The Role of P2y6 Receptor in Disease Occurrence and Progression Volume 5 - Issue 3

Yu Ren¹, Zhong Zhu² and Hua Luo²*

• ¹Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Zhejiang, China
• ²Department of orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Zhejiang, China

Received:May 27, 2021   Published:June 9, 2021

Corresponding author:Hua Luo, Department of Orthopaedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou 317000, Zhejiang, China, No. 150, Ximen Street, Linhai, Taizhou, Zhejiang 317000, China

DOI: 10.32474/OSMOAJ.2021.05.000212

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Abstract

The P2Y6 receptor is a sub-type of P2Y receptors belonging to the G protein-coupled receptors family. The receptor is widely distributed and has recently gained attention because of its roles in various physiological processes. Moreover, the receptor has been implicated in the occurrence and development of many diseases. The activation of P2Y6 receptor leads to different biochemical pathways, depending on the disease context and the pathological environment. With the physiological functions, pharmacological features, and clinical value of P2Y6R has been revealed, targeted to P2Y6Ras new drugs make a great significance for a variety of disease prevention and control. This article reviews reorganized the distribution, properties, and diseases associated with P2Y6 receptor. We present evidence that P2Y6 receptor may have a detrimental or beneficial role in different pathological mechanisms and physiological processes, providing a theoretical basis for studies related to P2Y6 receptor.

Keywords:Purine Receptor; P2y6; Distribution; Properties; Role in Disease

Abstract| Introduction| Properties and Signal Transduction of P2Y6R| The Role of P2Y6R in Cardiovascular System| P2Y6R Involved in the Occurrence and Development of Neurological Diseases| P2Y6R and Insulin Secretion| P2Y6R and Insulin Secretion| Conclusion| Declarations| Introduction| Consent for publication| Availability of Data and Materials| Competing Interests| Authors’ Contributions| Funding| Acknowledgements| References|