Pruritus and erythroderma could be a presenting sign of numerous internal malignancies. These symptoms can occur in the early stages of internal malignancies or precede them by months. On the other hand, these symptoms can also be caused by various other common conditions; therefore, they are not specific for paraneoplastic diseases. We report the case of systemic anaplastic large cell lymphoma accompanied by erythroderma.
It was a 74 year old patient with a history of anaplastic lymphoma in remission for one year, who has had erythroderma for
4 months for which he consulted with several doctors and was put on dermocorticoids with good progress and relapse. Dermatological examination: presence of erythroderma in regression in the body with persistence of an erythematous background and presence of scaling in the face (Figure 1). On examination of the ganglionic areas: presence of multiple centimetric lymphadenopathy at fixed axillary and inguinal level, without inflammatory signs. The patient was referred to the internal medicine department where a relapse of his lymphoma was confirmed. The patient started chemotherapy 1 month ago.
Figure 1: Presence of erythroderma in regression in the body with persistence of an erythematous background and presence of scaling in the face.
Paraneoplastic cutaneous disorders (PCDs) or dermadromes are skin conditions that have an association with internal malignancies but are not themselves malignant. Several cases of dermatomyositis, bullous dermatosis, erythroderma, prurigo, lichen planus and porokeratosis are considered PCDs. The most important point is that no malignant cells infiltrate into the skin lesions of PCDs [1-3]. The phenomenon of a paraneoplastic dermatosis was first described by Hebra [4] in 1868 when he suggested that pigmentation of the skin could indicate underlying malignancy [5]. Erythroderma as a PCD has been linked to malignancies such as mycosis fungoides or its leukaemic variant, Sezary syndrome. Additional reported cases exist that describe erythroderma associated with cancers of the liver, lung, colon, stomach, pancreas, thyroid, prostate and
cervix [2]. The mechanism behind paraneoplastic dermatoses is
still largely unknown. It is thought that the skin changes are due
to either an immunologic reaction to the tumor antigen directly or
indirectly as a result of inflammatory cytokines produced by the
tumor. Paraneoplastic erythroderma is more agressive and resistant
to standart treatment modalities. Weakness, and significant weight
loss are frequently seen as additional findings. It can be associated
with fine scaling and hyperpigmentation (melanoerythroderma).
Erythroderma manifests as widespread erythema accompanied by
a variable degree of scaling, typically involving over 90% of the body
surface area [6]. It is most commonly caused by atopic dermatitis,
psoriasis as well as hypersensitivity reactions to drugs. Cases of
erythroderma associated with malignancy tend to be presented
as Sezary syndrome which is a type of cutaneous T cell lymphoma.
Less commonly, paraneoplastic erythroderma is associated with
acute myeloid leukaemia and solid tumours [7,8]. Paraneoplastic
erythroderma associated with systemic lymphoma is exceptionally
rare.
Paraneoplastic dermatoses can be the initial presentations of
systemic lymphoma. Knowledge about this association may help with timely diagnosis. In a patient with unexplained dermatosis, an
investigation for systemic lymphoma is warranted.
Rook A, Burns T (2010) Rook’s Textbook of Dermatology (8th), Wiley Blackwell Chichester West Sussex UK HobokenNJ USA.
Motoori M, Tsujinaka T, Kobayashi K, Fujitani K, Kikkawa N (2001) Synchronous rectal and esophageal cancer associated with prurigo chronica multiformis: report of a caseSurg Today 31: 1087-1090.