Frontiers in Orthobiologics for the Treatment of Osteochondral Lesions of the Ankle Joint Volume 4 - Issue 3

Ingrid K Stake¹, Naomasa Fukase², Sudheer Ravuri³, C Thomas Haytmanek⁴, Thomas O Clanton⁵ and Johnny Huard⁶*

• ¹Department of Orthopaedic Surgery, Ostfold Hospital Trust, Norway and Steadman Philippon Research Institute, Colorado, USA
• ²Steadman Philippon Research Institute, Colorado and Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Japan
• ³Steadman Philippon Research Institute, Colorado, USA
• ⁴The Steadman Clinic, Colorado, USA
• ⁵The Steadman Clinic and Steadman Philippon Research Institute, Colorado, USA
• ⁶Steadman Philippon Research Institute, Colorado, USA

Received: July 29, 2020;   Published: September 16, 2020

Corresponding author:Johnny Huard, Steadman Philippon Research Institute, 181 W. Meadow Drive, Suite 1000, Vail, Colorado 81657, Colorado, USA

DOI: 10.32474/OSMOAJ.2020.04.000188

 

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Abstract

Orthobiologics are receiving increasing interest in an effort to improve cartilage healing after acute and chronic injuries. In osteochondral lesions (OCLs) of the ankle joint, orthobiologics can be used alone or as an adjunct to surgical treatment to optimize the repair tissue. Several treatment options are currently available, including bone and cartilage grafts, cell and/or matrix transplants, and biological adjuncts. However, little consensus exists on how to best use these orthobiologics for optimal repair. The aim of this review was to summarize the latest literature for the treatment of OCLs of the ankle joint, focusing on the most common biological adjuncts; hyaluronic acid (HA), platelet-rich plasma (PRP), and bone marrow aspirate concentrate (BMAC). Additionally, new therapeutic strategies to biologically regulate the cartilage environment to further improve cartilage healing are also discussed.

Abstract| Introduction| Microfracture| Bone and Cartilage Grafts| Cell and/or Matrix Transplants| Biological Adjuncts| Conclusion| References|