Apoptosis as a genetically controlled form of cell death is closely associated with most of the reproductive processes. It has been
reported that the incidence of apoptosis in granulosa or Cumulus cells may be used as a predictive factor in the outcome of assisted
reproduction cycles. In this study it was revealed that the incidence of apoptosis in cumulus increased with increased female age
and that influences fertilization rate, number of MII oocytes in addition to the number of Grade A embryos.