Objective: To present the different clinical manifestations and diagnostic strategies of isolated sphenoid non-invasive fungal
sinusitis (SNIFS) in order to prevent delayed diagnosis and providing early management.
Method: This study is a retrospective clinical study, conducted between January 2008 to November 2019. It was done in the
ENT department of two institutes: King Fahad specialist Hospital and Qatif Central Hospital, Saudi Arabia. Only patients with sole
involvement of non-invasive fungal sinusitis in the sphenoid sinus were included.
Conclusion: The incidence of SNIFS is rare. However, it’s clinically important because untreated SNIFS can cause significant
complications. The clinical features of SNIFS are ambiguous and nonspecific which make its diagnosis more difficult. Post-nasal
discharge and headache refractory to the medical management is the most common symptom of SNIFS. CT scan is still the
cornerstone of radiological diagnosis of SNIFS. Endoscopic sinus surgery is the standard care of management.