The application of organofluorine compounds is widespread with many current uses in the life sciences and medical field.
As modern methods for the introduction of fluorine into molecules continue to develop, so is the growing use of fluorine and its
radioisotope, fluorine-18, in the medical field. This mini review summarizes some of the major advancements pertaining to 18F
radiotracers for positron emission tomography (PET) imaging and its application as a tool to aid in the diagnosis of Alzheimer’s
disease and cancer. Further offered is a brief overview of synthetic methods for preparing organofluorine compounds and rise of
organotrifluoroborates in 18F PET imaging.
Keywords: PET imaging; Fluorine; Radionuclide; Alzheimer’s disease; Cancer; Organotrifluoroborates