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ISSN: 2637-6679

Research and Reviews on Healthcare: Open Access Journal

Research Article(ISSN: 2637-6679)

Evaluation of Free Radicals and Some Other Biochemical Parameters in Leukemia and Β-Thalassemia in Erbil City

Volume 4 - Issue 3

Pshtiwan Abdulla Yousif, Parween Abdulsamad Ismail* and Avein Fhaithwlla

  • Author Information Open or Close
    • Department of Chemistry, Education College, University of Salahaddin, Iraq

    *Corresponding author: Parween Abdulsamad Ismail, Department of Chemistry/Education College, University of Salahaddin, Erbil, Iraq

Received: November 11, 2019;   Published: December 02, 2019

DOI: 10.32474/RRHOAJ.2019.04.000189

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Background: Free radicals have been shown to be involved in the etiology of degenerative diseases, and medical conditions such as heart disease, cancer and ageing. Various biochemical markers are indicators of pathological state in both thalassimia and leukemia. Increased oxidative stress and decreased antioxidant factors play a key role in the pathogensis of both diseases. High ROS production has been associated with significant decrease in antioxidant defense mechanisms leading to protein, lipid and DNA damage.

Aim: To conduct comparative analysis of MDA and as a marker of oxidative stress in patients with β-thalassimia and leukemia. Materials and methods: This research work was conducted on a total number of 95 subjects in which 20 were control participants and 75 patients (35males and 40 females) mean age (59. 2 ± 3.5 years) The levels of serum lipids, MDA, total Sialic acid, catalase and total protein, were measured in all participants.

Results: In both groups of patients β-thalassimia and leukemia Serum MDA and total Sialic acid levels were significantly higher when compared to the controls (p<0.001). The results showed significant decrease (p<0.001) in Catalase activity of thalassemic and leukemic patients in comparing with healthy control group. No significant differences were observed in the comparison of total protein levels between patients’ group and healthy control group.

Conclusion: Oxidative stress is involved in pathogensis of of thalassemia and leukemia, as evident from elevated malondialdehyde levels and decreased catalase activity. Elevated levels of sialic acid andtotal proteins suggest the role of glycoproteins in carcinogenesis proceses.

Keywords: Free radicals; Leukemia; β-Thalassemia

Abstract| Introduction| Materials and Methods| Results| Discussion| Conclusion| References|


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