Eclampsia is a life-threatening condition with highest mortality and morbidity characterized by uncontrolled hypertension unconsciousness
fits albumin urea in the setting the of Pre-Eclampsia.
Study: An extensive elaborative study carried out from 2005 to 2009, to study the therapeutic and prophylactic role of
Magnesium Sulphate and Diazepam in Eclampsia.
Study Period: Four years 2005 to 2009
Objective: To study MgSo4 Vs Diazepam reducing MMR, NMR in Eclampsia
Study Design: This was a comparative study. Total 500 patients of fulminent pre-Eclampsia/Eclampsia were studied included
booked/un-booked patients attending Lady Willingdon Hospital were admitted evaluated assessed and put on MgSo4 Vs Diazepam
divided in two groups. The results were compared which showed of MgSo4 as superior in efficacy of compared to Diazepam in
improving overall mortality morbidity in Eclampsia.
Material and Methods: Total 500 patients of Eclampsia admitted and studied in Unit-2 Lady Willingdon Teaching Hospital of
King Edward Medical University Lahore managed in ICU according to a special design proforma, protocol and were given MgSo4 and
Diazepam for control of fits, Hydralazine, Labetalol and Isoket infusions for lowering-blood pressure (MgSO4) A+B. (Diazepam) with
multi-disciplinary involvement divided in two groups compared and followed up.
Results: In Group-A there were 20 mothers and in Group-B 40 mothers died. It was observed that maternal mortality was
significantly higher in Group-B women as compared to that of Group-A. i.e. (p-value=0.005) In Group-A there were 20 mothers and
in Group-B 40 mothers died. It was observed that maternal mortality was significantly higher in Group-B women as compared to
that of Group-A. i.e. (p-value=0.005).
Conclusion: The comparative study and of role of MgSO4 Vs Diazepam in reducing Mortality, morbidity in maternities, neonates,
efficacy showed the superiorness of Magnesium Sulphate as compared to Diazepam without any doubt.