A Rare Case of Aggravated Hypercalcemia of Malignancy After Surgery Volume 6 - Issue 4

Eun Jang Yoon¹, Seungho Jung¹, Sungwon Na¹, Jiwoo Suh¹, Tae-Hwan Yoon² and Jeongmin Kim¹*

• ¹Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University, South Korea
• ²Department of Orthopaedic Surgery, Arthroscopy and Joint Research Institute, Severance Hospital, Yonsei University, South Korea

Received:July 16, 2021   Published:July 30, 2021

Corresponding author: Jeongmin Kim, Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University, South Korea

DOI: 10.32474/SCSOAJ.2021.06.000242

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Abstract

Paraneoplastic syndromes are caused by ectopic hormone production in malignant tumors. Hypercalcemia of malignancy is the main manifestation of paraneoplastic syndromes and can lead to acute kidney injury, life-threatening arrhythmia, and cardiac arrest. Here, we present a 70-year-old Asian female with a probable diagnosis of advanced lung cancer with hypercalcemia of malignancy. She underwent surgery to treat a pathologic fracture of the humerus. In this case, hypercalcemia of malignancy was unexpectedly aggravated after surgery, and hypercalcemic complications led to a poor outcome for the patient.

Abbreviations: HCM: Hypercalcemia of Malignancy; BPM: Beats Per Minute; ICU: Intensive Care Unit; AKI: Acute Kidney Injury; POD: Postoperative Day; PVC: Premature Ventricular Complexes; CRRT: A Continuous Renal Replacement Therapy; HHM: Humoral Hypercalcemia of Malignancy; IL: Interleukin; ECG: Electrocardiography; PTH: Parathyroid Hormone; PTHrP: Parathyroid Hormonerelated Peptide

Abstract| Introduction| Case Report| Discussion| Conclusion| References|