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ISSN: 2641-1644

Open Access Journal of Reproductive System and Sexual Disorders

Research Article(ISSN: 2641-1644)

Apoptosis in Human Cumulus Cells and Intracytoplasmic Sperm Injection Outcomes

Volume 2 - Issue 5

Eman Anwar Hassan1, Mohamed SM Nasr2 and Behery MA3*

  • Author Information Open or Close
    • 1Embryology unit, the International Islamic Institute for Population Studies and Research,Al-Azhar University, Egypt
    • 2Department of Histology and Cell biology, Faculty of Medicine, Al-Azhar University, Egypt.
    • 3ART unit, the International Islamic Institute for Population Studies and Research, Al-Azhar University, Egypt

    *Corresponding author: Behery MA, ART unit, the International Islamic Institute for Population Studies and Research, Al-Azhar University, Heliopolis, Cairo, Egypt

Received:March 13, 2020;   Published: April 07, 2020

DOI: 10.32474/OAJRSD.2020.02.000148

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Abstract

Apoptosis as a genetically controlled form of cell death is closely associated with most of the reproductive processes. It has been reported that the incidence of apoptosis in granulosa or Cumulus cells may be used as a predictive factor in the outcome of assisted reproduction cycles. In this study it was revealed that the incidence of apoptosis in cumulus increased with increased female age and that influences fertilization rate, number of MII oocytes in addition to the number of Grade A embryos.

Keywords: Oocyte-Cumulus, Age; Fertilization; ICSI; Outcomet

Abbreviations: CC: Cumulus cells; ICSI: intracytoplasmic sperm injection; cAMP: cyclic adenosine monophosphate; OCC: Oocytecumulus complexes; SOD: superoxide dismutase

Abstract| Introduction| Materials and Methods| Discussion| Conclusion| Conflict of interests| Acknowledgment| References|

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