancer in UAE in 2017 [1]. d) According to health authority of Abu Dhabi( HAAD) in a report published in 2012 colon cancer is the 2 nd common cancer and 4 th common cause of cancer deaths in men and 3 rd most common cancer and 2 nd common cause of cancer deaths in women..... ReadMore

Paul TE Cusack*

DOI : 10.32474/OAJOM.2018.02.000134

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I was asked to submit a minireview to this journal on oncology. I’ll share an antidotal observation that may prove useful to cancer researchers. I studied hyper-ferritism and Ferric Chloride to see its possible link to schizophrenia. Those results are well published [1,2]. However, I noticed from that research a trend that 12 patients who should have had high hydrogen peroxide (H2O2) also universally had had some form of cancer in their medical history. I wonder if H2O2 is not a carcinogen? Could the H2O2 break down that cell walls leading to cell mutation? I’m not an expert on cancer, nor do I intend to be, but perhaps this clue may lead to further research into to the causes of cancer...... ReadMore

Lawrence M Agius*

DOI : 10.32474/OAJOM.2018.02.000133

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Dimensional representation of events actively executing the cell cycle dynamics of progression in carcinogenesis allow for aparadoxical emergence of highly permissive elements in the establishment of the mitotic spindle and the separation of chromatids. In such terms, ongoing processes of dissolution of the nuclear membrane betray an essential permissiveness in cell cycling that is paramount constitutional characterization of a process as “passenger” event in defining malignant transformation. In real terms, incremental progression of the cell cycle is specific hallmark for the events that constitutionally permit the system machinery in mitosis to conclusively establish potential re-setting of events as non-re-replication of the cell cycle in the re-emerging G1 phase of mitotic activity..... ReadMore