Effect of Combination Superdisintegrants on the Drug Delivery of Tolvaptan. Hcl Volume 3 - Issue 5

Raghavendra Kumar Gunda*¹, Prasada Rao Manchineni² and Rajini Sudireddy³

• ¹Department of Pharmaceutics, M.A.M College of Pharmacy, Andhra Pradesh, India
• ²Department of Pharmaceutical Analysis, M.A.M College of Pharmacy, Andhra Pradesh, India
• ³Department of Pharmacy Practise, M.A.M College of Pharmacy, Andhra Pradesh, India

Received: February 16, 2021;   Published: March 03, 2021

Corresponding author: Raghavendra Kumar Gunda, Department of Pharmaceutics, M.A.M college of Pharmacy, India

DOI: 10.32474/DDIPIJ.2021.03.000176

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Abstract

The main objective of the current work is to study the effect of super disintegrants in combination for the drug release of Tolvaptan. HCl by developing Fast Disintegrating Tablets (FDT). Tolvaptan. HCl, a newer aquaretic sorvaptan. It mainly used for the effective management of Hyponatremia associated with Syndrome of Inappropriate Anti Diuretic Hormone (SIDAH). Mouth dissolving formulations of Tolvaptan. HCl were prepared using different quantities of Kollidon & Primellose employed as Superdisintegrants by Direct Compression technique. Amount of super disintegrants need to get desired drug release was labeled as factors. Disintegration time, wetting time, times taken for dissolution were labeled as responses. Nine trials were formulated as per 32 factorial design and characterized for quality control parameters. Data obtained from the results reveals that formulations show satisfactory compendial limits. Data obtained from the dissolution study fitted well to kinetic modeling. THF1 composed of 50 milligrams of Kollidon & 50 milligrams of Primellose considered as best compared with all formulations. It shows similarity with HYPONAT-O-30 (f2= 71.32, f1= 4.84). THF1 follow higuchi kinetics with nonfickian diffusion of first order model (n= 0.846).

Keywords: Tolvaptan HCl; Super disintegrants; Kollidon; Primellose; Non-Fickian Diffusion

Abstract| Introduction| Materials and Methods| Characterization 0f Tolvaptan. Hcl Fast Dissolving Tablets| Results and Discussion| Conclusion| Acknowledgement| References|