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Research Article
Mohsen Navari, Maryam Etebari, Navid Pourzardosht, Arash Arashkia, Davide Gibellini, Pier Paolo Piccaluga* View abstract
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Human papillomavirus (HPV) is a risk factor for several human tumors, including head and neck cancers (HNC). The presence of the virus could impact the expression of the host microRNAs, leading to global change in the gene expression profile of the host cells. We studied such effects using in silico methods. We analyzed the gene expression profile of 38 HPV-positive and 180 HPVnegative HNC cases that were publicly available...... ReadMore -
Research Article
Shai Waldrip, Jingyao Xu, Yunlong Qin, Danita Eatman, E Shyam P Reddy and Veena N Rao* View abstract
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Triple-negative breast cancer (TNBC), which accounts for 15-20% of all invasive breast cancer cases, is a particularly aggressive form of breast cancer that disproportionately affects young African-American (AA) women. Approximately 75-80% of breast cancer patients who have BRCA1 mutations will develop TNBC in their lifetime...... ReadMore
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Review Article
Hind Sahli*, Sanae Amalik, Asaad El bakkari, Hounayda Jerguigue, Rachida Latib, Youssef Omor View abstract
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A man, aged 50 years, admitted to our training for management of an undifferentiated carcinoma of nasopharyngeal type known by the acronym UCNT (Undifferentiated Carcinoma of Nasopharyngeal Type)...... ReadMore
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Review Article
Pier Paolo Piccaluga*, Chiara Cascianelli, Clara Beruzzi, Stefano Ascani, Giulio Fraternali-Orcion, Stefano Lazzi, Lorenzo Leoncini and Giuseppe Visani View abstract
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Malignant lymphomas are the commonest hematological cancers, accounting for about 50% of them. Despite being diagnosed worldwide, differences have been reported in terms of absolute incidence in different geographical areas, being more frequently seen in Europe and Northern America rather than Asia and Africa. Even more evident is the different distribution of lymphoma types, based on the presence of different causative agents (e.g., HTLV1), postulated genetic backgrounds (eg. EBV-associated T-cell neoplasms), or unknown reasons. In this study, we aimed to assess, for the first time, the specific incidence of lymphoma types in Italy...... ReadMore
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Review Article
Abdulghani A Naeem, Saud A Abdulsamad, Asmaa Al Bayati, Jiachen Zhang, Mohammed I Malki, Hongwen Ma and Youqiang Ke* View abstract
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When it comes to studying biological processes, cell lines are typically utilized in lieu of original cell samples. Like in the studies for other cancer types, researchers in prostate cancer can be constrained in their ability to discover new treatments because of a lack of cell lines to investigate pre-clinical status. There are various forms of prostate cancer cell lines that are reviewed in this work. A cautionary note is in need since cell lines may not always correctly mimic the original cells. Cancerous cells are immortal and using cell lines produced from cancer cells as a model to better understand cancer and to develop novel therapies are common in research. Apart from the prostate cancer cells, we also reviewed two cell lines PNT2 and RWPE-1 which were established from non-neoplastic male prostatic epithelial c..... ReadMore
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Review Article
BM Petrikovsky* View abstract
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Precision medicine is a novel trend for treatment and prevention that emphasizes individual variability in genes, family history, and lifestyle for each person. This approach allows doctors to accurately predict which treatment and prevention strategies will work for an individual. It is in contrast to the one-size-fits-all approach used now where treatment and prevention are designed for the average person, not taking into account the differences between individuals. Although the term “precision medicine” is new, the concept has been known for years. For example, a person requiring blood transfusion is not given blood from a random donor; instead, the donor’s blood type is matched to the recipient. Precision medicine is different from boutique medicine. The latter is designed for wealthy consumers who are not interested to wait in ..... ReadMore
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Review Article
Xi Jin, Bandar A Alenezi, Gang He, Hongwen Ma, Qiang Wei, and Youqiang Ke* View abstract
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Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) is a transcription factor that is ligand dependent and is a member of the nuclear hormone receptor superfamily. PPARγ is expressed in two isoforms: PPARγ1 and PPARγ2, the latter contains thirty extra amino acids (Figure 1). Both synthetic and endogenous ligands can band to and activate PPARγ [1]. When activated, PPARγ is translocated into the nucleus and forms a heterodimer with the retinoid X receptor (RXR), where it serves as a transcriptional regulator of genes via DNA binding [2]. It is well established that PPARγ plays a critical role in adipocyte differentiation, the inflammatory response, and peripheral glucose consumption. PPARγ agonists are frequently utilised to treat type II diabetes [1]. Diabetes type II is the most prevalent endocrine-metabolic condition worldwi..... ReadMore
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Review Article
Xi Jin, Asmaa Al-Bayati, Gang He, Jiacheng Zhang, Qiang Wei and Youqiang Ke* View abstract
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Fatty acid-binding proteins (FABPs) are a group of molecules playing important roles in lipid transportation. FABPs are expressed in different configurations in numerous tissues and have diverse functions [1]. Transportation of fatty acids into cells is achieved either through membrane diffusion or via help of receptors like G-protein. FABPs act as a chaperone regulating all functions of cell lipid transportation and storage. Inside cells, FABPs send lipid to endoplasmic reticulum for signalling, to mitochondria for oxidative process, and to nucleus for transcription activity. All members of FABPs can bind long chain fatty acids, however; they differ in their selectivity, affinity and binding mechanism [2]. It is clear that the roles of FABPs are various and include the transportation of fatty acids to cells, participating in PPAR signal ..... ReadMore
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Open Access Journal of Oncology and Medicine (OAJOM) aims to provide effective cancer therapies through the discovery and development of novel therapeutics where we pine to select a pioneering researches and practitioners with their valuable ideas and articles based on medicine (diagnosis and treatment of disease and the maintenance of health) and oncology (treatments of tumors) of common, acute, long term, late effects and its recently developed treatments and welcomes research across all tumor types and their treatments in medical oncology, surgical oncology and radiation oncology. And also on two major divisions of medicine academic medicine and clinical medicine. Some of the branches of medicine are environmental medicine, family medicine, forensic medicine, internal medicine, and physical medicine. It maintains a precise, conscientious fair peer review system. Besides, quality control is engrossed in each step of the publication is in high quality Our editorial team is committed to improving the researcher experience by providing excellent editorial service, fast publication, and high visibility for all papers.
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