Apoptosis in Human Cumulus Cells and Intracytoplasmic
Sperm Injection Outcomes
Volume 2 - Issue 5
Eman Anwar Hassan1, Mohamed SM Nasr2 and Behery MA3*
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- 1Embryology unit, the International Islamic Institute for Population Studies and Research,Al-Azhar University, Egypt
- 2Department of Histology and Cell biology, Faculty of Medicine, Al-Azhar University, Egypt.
- 3ART unit, the International Islamic Institute for Population Studies and Research, Al-Azhar University, Egypt
*Corresponding author:
Behery MA, ART unit, the International Islamic Institute for Population Studies and Research, Al-Azhar
University, Heliopolis, Cairo, Egypt
Received:March 13, 2020; Published: April 07, 2020
DOI: 10.32474/OAJRSD.2020.02.000148
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Abstract
Apoptosis as a genetically controlled form of cell death is closely associated with most of the reproductive processes. It has been
reported that the incidence of apoptosis in granulosa or Cumulus cells may be used as a predictive factor in the outcome of assisted
reproduction cycles. In this study it was revealed that the incidence of apoptosis in cumulus increased with increased female age
and that influences fertilization rate, number of MII oocytes in addition to the number of Grade A embryos.
Keywords: Oocyte-Cumulus, Age; Fertilization; ICSI; Outcomet
Abbreviations: CC: Cumulus cells; ICSI: intracytoplasmic sperm injection; cAMP: cyclic adenosine monophosphate; OCC: Oocytecumulus
complexes; SOD: superoxide dismutase
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