The Effect of Adding Magnesium to Bupivacaine as an
Adjuvant in Continuous Pectoralis Nerve II (PECs) Block in
Simple Mastectomy
Volume 2 - Issue 5
Eman M Kamal Abo Seif, Walid Y Kamel and Amr M Hilal Abdou*
- Department of Anesthesia, Ain Shams University, Egypt
Received: February 10, 2020; Published: February 20, 2020
Corresponding author: Amr M Hilal Abdou, Department of anesthesia and intensive care. Ain Shams University, Egypt
DOI: 10.32474/GJAPM.2020.02.000148
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Abstract
Background and Aim: Breast surgeries are associated with post-operative pain and restricted shoulder mobility, so the
aim of this study is to assess the analgesic efficiency and safety of Continuous Pectorals II (PECs) block by adding magnesium to
bupivacaine as an adjuvant versus bupivacaine as a sole agent in cases of simple mastectomy.
Patients and Methods: This randomized double blinded study designed to compare the analgesics efficacy and safety of
continuous PECs II using bupivacaine versus continuous PEC II using bupivacaine plus magnesium in patients undergoing simple
mastectomy and postoperative period. We enrolled 40 adult females ASA I-II patients’ candidates for simple mastectomy without
axillary clearance. All patients were randomly distributed into two groups. Control group: prior to surgical incision patients had
ultrasound guided PEC II continuous block with 10ml plain bupivacaine 0.25% plus followed by infusion of 8ml normal saline
per hour. Magnesium group: patients were given 10ml plain bupivacaine 0.25% plus 0.5 gm (5ml) magnesium sulfate followed by
infusion of 0.25% plain bupivacaine 7ml/h. plus 10 mg (1 ml) magnesium sulfate infusion per hr.
Results: For assessment of the postoperative pain scores by the VAS; our results showed significant reduction in the magnesium
group (P<0.001) in comparison with control group. Intraoperative vital data in the form of heart rate (HR) and mean arterial blood
pressure (MAP) showed highly significant decrease of the heart rate in the magnesium group (P≤0.001) after 30 minutes from the
block till 2 hours after the block compared to the control group, in addition to significant decrease in MAP (P = 0.036) after the block
by 30 minutes. Postoperative vitals showed significant decrease of HR (P=0.016) in magnesium group 4 hours after surgery till the
following day, highly significant decrease in RR (P <0.001).
Conclusion: This clinical study proven that mixing of magnesium sulphate to bupivacaine during PECs II block provided a solid
safe prolonged motor and sensory block, besides the reduction of postoperative additional rescue pain medications and pain scores.
Abstract|
Introduction|
Methodology|
Anesthetic Management|
PECs II Block Technique|
Collected Data|
Statistical Analysis|
Results|
Discussion|
Conclusion|
Conflict of interest|
Author’s Contribution|
References|