Ingrid K Stake1, Naomasa Fukase2, Sudheer Ravuri3, C Thomas Haytmanek4, Thomas O Clanton5 and Johnny Huard6*
Received: July 29, 2020; Published: September 16, 2020
Corresponding author:Johnny Huard, Steadman Philippon Research Institute, 181 W. Meadow Drive, Suite 1000, Vail, Colorado 81657, Colorado, USA
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Orthobiologics are receiving increasing interest in an effort to improve cartilage healing after acute and chronic injuries. In osteochondral lesions (OCLs) of the ankle joint, orthobiologics can be used alone or as an adjunct to surgical treatment to optimize the repair tissue. Several treatment options are currently available, including bone and cartilage grafts, cell and/or matrix transplants, and biological adjuncts. However, little consensus exists on how to best use these orthobiologics for optimal repair. The aim of this review was to summarize the latest literature for the treatment of OCLs of the ankle joint, focusing on the most common biological adjuncts; hyaluronic acid (HA), platelet-rich plasma (PRP), and bone marrow aspirate concentrate (BMAC). Additionally, new therapeutic strategies to biologically regulate the cartilage environment to further improve cartilage healing are also discussed.
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Gastroenterology and HepatologyUniversity of Alabama, UK
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Analytical ChemistryWentworth Institute of Technology, USA
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