Familial Mediterranean Fever: What associations to
screen for? (A Review)
Volume 5 - Issue 2
Salem Bouomrani1* and Ines Masmoudi2
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- 1Department of Internal medicine, Military Hospital of Gabes, Tunisia
- 2Sfax Faculty of Medicine, University of Sfax, Tunisia
*Corresponding author:
Salem Bouomrani, Department of Internal medicine, Military Hospital of Gabes, Tunisia
Received: April 27, 2020; Published: May 12, 2020
DOI: 10.32474/RRHOAJ.2020.05.000206
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Abstract
Familial Mediterranean Fever (FMF) is the most common and best known of hereditary recurrent fever or periodic fever
syndromes. It was described in 1945 and genetically characterized in 1992; caused by a point mutation in the “MEFV” gene located
on the short arm of chromosome 16. It is particularly frequent among Sephardic Jews, Armenians, Turks and Middle Eastern Arabs
where the prevalence can reach 1/2000 to 1/1000. Recent publications objectified its frequent association with other diseases
and/or syndromes, particularly those of autoimmune, genetic, and auto-inflammatory origin. The objective of this review is to
familiarize healthcare professionals with the main associations to look for in patients followed for FMF. The early detection of these
associations makes it possible to improve the management and the prognosis of patients with FMF.
Keywords: Familial Mediterranean Fever; Periodic fever; Diseases; Pyrine; Association; Chronic inflammation; MEFV gene
Abstract|
Introduction|
FMF and Its Most Frequent Associations|
Conclusion|
Conflicts of Interest|
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