email   Email Us: phone   Call Us: +1 (914) 407-6109   57 West 57th Street, 3rd floor, New York - NY 10019, USA

Lupine Publishers Group

Lupine Publishers

  Submit Manuscript

ISSN: 2637-4722

Progressing Aspects in Pediatrics and Neonatology

Case Report(ISSN: 2637-4724)

Neuroprotective Effects Of D-Penicillamine In The Neonatal Period: Case Reports

Volume 2 - Issue 3

Lajos Lakatos*

  • Author Information Open or Close
    • Department of Pediatrics, University of Debrecen, Hungary

    *Corresponding author: Lajos Lakatos, Department of Pediatrics, Faculty of Medicine, University of Debrecen, Hungary

Received: October 24, 2019   Published: October 30, 2019

DOI: 10.32474/PAPN.2019.02.000140

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF


D-penicillamine (D-PA) was first used as a potential benefit for neonatal hyperbilirubinemia (NHBI) caused by hemolytic diseases of the newborn infant or immaturity of UDP-glucuronyltransferase enzyme. In this time there was a remarkedly low incidence of retinopathy of prematurity (ROP) in the infants treated with D-PA. Later, our studies were replicated in other institutes in Hungary, Poland, the USA, India and Mexico. It is important to note that there was no intolerance or short- or long-term toxicity of the medication, in spite of the fact that D-PA was used 10-20 times higher doses in the newborn period, than those in adult age. To our concept, the bilirubin-induced neurologic dysfunction (BIND), ROP and Autism Spectrum Disorders (ASD) are neurodegenerative and neurodevelopmental diseases (NDs) of immature brain caused by accumulation of free metals, unconjugated bilirubin (UCB), and UCB-Cu complex (as prooxidant), respectively, in the basal ganglia (BG) and other relevant parts of the central nervous system (CNS). The main cause is the hemolysis of neonatal red blood cells producing a great amount of heavy metals (mainly iron and copper) which are inducing reactive oxygen species (ROS). These elements can be find in the bloodstream, and pass through the immature blood-brain-barrier (BBB). In addition, ROS contribute to increased BBB permeability creating a dangerous vitious circle in the neonatal brain.

Keywords: D-Penicillamine In the Neonatal Period; Orphan Drug; Copper Hypothesis of BIND; ROP and ASD; Follow-Up Studies

Abstract| Introduction| Case Reports| Conclusion| References|