Phenylephrine Effectiveness in Handling Hypotensive Issues During Spinal Anesthesia Conductance for Cesarean Section Deliveries

Volume 2 - Issue 1

Mohamed Sayed Fahim*

Received: August 01, 2019;   Published: August 08, 2019

DOI: 10.32474/GJAPM.2019.02.000126

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Abstract

Background: Hypotension is frequent clinical challenge during spinal mode of anesthetic induction for cesarean delivery. Requiring an effective and prompt management mode since it has unfavorable clinical outcomes such as hemodynamic cardiovascular instability issues besides reduced uteroplacental perfusion.

Aim: Investigating the impact and effectiveness of different prophylactic dosages of Phenylephrine on hypotensive issues during spinal anesthesia for cesarean section deliveries.

Methodology: A prospective, randomized, clinical research study involved 184 cases That are classified as American Society of Anesthesiologists physical status I and II with term singleton pregnancies scheduled for elective cesarean section under spinal anesthesia randomized to receive 0.9% saline 2mL (Control Group) or phenylephrine1.0ug/kg (PHE1 research Group), 1.5ug/kg (PHE1.5 research Group), or 2.0ug/kg (PHE2 research Group) immediately after induction of spinal anesthesia.

Results: The adverse effects of prophylactic bolus of Phenylephrine among the research groups control, Phenylephrine 1,1.5,2 in which there was statistically significant difference as regards hypotension, rescue Phenylephrine, lowest SBP, highest SBP, early highest SBP, mean SBP, occurrence of hypertension (p values=<0.001, <0.001,0.002, <0.001, <0.001, <0.001, <0.001 consecutively) there was no statistical significant difference as regards nausea and bradycardia (p values=0.929, 0.823 consecutively).

Conclusions: The research findings obtained denote and imply that a prophylactic Phenylephrine 1.5ug/kg bolus followed by additional boluses when necessary could be an alternative management protocol to decrease the frequency of hypotensive issues occurrence during spinal anesthetic mode for cesarean deliveries.

Keywords: Cesarean section; Phenylephrine; Spinal hypotension

Abstract| Introduction| Aim of the work| Methodology| Primary Research Outcome| Statistical Analysis| Discussion| Conclusion and Recommendation for Future Research| References|