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Current Trends on Biotechnology & Microbiology

Mini Review(ISSN: 2641-6875)

An Overview on the Roles of Bacterial Small RNAs in Regulatory Networks

Volume 1 - Issue 5

Melih AŞAN1, Mustafa AKÇELİK2 and Nefise AKÇELİK1*

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    • 1Biotechnology Institute, Ankara University, Ankara, Turkey
    • 2Biology Department, Faculty of Science, Ankara University, Ankara, Turkey

    *Corresponding author: Nefise AKÇELİK, Biotechnology Institute, Ankara University, Ankara, Turkey

Received:March 13, 2020;   Published: June 18, 2020

DOI: 10.32474/CTBM.2020.01.000123

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Bacterial small RNAs (sRNAs) are important molecules that regulate the expression of certain genes, depending on the different growth conditions of the cell and they are widely used by bacteria. sRNAs help the bacteria survive by being involved in many cellular processes such as nutrient deficiency, mobility, pH adaptation and oxidative stress. Current studies have succeeded in elucidating how sRNAs modulate the expression of different transcription factors. Thus, the integration of sRNA activity into comprehensive regulatory networks has begun to take place. Regulatory networks include regulatory circuits that have characteristic functions. In this review, the roles of some characterized sRNAs in regulatory networks and their effects on transcription factors are discussed. Furthermore, we describe specific regulatory circuits containing base pairing sRNAs and their importance in global regulation.

Keywords: Small RNA; regulatory network; transcriptional regulator

Abstract| Introduction| Regulatory Networks Involving sRNAs| Conclusion| References|