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ISSN: 2637-6679

Research and Reviews on Healthcare: Open Access Journal

Mini Review(ISSN: 2637-6679)

Organofluorine Compounds in Fluorine-18 Positron Emission Tomography Imaging

Volume 5 - Issue 3

Ivor Smajlagic, Rozhin Rowshanpour, Lea Milkin and Travis Dudding*

  • Author Information Open or Close
    • Department of Chemistry, Brock University, Canada

    *Corresponding author: Travis Dudding, Department of Chemistry, Brock University, St. Catharines, ON L2S 3A1, Canada, Email:

Received: June 15, 2020;   Published: June 24, 2020

DOI: 10.32474/RRHOAJ.2020.05.000213

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The application of organofluorine compounds is widespread with many current uses in the life sciences and medical field. As modern methods for the introduction of fluorine into molecules continue to develop, so is the growing use of fluorine and its radioisotope, fluorine-18, in the medical field. This mini review summarizes some of the major advancements pertaining to 18F radiotracers for positron emission tomography (PET) imaging and its application as a tool to aid in the diagnosis of Alzheimer’s disease and cancer. Further offered is a brief overview of synthetic methods for preparing organofluorine compounds and rise of organotrifluoroborates in 18F PET imaging.

Keywords: PET imaging; Fluorine; Radionuclide; Alzheimer’s disease; Cancer; Organotrifluoroborates

Abstract| Introduction| Cancer and 18F PET Imaging| Conclusion| Acknowledgements| Funding| References|