Polymorphic Estimation of Clopidogrel hydrogen sulfate Form-II in Clopidogrel hydrogen sulfate Form-I by X-ray diffractometer Volume 7 - Issue 2

Amit Gosar, Shivaji Jadhav, Mithun Gharat*, Mahesh Patil and Dyandev Kadu

• Amit Gosar, Shivaji Jadhav, Mithun Gharat*, Mahesh Patil and Dyandev Kadu

Received: December 07, 2021   Published: December 15, 2021

Corresponding author: Mithun Gharat, Department of Chemistry, University of Mumbai, India

DOI: 10.32474/RRHOAJ.2021.07.000257

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Clopidogrel hydrogen sulfate Form-I possibly may convert into Clopidogrel hydrogen sulfate Form-II and determination of Clopidogrel hydrogen sulfate form-II content with accurate quantitation is difficult and Clopidogrel hydrogen sulfate Form-II determination method is not reported in literature. Hence, novel specific and accurate method has been developed for the Polymorph estimation of Clopidogrel hydrogen sulfate Form-II by X-ray crystallography. The method has been developed and validated as per International conference on Harmonization guidelines (Q2R1) and found out specific Linear, Precise and accurate in validation. The described method is accurate and validated and successfully applied for the Polymorph estimation of Clopidogrel hydrogen sulfate Form-II in Clopidogrel hydrogen sulfate Form-I.

Keywords: Breast cancer; Softmax function; Adam algorithm; Biological activity

Abstract| Introduction| Specificity| Linearity, Lod and Loq Determination| Precision| Precision at Limit of Quantitation (Loq)| Accuracy at Different Levels| Results and Conclusion| References|