ISSN: 2638-6003
Julian Doll1*, Franziska Bürkle1, Arndt Neide1, Stefanos Tsitlakidis1, Thomas Bruckner2, Gerhard Schmidmaier1 and Christian Fischer1
Received: July 29, 2020; Published: August 10, 2020
Corresponding author: Dr. med Julian Doll, Center for Orthopedics, Trauma Surgery and Spinal Cord InjuryUltrasound CenterHTRG – Heidelberg Trauma Research GroupHeidelberg University Hospital, Germany
DOI: 10.32474/OSMOAJ.2020.04.000186
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Background: The market for dietary supplements in the sports sector has been growing rapidly for several years, though there is still lacking evidence regarding their claimed benefits. One group is that of nitric oxide increasing supplements, so-called “NOboosters”, which are claimed to improve the supply of oxygen and nutrients to the muscle by enhancing vasodilation.The aim of this study was to investigate three of these supplements in healthy male athletes for their muscle perfusion-enhancing potential using contrast-enhanced ultrasound (CEUS).
Methods: This placebo-controlled, double-blind, randomized cross-over trial will be carried out at the Center for Orthopedics, Trauma Surgery and Spinal Cord Injury of the University Hospital Heidelberg. Three commercial NO enhancing products including 300 mg of the specific green tea extract VASO6™ and a combination of 8 g L-citrulline malate and 3 g L-arginine hydrochloride will be examined for their potential to increase muscular perfusion in 30 male athletes between 18 and 40 years and will be compared with a placebo. On each of the three appointments CEUS of the dominant biceps muscle will be performed at rest and after standardized resistance training. Every athlete receives each of the three supplements once after a wash-out period of at least one week. Perfusion will be quantified via VueBox® quantification software. The results of CEUS perfusion measurements will be compared intra- and interindividually and correlated with clinical parameters.
Discussion: The results of this study may help to establish CEUS as a suitable imaging modality for the evaluation of potentially vasodilatory drugs in the field of sports. Other supplements could also be evaluated in this way to verify the content of their advertising claims.
Trial registration: German Clinical Trials Register (DRKS), ID: DRKS00016972, registered on 25.03.2019.
Keywords: Contrast-enhanced ultrasound; biceps muscle; muscle perfusion; L-citrulline malate; L-arginine; green tea extract; VASO6™
Abstract| Background| Methods and Design| Instructions| Quantification| Statistical Analyses| Discussion| Strengths and limitations| Declarations| Consent for publication| Availability of Data and Materials| Competing Interests| Funding| Authors’ contributions| References|
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