Importance of Chronic Endometritis (CE) in RIF-An Update on Diagnosis and Treatment

Volume 2 - Issue 5

Kulvinder Kochar Kaur¹*, Gautam Allahbadia² and Mandeep Singh³

Received:November 05, 2019;   Published: November 18, 2019

DOI: 10.32474/OAJRSD.2019.02.000146

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Chronic Endometritis(CE) refers to continuing inflammation within the endometrial lining that is secondary to bacterial organisms. Reproductive failure has been associated with CE for labelling a diagnosis of plasma cells(PC) visualization within the endometrial stroma is considered the criteria. The prevalence in infertile women especially those with recurrent implantation failure(RIF) varies markedly. This discrepancy is there because of no diagnostic criteria that has been agreed upon. Here we have carried out a systematic review to decide what should be the best diagnostic criteria, either on the basis of EB or hysteroscopy as per the international committee on the hysteroscopy group or the newer data that suggests checking PC density(PCD) i n endometrial biopsy (EB) samples based on presence of PC even in fertile women and using 95% of PCD in fertile women and utilization of next generation sequencing of 16S ribosomal RNA subunit. Further utilization of antibiotics orally has been the conventionally used methods of treating CE. But 2 groups have demonstrated good cure rate of CE following direct instillation of antibiotics/antibiotics with dexamethasone in the uterine cavity that resulted in spontaneous conceptions which suggests intrauterine administration of antibiotics once a diagnosis of CE has been made remains the best answer for RIF patients as seen with spontaneous conceptions though more randomized trials are needed for the same.

Keywords: CE; PCD; RIF; uterine cavity antibiotics/antibiotics with dexamethasone; hysteroscopy; 16S ribosomal RNA subunit

Abstract| Introduction| Method| Results and Discussion| Newer Methods of Diagnosis| Methods of Treatment| Conclusion| References|