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ISSN: 2637-6628

Online Journal of Neurology and Brain Disorders

Case Report(ISSN: 2637-6628)

Cervical Tarlov Cyst Mimicking Spinal Hydatid Disease: Case Report Volume 3 - Issue 2

Marouane Hammoud*, F Lakhdar, M Benzagmout, K Chakour and MF Chaoui

  • Department of Neurosurgery, University Sidi Mohammed Ben Abdellah, Morocco

Received: October 21, 2019;   Published: November 05, 2019

Corresponding author: Marouane Hammoud, Department of Neurosurgery, Hassan II University Hospital of Fez, University Sidi Mohammed Ben Abdellah, Fez, Morocco

DOI: 10.32474/OJNBD.2019.03.000161

Abstract PDF

Abstract

Background: Perineurial (Tarlov) cysts are usually incidental findings during magnetic resonance imaging of the lumbosacral spine. The Cervical localization have been reported to be a rare occurrence. We report such a case where a high cervical perineural cyst was masquerading as a spinal hydatid disease.

Case Presentation: We report a case of symptomatic cervical Tarlov cyst in a 9 years old girl operated on twice for pulmonary and hepatic hydatid cyst. Spinal magnetic resonance imaging (MRI) showed an extradural intraspinal lesion with fluid-equivalent signal extending from C5 to T2. Based on the history, the diagnosis of spinal hydatid disease was suggested. Surgical excision of the cyst resulted in significant improvement in patient symptoms, and histological examination revealed the diagnosis of a Tarlov cyst.

Conclusion: Cervical perineural (Tarlov) cyst can be symptomatic by causing nerve root compression and can be mistaken as a spinal hydatid disease on imaging. Surgical treatment can be curative.

Keywords: Tarlov Cyst; Hydatid Cyst; Diagnosis; Management MRI; Cervical Spine

Abbreviations: TC: Tarlov Cyst; CSF: Cerebrospinal Fluid; MRI: Magnetic Resonance Imaging

Introduction

Tarlov Cyst (TC) is defined as a cystic dilatation between the perineurium and endoneurium of spinal nerve roots, located at level of the spinal ganglion and filled with Cerebrospinal Fluid (CSF) but without communication with the perineurial subarachnoid space [1]. It is most often found in the sacral spine with a prevalence of 4.6% in the general population with about 13% of those being symptomatic [1,2]. The Cervical localization have been reported to be a rare occurrence [3], to our knowledge there are only five published cases of symptomatic cervical Tarlov cyst [4]. MRI of the spine is the gold standard imaging modality for the diagnostics. This is a case report of a symptomatic cervical TC that was masquerading as a spinal hydatid disease. To our knowledge, only five other cases of symptomatic cervical TC have been published [3,4].

Case Presentation

A 9-year-old girl, with medical history of surgery for pulmonary and hepatic hydatid cysts at age of 8, treated with anthelmintic with good outcome. As far as her past medical history is concerned, there were a history of cervical plexus trauma at the age of 6 with monoparesis sequelae of the left arm. She presented with a 4-week history of gradually developing left hemiparesis. On clinical exam, all deep tendon reflexes were normal. Proximal muscle strength of the left leg and the ipsilateral upper extremity was 3/5. Electromyography (EMG) showed abolition of motor and sensory responses of nerves SPE and SPI on the left upper limb. MRI of the cervical spine showed intraspinal cystic lesion of extra-Dural location lateralized to the left, extending from C5 to T2 causing a stenosis of the adjacent foramina, without contrast enhancement of the cyst wall (Figure 1). Based on the imaging and the history of patient, the diagnosis of a spinal hydatid disease was suspected. Neurosurgical indication was agreed, and the patient underwent a C4-T2 laminotomy (Figure 2), intraoperatively, cystic lesions strongly adhered to the dural mater with an appearance that was evoking congenital cysts. At this point, we opened the capsule and a clear CSF-like liquid came out from the cyst, we conducted a careful excision with Dural plasty. The histological examination showed fibrous tissue and the presence of neural elements, which is typical for perineural cysts. Postoperatively, the patient experienced significant improvement in her symptoms, represented by improved left lower-limb strength. A postoperative MRI of the cervical spine was performed after 6 months showed no recurrence of the cyst (Figure 3).

Figure 1: T2-weighted axial MRI showing an intraductal cystic lesion lateralized to the left and protruding in the adjacent neuro foramina. Squeezing the cervical spinal cord

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Figure 2: C4 to T2 laminotomy, and the cystic lesion that has a translucid wall (arrows).

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Figure 3: Sagittal (a) and axial (b) post opérative spinal MRI after 6 months showing the disappearance of the cyst and the pressure lifted on the cervical cord.

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Discussion

Tarlov cysts, or perineural cysts, firstly described by I.M. Tarlov in 1938 as an incidental finding during his autopsy studies of the filum terminale [5]. They are pathological fluid collections located between the peri- and endoneurium, i.e. meningeal dilatations of the nerve sheat at the dorsal root ganglion. They are filled with liquor; therefore the signal is isointense to liquor on all MRI sequences [6]. They are often multiple and are mainly located in the sacral region, cervical location is rare. In a systematic study Burdan et al. reported about a prevalence of 1.2% of cervical perineural cysts [7]. They are symptomatic in 13% of cases according to Langdown et al. [1]. The exact physiopathology of perineural cysts remains unclear, and several hypotheses have been proposed. Tarlov suggested that hemosiderin deposition caused blockage of the venous drainage of the perineurium and epineurium after local trauma can lead to the development of these cysts [4]. Other authors discuss a developmental or congenital origin [8]. The onset of symptoms can be sudden or gradual, and are exacerbated by coughing, standing, and change of position [8], those symptoms depend on their location, and range from backache, perineal pain or sciatica to overt cauda equina syndrome [5]. TC is usually diagnosed using diagnostic imaging. X-ray can show bone erosion in the anterior or posterior part of the vertebral foramen [9]. The CT scan may show CSF isodense cystic mass at the foramen [10]. Myelography was used for the positive diagnosis of TC, it allowed the identification of the communication of the cyst with the subarachnoid space, and late filling phenomenon allowing the differential diagnosis with other cystic lesions of meningeal origin, which are not TC [11]. Spinal MRI is currently the method of choice in diagnosis of perineural cysts, it shows a cystic lesion, located near the dorsal root ganglion with a hypointense signal through T1 weighted imaging, a hyperintense signal through T2 weighted imaging, without godalinium enhancement. The differential diagnosis is mainly with other spinal meningeal cysts. The classification of Nabor et al. makes it possible to differentiate three types: Type I: extradural cysts without nerve fiber, type Ia: arachnoid cyst extradural. Type Ib: meningocele sacred. Type II: extradural cysts containing nerve cells (TC). Type III: arachnoid cyst intradural [12]. It is also important to distinguish with neurogenic tumors such as schwannoma, those solid tumors enhance after gadolinium injection, Joshi et al. reported about a central perineural cyst masquerading a tumor, the cyst was located intra spinally and caused compression of the cervical myelon [13] Till date, published treatment options for apparently symptomatic TC include medication, percutaneous procedures, and surgery. However, these methods are associated with various outcomes and complications. Mitra et al described a conservative approach for a symptomatic cervical TC using oral steroids after initial ineffective course of NSAIDs. A six-day-course of oral steroids was given, leading to relief of symptoms, as far as, the upper extremity motor strength was concerned, but with a slight increase in the patient’s sense of pain [14]. Kim et al. performed a more invasive transforaminal epidural steroid injection for a case of symptomatic perineural cyst in the cervical spine [15]. Epidural steroid injection was primarily employed to reduce neural inflammation causing radicular symptoms, but the follow-up MRI revealed a shrunken cyst in this case, which was an unexpected result of the intervention. Jungwon Lee et al. Performed ultrasound-guided cervical elective nerve root block using local anesthetics and steroids without fenestration of the cyst in a case of symptomatic cervical TC which was resistant to medication [16]. Therefore, ultrasound-guided cervical selective nerve root block is a safe and effective procedural option for the treatment of symptomatic cervical perineural cysts. The microsurgical approach usually involves a small laminectomy with cyst fenestration, cyst imbrication, cyst neck ligation, cyst resection, and combinations of the above [8,17,18]. Combining the evidence from 31 case series Laura E. Dowsett et al. found that after surgical treatment, the symptoms attributed to TC either completely or partially relieved in 83% of the cases. Complete resolution was experienced in 32% of cases, 50% had partial resolution, 16% had no improvement or worsening of symptoms and 0.4% had worsening of symptoms after surgery [19]. However, the optimal management of symptomatic TC is still a matter of ongoing debate because of the variety of outcomes and complications for each method. Percutaneous aspiration of a perineural cyst can cause headaches owing to intracranial hypotension [2]. Fibrin glue placement of perineural cysts is associated with several complications including aseptic meningitis and CSF leakage [20, 21]. Surgical excision of these cysts can also result in complications involving neural damage, pseudomeningocele, and intracranial hypotension [19].

Conclusion

In conclusion, symptomatic cervical perineural cysts are extremely rare. In the present case, because of the rarity of the lesion, we did not suspect a TC at first, however, it should be kept in mind in front of any intraspinal cystic lesion, and surgical excision may be an effective option for symptomatic cases.

References

  1. Langdown AJ, Grundy JR, Birch NC (2005) The clinical relevance of Tarlov cysts. J Spinal Disord Tech 18(1): 29-33.
  2. Paulsen RD, Call GA, Murtagh FR (1994) Prevalence and percutaneous drainage of cysts of the sacral nerve root sheath (Tarlov cysts). AJNR Am J Neuroradiol 15(2): 293-297.
  3. Gossner J (2018) High prevalence of cervical perineural cysts on cervical spine MRI. Int J Anat Var 11(1): 18-19.
  4. Zibis A, Fyllos A, Arvanitis D (2015) Symptomatic cervical perineural (Tarlov) cyst: A case report. Hippokratia 19(1):76-77.
  5. Tarlov IM (1970) Spinal perineurial and meningeal cysts. J Neurol Neurosurg Psychiatry 33(6): 833-843.
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  7. Burdan F, Mocarska A, Janczarek M, Klepacz R, Łosicki M, et al. (2013) Incidence of spinal perineurial (Tarlov) cysts among East-European patients. Plos One 8(8): 71514.
  8. Lucantoni C, Than KD, Wang AC, Valdivia Valdivia JM, Maher CO, et al. (2011) Tarlov cysts: A controversial lesion of the sacral spine. Neurosurg Focus 31(6): 14.
  9. Taveras JM, Wood EH (1976) Diagnostic neuroradiology (2nd); Williams and Wilkins: Baltimore, 1139-1145.
  10. Tabas JH, Deeb ZL (1986) Diagnosis of sacral perineural cysts by computed tomography. J Comput Tomogr 10(3):255-259
  11. Landers J, Seex Br (2002) Sacral perineural cysts: Imaging and treatment options. J Neurosurg 16(2): 182-185.
  12. Nabors MW, Pait TG, Byrd EB, Karim NO, Davis DO, et al. (1988) Updated assessment and current classification of spinal meningeal cysts. J Neurosurg 68(3): 366-377.
  13. Poshi VP, Zanwar A, Karande A, Agrawal A (2014) Cervical perineural cyst masquerading as a cervical spinal tumor. Asian Spine J 8(2): 202-205.
  14. Mitra R, Kirpalani D, Wedemeyer M (2008) Conservative management of perineural cysts. Spine (Phila Pa 1976) 33(16): 565-568.
  15. Kim K, Chun SW, Chung SG (2012) A case of symptomatic cervical perineural (Tarlov) cyst: Clinical manifestation and management. Skeletal Radiol 41(1): 97-101.
  16. Jungwon Lee, Kilhyun Kim, Saeyoung Kim (2018) Treatment of a symptomatic cervical perineural cyst with ultrasound-guided cervical selective nerve root block. Medicine 97(37): 12412.
  17. Elsawaf A, Awad TE, Fesal SS (2016) Surgical excision of symptomatic sacral perineurial Tarlov cyst: Case series and review of the literature. Eur Spine J 25(11): 1-8.
  18. Seo DH, Yoon KW, Lee SK, Kim YJ (2014) Microsurgical excision of symptomatic sacral perineurial cyst with sacral recapping laminectomy: A case report in technical aspects. J Korean Neurosurg Soc 55(2): 110–113.
  19. Laura E Dowsett, Fiona Clement, Stephanie Coward, Diane L Lorenzetti D and on behalf of the University of Calgary HTA Unit (2017) Effectiveness of Surgical Treatment for Tarlov Cysts : A Systematic Review of Published Literature. Clin Spine Surg 31(9): 377-384.
  20. Murphy K, Oaklander AL, Elias G, Kathuria S, Long DM (2016) Treatment of 213 patients with symptomatic Tarlov cysts by CT-guided percutaneous injection of fibrin sealant. Am J Neuroradiol 37(2): 373-379.
  21. Patel M, Louie W, Rachlin J (1997) Percutaneous fibringlue therapy of meningeal cysts of the sacral spine. AJR Am J Roentgenol 168(2): 367-370.
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