Immune and Inflammatory Responses in Neonatal Seizures

Volume 2 - Issue 4

Behzad Saberi*

Received: December 04, 2019   Published: December 18, 2019

DOI: 10.32474/PAPN.2019.02.000141

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Abstract

There would be an important role for inflammation in the neonatal seizure disorders. Also, in status epilepticus and the brain injury consequences of that, inflammatory processes play an important role. IL-6, IL-1b, TNF-a and immune cells increased expression, has been found in seizure disorders [1-5]. The production of cytokines would be induced by epileptic seizures. Such cytokines production will influence seizures and their pathogenesis. After the occurrence of seizures, releasing the HMGB1 protein and IL-1b from macroglia and astrocytes will happen.

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